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Published in: Archives of Gynecology and Obstetrics 2/2011

01-02-2011 | Short Communication

Polycythemia vera and pregnancy: experience of four pregnancies in a single patient

Authors: Neelam Aggarwal, Seema Chopra, Vanita Suri, Pooja Sikka, Aditi Goundan, Pankaj Malhotra

Published in: Archives of Gynecology and Obstetrics | Issue 2/2011

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Abstract

Introduction

The association of polycythemia vera (PV) and pregnancy is rare. The estimated incidence ranges from 0.04 per 100,000 in women aged 20–34 years to 0.25 per 100,000 in those aged 35–39 years. The management of pregnant patient with PV may be problematic; less than 50 pregnancies have been reported so far in PV.

Material and methods

We hereby describe four pregnancies in a woman where PV was diagnosed in the fourth pregnancy. Aspirin and phlebotomy were used to maintain cell count in normal range and to avoid thrombotic complications.

Conclusion

Pregnancy in PV appears to be associated with significantly better outcome with tailor-made management for achieving good hematocrit control, low-dose aspirin and good maternal and fetal surveillance.
Literature
1.
go back to reference Tefferi A, Barbui T (2005) bcr/abl negative, classic myeloproliferative disorders: diagnosis and treatment. Mayo Clin Proc 80:120–1232 Tefferi A, Barbui T (2005) bcr/abl negative, classic myeloproliferative disorders: diagnosis and treatment. Mayo Clin Proc 80:120–1232
2.
3.
go back to reference Mc Nally RJ, Roman E, Cartweight RA (1999) Leukemias and lymphomas: time trends in the UK, 1984–93. Cancer Causes Control 10:35–42CrossRef Mc Nally RJ, Roman E, Cartweight RA (1999) Leukemias and lymphomas: time trends in the UK, 1984–93. Cancer Causes Control 10:35–42CrossRef
4.
go back to reference Subtil D, Deruella P, Trillot N, Jude B (2001) Preclinical phase of polycythemia vera in pregnancy. Obstet Gynecol 98:945–947CrossRefPubMed Subtil D, Deruella P, Trillot N, Jude B (2001) Preclinical phase of polycythemia vera in pregnancy. Obstet Gynecol 98:945–947CrossRefPubMed
5.
go back to reference Dllek TUK, Oktem M, Yildiz A (2004) Polycythemia vera and pregnancy. Int J Gyn Obst 85:161–162CrossRef Dllek TUK, Oktem M, Yildiz A (2004) Polycythemia vera and pregnancy. Int J Gyn Obst 85:161–162CrossRef
6.
go back to reference Harrison C (2005) Pregnancy and its management in the Philadelphia negative myeloproliferative diseases. Br J Haematol 129:293–306CrossRefPubMed Harrison C (2005) Pregnancy and its management in the Philadelphia negative myeloproliferative diseases. Br J Haematol 129:293–306CrossRefPubMed
7.
go back to reference Griesshammer M, Struve S, Harrison CM (2006) Essential thrombocythemia/polycythemia vera and pregnancy: the need for an observational study in Europe. Semin Thromb Haemost 32:422–429CrossRef Griesshammer M, Struve S, Harrison CM (2006) Essential thrombocythemia/polycythemia vera and pregnancy: the need for an observational study in Europe. Semin Thromb Haemost 32:422–429CrossRef
8.
go back to reference Barbui T, Finazzi G (2006) Myeloproliferative disease in pregnancy and other management issues. Hematology Am Soc Hematol Educ Program 2006;246–252 Barbui T, Finazzi G (2006) Myeloproliferative disease in pregnancy and other management issues. Hematology Am Soc Hematol Educ Program 2006;246–252
9.
go back to reference Robinson S, Bewley S, Hunt BJ, Radia DH, Harrison CN (2005) The management and outcome of 18 pregnancies in women with polycythemia vera. Haematologica 90:1477–1483PubMed Robinson S, Bewley S, Hunt BJ, Radia DH, Harrison CN (2005) The management and outcome of 18 pregnancies in women with polycythemia vera. Haematologica 90:1477–1483PubMed
10.
Metadata
Title
Polycythemia vera and pregnancy: experience of four pregnancies in a single patient
Authors
Neelam Aggarwal
Seema Chopra
Vanita Suri
Pooja Sikka
Aditi Goundan
Pankaj Malhotra
Publication date
01-02-2011
Publisher
Springer-Verlag
Published in
Archives of Gynecology and Obstetrics / Issue 2/2011
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-010-1446-9

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