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Archives of Gynecology and Obstetrics

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01-05-2010 | Gynecologic Oncology

Umbilical cord blood amino-terminal pro-brain natriuretic peptide levels according to the mode of delivery

Authors: Won Joon Seong, Douk Hun Yoon, Gun Oh Chong, Dae Gy Hong, Tae Bon Koo, Taek Hoo Lee, Sang Sik Chun

Published in: Archives of Gynecology and Obstetrics | Issue 5/2010

Abstract

Purpose

To evaluate cord blood amino-terminal pro-brain natriuretic peptide (NT-proBNP) levels according to the mode of delivery.

Method

Between 1 March and 31 May 2007, 106 blood samples were drawn from the umbilical vein at the time of delivery. Eighty-four NT-proBNP levels [63 term (34 cesarean sections and 29 vaginal deliveries) and 21 preterm births] were analyzed with respect to gestational age, birth weight, Apgar score, newborn gender, and cord blood pH.

Results

There was no statistical significance on comparison of the mean NT-proBNP values between the cesarean and vaginal delivery groups (801.9 ± 537.7 vs. 724.3 ± 542.4 pg/ml, respectively; P = 0.572). The correlation of NT-proBNP with gestational age, birth weight, and cord blood pH was −0.616, −0.585, and −0.202, respectively. The mean values for NT-proBNP levels were compared according to the newborn gender (male vs. female; P = 0.926), and Apgar score at 1 min [>6 (N = 71) vs. ≤6 (N = 13); P = 0.001].

Conclusion

Vaginal delivery did not result in increased cord blood NT-proBNP levels reflecting cardiovascular stress to the fetal heart. NT-proBNP was inversely correlated with gestational age. Low Apgar score and umbilical cord blood pH appeared to induce the fetus to produce increased amounts of NT-proBNP.

Longo LD, Dale PS, Gilbert RD (1986) Uteroplacental O₂ uptake: continuous measurements during uterine quiescence and contractions. Am J Physiol 250:1099–1107

Takahashi Y, Iwagaki S, Nakagawa Y, Kawabata I, Tamaya T (2003) Uterine contractions increase fetal heart preload. Ultrasound Obstet Gynecol 22:53–56CrossRefPubMed

Bakker PC, van Geijn HP (2008) Uterine activity: implications for the condition of the fetus. J Perinat Med 36:30–37CrossRefPubMed

Cheung BM, Brown MJ (1994) Plasma brain natriuretic peptide and C-type natriuretic peptide in essential hypertension. J Hypertens 12:449–454CrossRefPubMed

Hunt PJ, Richards AM, Nicholls MG, Yandle TG, Doughty RN, Espiner EA (1997) Immunoreactive amino-terminal pro-brain natriuretic peptide (NT-PROBNP): a new marker of cardiac impairment. Clin Endocrinol (Oxf) 47:287–296CrossRef

Bhatia V, Nayyar P, Dhindsa S (2003) Brain natriuretic peptide in diagnosis and treatment of heart failure. J Postgrad Med 49:182–185PubMed

Cameron VA, Ellmers LJ (2003) Minireview: natriuretic peptides during development of the fetal heart and circulation. Endocrinology 144:2191–2194CrossRefPubMed

Maisel A (2002) B-type natriuretic peptide measurements in diagnosing congestive heart failure in the dyspneic emergency department patient. Rev Cardiovasc Med 3:S10–S17PubMed

Mair J, Gerda F, Renate H, Ulmer H, Andrea G, Pachinger O (2008) Head-to-head comparison of B-type natriuretic peptide (BNP) and NT-proBNP in daily clinical practice. Int J Cardiol 124:244–246CrossRefPubMed

10.

Furuhashi N, Kimura H, Nagae H, Yajima A, Kimura C, Saito T (1994) Brain natriuretic peptide and atrial natriuretic peptide levels in normal pregnancy and preeclampsia. Gynecol Obstet Invest 38:73–77CrossRefPubMed

11.

Itoh H, Sagawa N, Nanno H, Mori T, Mukoyama M, Itoh H et al (1997) Impaired guanosine 3′, 5′-cyclic phosphate production in severe pregnancy-induced hypertension with high plasma levels of atrial and brain natriuretic peptides. Endocr J 44:389–393CrossRefPubMed

12.

Kale A, Kale E, Yalinkaya A, Akdeniz N, Canoruç N (2005) The comparison of amino-terminal probrain natriuretic peptide levels in preeclampsia and normotensive pregnancy. J Perinat Med 33:121–124CrossRefPubMed

13.

