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Archives of Gynecology and Obstetrics
Published in: Archives of Gynecology and Obstetrics 4/2011

01-10-2011 | Materno-fetal Medicine

The association between inherited thrombophilias and pregnancy-related hypertension recurrence

Authors: Inanc Mendilcioglu, Turker Bilgen, Yunus Arikan, Ibrahim Keser, Mehmet Simsek, Aysen Timuragaoglu

Published in: Archives of Gynecology and Obstetrics | Issue 4/2011

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Abstract

Purpose

The aim of this study was to determine the association between inherited thrombophilias and pregnancy-related hypertension recurrence.

Methods

In this case–control study, blood samples were obtained from patients who had at least two pregnancies complicated with pregnancy-related hypertension (n = 41) and healthy, normotensive pregnancies delivered without any complication (n = 38). Following the DNA extraction, samples were tested for factor V Leiden, prothrombin G20210A and homozygous methylene tetrahydrofolate reductase (MTHFR) C677T mutations using reverse hybridization method.

Results

Common inherited thrombophilias were present in 26.8% of women with recurrent pregnancy-related hypertension group and 23.7% of control subjects (odds ratio 1.1; 95% confidence interval, 0.6–1.9). No significant difference was observed between two groups in terms of factor V Leiden, prothrombin G20210A and MTHFR C677T mutations.

Conclusion

Our data suggest that factor V Leiden, prothrombin G20210A and MTHFR C677T mutations are not associated with pregnancy-related hypertension recurrence.
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Metadata
Title
The association between inherited thrombophilias and pregnancy-related hypertension recurrence
Authors
Inanc Mendilcioglu
Turker Bilgen
Yunus Arikan
Ibrahim Keser
Mehmet Simsek
Aysen Timuragaoglu
Publication date
01-10-2011
Publisher
Springer-Verlag
Published in
Archives of Gynecology and Obstetrics / Issue 4/2011
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-010-1756-y

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