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Archives of Gynecology and Obstetrics

Published in:

01-02-2011 | Materno-fetal Medicine

Calprotectin, RAGE and TNF-α in hypertensive disorders in pregnancy: expression and significance

Authors: Chong Feng, Yongjian Tao, Tao Shang, Miao Yu

Published in: Archives of Gynecology and Obstetrics | Issue 2/2011

Abstract

Objective

To investigate the expression of calprotectin, the receptor of advanced glycation end products (RAGE) and tumor necrosis factor-α (TNF-α) in hypertensive disorders in pregnancy as well as the significance of their expression.

Methods

The research assessed levels of plasma calprotectin and TNF-α using the enzyme-linked immunosorbent assay, and expression of calprotectin, RAGE and TNF-α in placenta tissues using the immunohistochemistry streptavidin–peroxidase (S–P) method in 60 women with hypertensive disorders in pregnancy and 32 women with normal pregnancy (as the controls).

Results

Compared with the control group, the levels of calprotectin, RAGE and TNF-α were elevated in plasma or placenta tissues in the group with hypertensive disorders in pregnancy, and were positively correlated with severity of hypertensive disorders in pregnancy. The levels of calprotectin were consistent with TNF-α in plasma and placenta tissues in the group with hypertensive disorders in pregnancy.

Conclusion

Changes in calprotectin, RAGE and TNF-α levels in maternal serum and placental tissue correlate to the pathogenesis and disease progression of hypertensive disorders in pregnancy.

Corrêa RR, Gilio DB, Cavellani CL et al (2008) Placental morphometrical and histopathology changes in the different clinical presentations of hypertensive syndromes in pregnancy. Arch Gynecol Obstet 277(3):201–206CrossRefPubMed

Johne B, Fagerhol MK, Lyberg T, Prydz H, Brandtzaeg P, Naess-Andresen CF, Dale I (1997) Functional and clinical aspects of the myelomonocyte protein calprotectin. Mol Pathol 50(3):113–123CrossRefPubMed

Turovskaya O, Foell D, Sinha P, Vogl T, Newlin R, Nayak J, Nguyen M, Olsson A, Nawroth PP, Bierhaus A, Varki N, Kronenberg M, Freeze HH, Srikrishna G (2008) RAGE, carboxylated glycans and S100A8/A9 play essential roles in colitis-associated carcinogenesis. Carcinogenesis 29(10):2035–2043CrossRefPubMed

Apel-Sarid L, Levy A, Holcberg G, Sheiner E (2009) Placental pathologies associated with intra-uterine fetal growth restriction complicated with and without oligohydramnios. Arch Gynecol Obstet 280(4):549–552CrossRefPubMed

Feinshtein V, Ben-Zvi Z, Sheiner E, Amash A, Sheizaf B, Holcberg G (2009) Progesterone levels in cesarean and normal delivered term placentas. Arch Gynecol Obstet

Polachek H, Holcberg G, Polachek J, Rubin M, Feinshtein V, Sheiner E, Ben-Zvi Z (2009) Carrier-mediated uptake of levofloxacin by BeWo cells, a human trophoblast cell line. Arch Gynecol Obstet

Roberts JM, Lain KY (2002) Recent insights into the pathogenesis of pre-eclampsia. Placenta 23(5):359–372CrossRefPubMed

Faas MM, Schuiling GA, Baller JF, Visscher CA, Bakker WW (1994) A new animal model for human preeclampsia: ultra-low-dose endotoxin infusion in pregnant rats. Am J Obstet Gynecol 171(1):158–164PubMed

Sharma A, Satyam A, Sharma JB (2007) Leptin, IL-10 and inflammatory markers (TNF-alpha, IL-6 and IL-8) in pre-eclamptic, normotensive pregnant and healthy non-pregnant women. Am J Reprod Immunol 58(1):21–30CrossRefPubMed

10.

Romero R, Espinoza J, Gonçalves LF, Kusanovic JP, Friel L, Hassan S (2007) The role of inflammation and infection in preterm birth. Semin Reprod Med 25(1):21–39CrossRefPubMed

11.

Romero R, Espinoza J, Mazor M (2004) Can endometrial infection/inflammation explain implantation failure, spontaneous abortion, and preterm birth after in vitro fertilization? Fertil Steril 82(4):799–804CrossRefPubMed

12.

