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01-04-2011 | Materno-fetal Medicine

Association between tobacco use in pregnancy and placenta-associated syndromes: a population-based study

Authors: Muktar H. Aliyu, O’Neil Lynch, Ronee E. Wilson, Amina P. Alio, Sibylle Kristensen, Phillip J. Marty, Valerie E. Whiteman, Hamisu M. Salihu

Published in: Archives of Gynecology and Obstetrics | Issue 4/2011

Abstract

Introduction

Cigarette smoking is an established risk factor for adverse perinatal outcomes. The purpose of this study is to examine the association between maternal smoking in pregnancy and the occurrence of placental-associated syndromes (PAS).

Methods

We analyzed data from a population-based retrospective cohort of singleton deliveries that occurred in the state of Missouri from 1989 through 2005 (N = 1,224,133). The main outcome was PAS, a composite outcome defined as the occurrence of placental abruption, placenta previa, preeclampsia, small for gestational age, preterm or stillbirth. We used logistic regression models to generate adjusted odd ratios and their 95 percent confidence intervals. Non-smoking gravidas served as the referent category.

Results

The overall prevalence of prenatal smoking was 19.6%. Cigarette smoking in pregnancy was associated with the composite outcome of placental syndromes (odds ratio, 95% confidence interval = 1.59, 1.57–1.60). This association showed a dose–response relationship, with the risk of PAS increasing with increased quantity of cigarettes smoked. Similar results were observed between smoking in pregnancy and independent risks for abruption, previa, SGA, stillbirth, and preterm delivery.

Conclusion

Maternal smoking in pregnancy is a risk factor for the development of placenta-associated syndrome. Smoking cessation interventions in pregnancy should continue to be encouraged in all maternity care settings.

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Title: Association between tobacco use in pregnancy and placenta-associated syndromes: a population-based study
Authors: Muktar H. Aliyu
O’Neil Lynch
Ronee E. Wilson
Amina P. Alio
Sibylle Kristensen
Phillip J. Marty
Valerie E. Whiteman
Hamisu M. Salihu
Publication date: 01-04-2011
Publisher: Springer-Verlag
Published in: Archives of Gynecology and Obstetrics / Issue 4/2011
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-010-1447-8

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Association between tobacco use in pregnancy and placenta-associated syndromes: a population-based study

Abstract

Introduction

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusion

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