Resnik JL, Hong C, Resnik R, Kazanegra R, Beede J, Bhalla V et al (2005) Evaluation of B-type natriuretic peptide (BNP) levels in normal and preeclamptic women. Am J Obstet Gynecol 193:450–454CrossRefPubMed

14.

Cameron VA, Aitken GD, Ellmers LJ, Kennedy MA, Espiner EA (1996) The sites of gene expression of atrial, brain, and C-type natriuretic peptide in mouse fetal development: temporal changes in embryos and placenta. Endocrinology 137:817–824CrossRefPubMed

15.

Mir TS, Laux R, Hellwege HH, Liedke B, Heinze C, von Buelow H et al (2003) Plasma concentrations of aminoterminal pro atrial natriuretic peptide and aminoterminal pro brain natriuretic peptide in healthy neonates: marked and rapid increase after birth. Pediatrics 112:896–899CrossRefPubMed

16.

Schwachtgen L, Herrmann M, Georg T, Schwarz P, Marx N, Lindinger A (2005) Reference values of NT-proBNP serum concentrations in the umbilical cord blood and in healthy neonates and children. Z Kardiol 94:399–404CrossRefPubMed

17.

Mannarino S, Ciardelli L, Garofoli F, Perotti G, Mongini E, Damiano S et al (2009) Correlation between cord blood, perinatal BNP values and echocardiographic parameters in healthy Italian newborns. Early Hum Dev 85:13–17CrossRefPubMed

18.

Walther T, Stepan H, Faber R (2001) Dual natriuretic peptide response to volume load in the fetal circulation. Cardiovasc Res 49:817–819CrossRefPubMed

19.

Halse KG, Lindegaard ML, Goetze JP, Damm P, Mathiesen ER, Nielsen LB (2005) Increased plasma pro-B-type natriuretic peptide in infants of women with type 1 diabetes. Clin Chem 51:2296–2302CrossRefPubMed

20.

Itoh H, Sagawa N, Hasegawa M, Okagaki A, Inamori K, Ihara Y et al (1993) Brain natriuretic peptide levels in the umbilical venous plasma are elevated in fetal distress. Biol Neonate 64:18–25CrossRefPubMed

21.

Fleming SM, O’Gorman T, O’Byrne L, Grimes H, Daly KM, Morrison JJ (2001) Cardiac troponin I and N-terminal pro-brain natriuretic peptide in umbilical artery blood in relation to fetal heart rate abnormalities during labor. Pediatr Cardiol 22:393–396PubMed

22.

Ohara R, Kawamoto M, Okada K, Yuge O (1996) Serial changes of atrial natriuretic peptide and brain natriuretic peptide during cesarean section under spinal anesthesia. Masui 45:1209–1211PubMed

23.

Arnaout L, Ghiglione S, Figueiredo S, Mignon A (2008) Effects of maternal analgesia and anesthesia on the fetus and the newborn. J Gynecol Obstet Biol Reprod (Paris) 37:S46–S55

24.

Bar-Oz B, Lev-Sagie A, Arad I, Salpeter L, Nir A (2005) N-terminal pro-B-type natriuretic peptide concentrations in mothers just before delivery, in cord blood, and in newborns. Clin Chem 51:926–927CrossRefPubMed

25.

Bakker J, Gies I, Slavenburg B, Bekers O, Delhaas T, van Dieijen-Visser M (2004) Reference values for N-terminal pro-B-type natriuretic peptide in umbilical cord blood. Clin Chem 50:2465CrossRefPubMed

26.

Fortunato G, Carandente Giarrusso P, Martinelli P, Sglavo G, Vassallo M, Tomeo L et al (2006) Cardiac troponin T and amino-terminal pro-natriuretic peptide concentrations in fetuses in the second trimester and in healthy neonates. Clin Chem Lab Med 44:834–836CrossRefPubMed

Title: Umbilical cord blood amino-terminal pro-brain natriuretic peptide levels according to the mode of delivery
Authors: Won Joon Seong
Douk Hun Yoon
Gun Oh Chong
Dae Gy Hong
Tae Bon Koo
Taek Hoo Lee
Sang Sik Chun
Publication date: 01-05-2010
Publisher: Springer-Verlag
Published in: Archives of Gynecology and Obstetrics / Issue 5/2010
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-009-1253-3

At a glance: The STEP trials

Springer Medicine

Umbilical cord blood amino-terminal pro-brain natriuretic peptide levels according to the mode of delivery

Abstract

Purpose

Method

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Method

Results

Conclusion

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