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Archives of Gynecology and Obstetrics

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01-02-2011 | Materno-fetal Medicine

Outcome of severe preeclampsia manifested as nephrotic syndrome

Authors: Qiang Wei, Li Zhang, Xinghui Liu

Published in: Archives of Gynecology and Obstetrics | Issue 2/2011

Abstract

Objectives

To discuss the clinical features of severe preeclampsia and its outcome manifested as nephrotic syndrome (NSP).

Methods

Clinical data of 22 NSP patients treated in our hospital from January 2003 to March 2008 were collected to retrospectively analyze the blood pressure, serum albumin, urea nitrogen, cholesterol, 24 h urine protein, etc. before and after pregnancy.

Results

(1) The outcome of pregnant women: the blood pressure of patients in all 22 cases recovered within 6 weeks; edema usually regressed within 6 weeks, however, only 1 patient recovered on week 10; urine protein usually disappeared within 6 weeks, however, it kept remaining in the urine of patients in 2 cases after 10 weeks; the recovery of blood lipid, serum uric acid and plasma albumin often occurred within 4–10 weeks, while only a few patients did not recover; no pregnant woman died, indicating good prognosis. (2) The outcome of perinatal infant: 7 perinatal infants died (31.8%), and 9 neonatal infants were asphyxiated (40.9%), and 15 neonatal infants with low weight were born (68.2%).

Conclusions

All indexes of NSP patients usually recovered within 6 weeks after pregnancy cessation.

Cunningham FG, Hauth JC, Leveno KJ et al (2005) Williams obstetrics. McGraw-Hill Medical Publishing Division, New York

Medina Lomeli JM, Medina Castro N (2005) Differences and similarities of preeclampsia and gestational hypertension. Ginecol Obstet Mex 73(1):48–53PubMed

Maynard SE, Min JY, Merchan J et al (2003) Excess placental soluble fmslike tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest 111(5):600–602

Yamamoto T (2004) Secondary nephritic syndrome due to preeclampsia. Nippon Rinsho 62(10):1935–1940PubMed

Magriples U, Laifer S, Haysltt JP (2001) Dilutional hyponatremia in preeclampsia with and without nephrotic syndrome. Am J Obstet Gynecol 184:231–232CrossRefPubMed

Sibai B, Dekker G, Kupferminc M (2005) Preeclampsia. Lancet 365:785–799PubMed

Sibai BM, Ewell M, Levine RJ et al (1997) Risk factors associated with preeclampsia in healthy nulliparous women. The Calcium for Preeclampsia Prevention (CPEP) Study Group. Am J Obstet Gynecol 177:1003–1010CrossRefPubMed

Buhimschi CS, Norwitz ER, Funai E et al (2005) Urinary angiogenic factors cluster hypertensive disorders and identify women with severe preeclampsia. Am J Obstet Gynecol 192(3):734–741CrossRefPubMed

Dekker G, Robillard PY (2007) Preeclampsia: is the immune maladaptation hypothesis still standing? An epidemiological update. J Reprod Immunol 76:8–16CrossRefPubMed

10.

Moffett A, Hiby SE (2007) How does the maternal immune system contribute to the development of preeclampsia? Placenta 28(Suppl A):S51–S56CrossRefPubMed

11.

Dekker G (2002) The partner’s role in the etiology of preeclampsia. J Reprod Immunol 57:203–215CrossRefPubMed

12.

Murakami S, Saitoh M, Kubo T et al (2000) Renal disease in women with severe preeclampsia or gestational proteinuria. Obstet Gynecol 96(6):945–949CrossRefPubMed

13.

Crew RJ, Radhakrishnan J, Appel G (2004) Complications of the nephritic syndrome and their treatment. Clin Nephrol 62(4):245–259PubMed

14.

Nishimoto K, Shiiki H, Nishino T et al (1999) Glomerular hypertrophy in preeclamptic patients with focal segmental glomerulosclerosis. A morphometric analysis. Clin Nephrol 51:209–219PubMed

15.

Landau R, Irion O (2005) Recent data on the physiopathology of preeclampsia and recommendations for treatment. Rev Med Suisse 1(4):292–295

16.

Imasawa T, Nishiwaki T, Nishimura M et al (2006) A case of “pure” preeclampsia with nephrotic syndrome before 15 weeks of gestation in a patient whose renal biopsy showed glomerular capillary endotheliosis. Am J Kidney Dis 48(3):495–501CrossRefPubMed

17.

Shiiki H, Dohi K, Hanatani M et al (1990) Focal and segmental glomerulosclerosis in preeclampsia patients with nephrotic syndrome. Am J Nephrol 10:205–212CrossRefPubMed

Title: Outcome of severe preeclampsia manifested as nephrotic syndrome
Authors: Qiang Wei
Li Zhang
Xinghui Liu
Publication date: 01-02-2011
Publisher: Springer-Verlag
Published in: Archives of Gynecology and Obstetrics / Issue 2/2011
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-009-1338-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Outcome of severe preeclampsia manifested as nephrotic syndrome

Abstract

Objectives

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

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