Hsu CD, Witter FR (1995) Urogenital infection in preeclampsia. Int J Gynaecol Obstet 49(3):271–275CrossRefPubMed

13.

Canakci V, Canakci CF, Canakci H, Canakci E, Cicek Y, Ingec M, Ozgoz M, Demir T, Dilsiz A, Yagiz H (2004) Periodontal disease as a risk factor for pre-eclampsia: a case control study. Aust NZ J Obstet Gynaecol 44(6):568–573CrossRef

14.

Herrera JA, Chaudhuri G, López-Jaramillo P (2001) Is infection a major risk factor for preeclampsia? Med Hypotheses 57(3):393–397CrossRefPubMed

15.

Redman CW, Sacks GP, Sargent IL (1999) Preeclampsia: an excessive maternal inflammatory response to pregnancy. Am J Obstet Gynecol 180(2):499–506CrossRefPubMed

16.

Passey RJ, Xu K, Hume DA, Geczy CL (1999) S100A8: emerging functions and regulation. J Leukoc Biol 66(4):549–556PubMed

17.

Kerkhoff C, Klempt M, Sorg C (1998) Novel insights into structure and function of MRP8 (S100A8) and MRP14 (S100A9). Biochim Biophys Acta 1448(2):200–211CrossRefPubMed

18.

Yui S, Nakatani Y, Mikami M (2003) Calprotectin (S100A8/S100A9), an inflammatory protein complex from neutrophils with a broad apoptosis-inducing activity. Biol Pharm Bull 26(6):753–760CrossRefPubMed

19.

Stríz I, Trebichavský I (2004) Calprotectin—a pleiotropic molecule in acute and chronic inflammation. Physiol Res 53(3):245–253PubMed

20.

Hung TH, Charnock-Jones DS, Skepper JN et al (2004) Secretion Of tumor necrosis factor-alpha from human placental tissues induced by hypoxia-reoxygenation causes endothelial cell activation in vitro: a potential mediator of the inflammatory response in preeclampsia. Am J Pathol 164(3):1049–1061PubMed

21.

Nakagami H, Cui TX, Iwai M, Shiuchi T, Takeda-Matsubara Y, Wu L, Horiuchi M (2002) Tumor necrosis factor-alpha inhibits growth factor-mediated cell proliferation through SHP-1 activation in endothelial cells. Arterioscler Thromb Vasc Biol 22(2):238–242CrossRefPubMed

22.

Vince GS, Starkey PM, Austgulen R, Kwiatkowski D, Redman CW (1995) Interleukin-6, tumour necrosis factor and soluble tumour necrosis factor receptors in women with pre-eclampsia. Br J Obstet Gynaecol 102(1):20–25CrossRefPubMed

23.

Reister F, Frank HG, Kingdom JC, Heyl W, Kaufmann P, Rath W, Huppertz B (2001) Macrophage-induced apoptosis limits endovascular trophoblast invasion in the uterine wall of preeclamptic women. Lab Invest 81(8):1143–1152PubMed

24.

Laivuori H, Kaaja R, Koistinen H et al (2000) Leptin during and after preeclamptic or normal pregnancy: its relation to serum insulin and insulin sensitivity. Metabolism 49(2):259–263CrossRefPubMed

25.

Knackstedt M, Ding JW, Arck PC et al (2001) Activation of the novel prothrombinase, fg12, as a basis for the pregnancy complications spontaneous abortion and pre-eclampsia. Am J Reprod Immunol 46(3):196–210CrossRefPubMed

26.

Larsson PT, Hallerstam S, Rosfors S et al (2005) Circulating markers of inflammation are related to carotid artery atherosclerosis. Int Angiol 24(1):43–51PubMed

27.

Newton RA, Hogg N (1998) The human S100 protein MRP-14 is a novel activator of the beta 2 integrin Mac-1 on neutrophils. J Immunol 160(3):1427–1435PubMed

Title: Calprotectin, RAGE and TNF-α in hypertensive disorders in pregnancy: expression and significance
Authors: Chong Feng
Yongjian Tao
Tao Shang
Miao Yu
Publication date: 01-02-2011
Publisher: Springer-Verlag
Published in: Archives of Gynecology and Obstetrics / Issue 2/2011
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-009-1303-x

At a glance: The STEP trials

Springer Medicine

Calprotectin, RAGE and TNF-α in hypertensive disorders in pregnancy: expression and significance

Abstract

Objective

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Objective

Methods

Results

Conclusion

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