Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Archives of Gynecology and Obstetrics
Published in: Archives of Gynecology and Obstetrics 5/2011

01-05-2011 | Materno-fetal Medicine

Umbilical cord blood acid–base and gas analysis after early versus delayed cord clamping in neonates at term

Authors: Catalina De Paco, Jesús Florido, Mari Carmen Garrido, Sonia Prados, Luis Navarrete

Published in: Archives of Gynecology and Obstetrics | Issue 5/2011

Login to get access

Abstract

Objective

To compare umbilical cord acid–base status and blood gas analysis between umbilical cords clamped within 10 s and at 2 min of delivery.

Methods

A total of 158 healthy full-term mothers were randomly assigned to an early clamping (<10 s post-delivery, n = 79) or delayed clamping (2 min post-delivery, n = 79) group. After application of inclusion criteria, umbilical vein blood acid–base status and gases were analyzed in 65 early clamped and 51 delayed clamped cords. Fewer cases could be examined in the umbilical artery: 55 cords in the early clamping group and 44 in the delayed one.

Results

Acid–base and gas analysis results did not significantly differ between the groups in the umbilical vein or umbilical artery, with the exception of a higher (p < 0.001) mean umbilical artery pO2 value in the delayed versus early clamping group. No significant differences in umbilical vein or artery pCO2 or HCO3 − values were observed between the early and delayed clamp groups.

Conclusions

A delay of 2 min before umbilical cord clamping does not significantly change acid–base and gas analysis results, with the exception of a higher mean umbilical artery pO2 value in the delayed clamping group.
Literature
1.
Darwin E (1801) Zoonomia, 3rd edn. London, pp 302
2.
McDonnell M, Henderson-Smart DJ (1997) Delayed umbilical cord clamping in preterm infants: a feasibility study. J Paediatr Child Health 33:308–310PubMedCrossRef
3.
Ibrahim HM, Krouskop RW, Lewis DF, Dhanireddy R (2000) Placental transfusion: umbilical cord clamping and preterm infants. J Perinatol 20:351–354PubMedCrossRef
4.
Rabe H, Wacker A, Hülskamp G, Hörnig-Franz I, Schulze-Everding A, Harms E et al (2000) A randomized controlled trial of delayed cord clamping in very low birth weight preterm infants. Eur J Pediatr 159:775–777PubMedCrossRef
5.
Mercer JS, McGrath MM, Hensman A, Silver H, Oh W (2003) Immediate and Delayed Cord Clamping in infants born between 24 and 32 weeks: a pilot randomized controlled trial. J Perinatol 23:466–472PubMedCrossRef
6.
Van Rheenen PF, Gruschke S, Brabin BJ (2006) Delayed umbilical cord clamping for reducing anaemia in low birthweight infants: implications for developing countries. Ann Trop Paediatr 26:157–167PubMedCrossRef
7.
Mercer JS, Vohr BR, McGrath MM, Padbury JF, Wallach M, Williams Oh (2006) Delayed cord clamping in very preterm infants reduces the incidence of Intraventricular Hemorrhage and Late-Onset Sepsis: A Randomized, Controlled Trial. Pediatrics 117:1235–1242PubMedCrossRef
8.
Kugelman A, Borenstein-Levin L, Riskin A, Chistyakov I, Ohel G, Gonen R et al (2007) Immediate versus delayed umbilical cord clamping in premature neonates born <35 weeks: a prospective, randomized, controlled study. Am J Perinatol 24:307–315PubMedCrossRef
9.
Baezinger O, Stolkin F, Keel M, Siebenthal H, Fauchere JC, Das Kundu S et al (2007) The influence of the timing of cord clamping on postnatal cerebral oxygenation in preterm neonates: a randomized, controlled trial. Pediatrics 119:455–459CrossRef
10.
Rabe H, Reynolds G, Diaz-Rosello J (2008) A systematic review and meta-analysis of a brief delay in clamping the umbilical cord of preterm infants. Neonatology 93:138–144PubMedCrossRef
11.
Ultee CA, Van der Deure J, Swart J, Lasham C, Van Baar AL (2008) Delayed cord clamping in preterm infants delivered at 34–36 weeks’ gestation: a randomized controlled trial. Arch Dis Child Fetal Neonatal Ed 93:F20–F23PubMedCrossRef
12.
Strauss RG, Mock DM, Johnson KJ, Cress GA, Burmeister LF, Zimmerman MB et al (2008) A randomized clinical trial comparing immediate versus delayed clamping of the umbilical cord in preterm infants: short-term clinical and laboratory endpoints. Transfusion 48:658–665PubMedCrossRef
13.
Van Rheenen P, De Moore L, Eschbach S, De Grooth H, Brabin B (2007) Delayed cord clamping and haemoglobin levels in infancy: a randomized controlled trial in term babies. Trop Med Int Health 12:603–616PubMedCrossRef
14.
Hutton EK, Hassan ES (2007) Late vs early clamping of the umbilical cord in full-term neonates. Systematic review and meta-analysis of controlled trials. JAMA 297:1241–1252PubMedCrossRef
15.
McDonalds SJ, Middleton P (2008) Effect of timing of umbilical cord clamping of term infants on maternal and neonatal outcomes. Cochrane Database Syst Rev 16:CD004074
16.
Oxford Midwives Research Group (1991) A study of the relationship between the delivery to cord clamping interval and the time of cord separation. Midwifery 7:167–176CrossRef
17.
Nelle M, Zilow EP, Bastert G, Linderkamp O (1995) Effects of Leboyer childbirth on cardiac output, cerebral and gastrointestinal blood flow velocities in full-term neonates. Am J Perinatol 12:212–216PubMedCrossRef
18.
Nelle M, Zillow EP, Kraus M, Bastert G, Linderkamp O (1993) The effect of Leboyer delivery on blood viscosity and other hemorheologic parameters in term neonates. Am J Obstet Gynecol 169:189–193PubMed
19.
Grajeda R, Pérez-Escamilla R, Dewey KG (1997) Delayed clamping of the umbilical cord improves hematologic status of Guatemalan infants at 2 mo of age. Am Clin Nutr 65:425–431
20.
Nelson NM, Enkin MW, Saigal S, Bennett KJ, Milner R, Sackett DL (1980) A randomized clinical trial of the Leboyer approach to childbirth. N Engl J Med 302:655–660PubMedCrossRef
21.
Van Rheenen P, Brabin BJ (2004) Late umbilical cord-clamping as an intervention for reducing iron deficiency anaemia in term infants in developing and industrialised countries: a systematic review. Ann Trop Paediatr 24:3–16PubMedCrossRef
22.
Geethanath RM, Ramji S, Thirupuram S, Rao YN (1997) Effect of timing of cord clamping on the iron status of infants at 3 months. Indian Pediatr 34:103–106PubMed
23.
Yao AC, Moinian M, Lind J (1969) Distribution of blood between infant and placenta after birth. Lancet 2:871–873PubMedCrossRef
24.
Maternal Health and Safe Programme. Care in normal birth: a practical guide (1997) Report of the technical working group. Geneva. Maternal and Newborn Health/Safe Motherhood Unit, Family and Reproductive Health, World Health Organization, WHO/FRH/MSM/96.24
25.
Zaramella P, Freato F, Quaresima V, Secchieri S, Milan A, Grisafi D et al (2008) Early versus late cord clamping: effects on peripheral blood flow and cardiac function in term infants. Early Hum Dev 84:195–200PubMedCrossRef
26.
Usher R, Shephard M, Lind J (1963) The blood volume of the newborn infant and placental transfusion. Acta Paediatr Scand 52:497–512CrossRef
27.
Saigal S, O′Neill A, Surainder Y, Chua LB, Usher R (1972) Placental transfusion and hyperbilirubinemia in the premature. Pediatrics 49:406–419PubMed
28.
ACOG Committee on Obstetric Practice. ACOG Committee Opinion No. 348 (2006) Umbilical cord blood gas and acid–base analysis. Obstet Gynecol 108:1319–1322CrossRef
29.
Armstrong L, Stenson BJ (2007) Use of umbilical cord blood gas analysis in the assessment of the newborn. Arch Dis Childhood Fetal 92:430–434CrossRef
30.
Johnson JWC (1993) Umbilical blood acid–base analysis. Clin Obstet Gynecol 36:1CrossRef
31.
FIGO (1987) Guidelines for the use of fetal monitoring. Int J Gynaecol Obstet 25:159–167
32.
Morley GM (1998) Cord closure: can hasty clamping injure the newborn? OBG Manage 7:29–36
33.
Kunzel W (1982) Cord clamping at birth—considerations for choosing the right time. Z Geburtshilfe Perinatol 186:59–64PubMed
34.
Wiberg N, Källén K, Olofsson P (2008) Delayed umbilical cord clamping at birth has effects on arterial and venous blood gases and lactate concentrations. BJOG 115:697–703PubMedCrossRef
35.
Armstrong L, Stenson BJ (2006) Effect of delayed sampling on umbilical cord arterial and venous lactate and blood gases in clamped and unclamped vessels. Arch Dis Child Fetal Neonatal 91:342–345CrossRef
Metadata
Title
Umbilical cord blood acid–base and gas analysis after early versus delayed cord clamping in neonates at term
Authors
Catalina De Paco
Jesús Florido
Mari Carmen Garrido
Sonia Prados
Luis Navarrete
Publication date
01-05-2011
Publisher
Springer-Verlag
Published in
Archives of Gynecology and Obstetrics / Issue 5/2011
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-010-1516-z

Other articles of this Issue 5/2011

Archives of Gynecology and Obstetrics 5/2011 Go to the issue

Materno-fetal Medicine

Ruptured uterus: the unabating obstetric catastrophe in South eastern Nigeria

Erratum

Erratum to: Laparoscopy-to-laparotomy quotient in obstetrics and gynecology residency programs

General Gynecology

The value of urocortin and Ca-125 in the diagnosis of endometrioma

Materno-fetal Medicine

Non-surgical management of ectopic pregnancy: appropriate risk management must be in place

General Gynecology

Patients’ awareness of postoperative adhesions: results from a multi-centre study and online survey

General Gynecology

Laparoscopy-to-laparotomy quotient in obstetrics and gynecology residency programs