Top

Archives of Gynecology and Obstetrics

Published in:

01-03-2010 | Reproductive Medicine

The effect of retrieved oocyte count on pregnancy outcomes in an assisted reproduction program

Authors: Tevfik Yoldemir, Ian S. Fraser

Published in: Archives of Gynecology and Obstetrics | Issue 3/2010

Abstract

Objective

To determine if women with less than five eggs retrieved do as well as women with more eggs retrieved in terms of pregnancy outcomes in our assisted reproduction program.

Method

Two hundred one women undergoing in vitro fertilization treatment at Fertility Unit in Royal Prince Alfred Hospital, University of Sydney, Australia were selected for retrospective evaluation. The women were grouped according to the number of oocytes retrieved at ovum pick-up. Group A consisted of women with less than 5 oocytes, group B with 5 to 10 oocytes and group C with 11 to 15 oocytes collected. Clinical and ongoing pregnancy rates were compared.

Results

There was no difference between the groups in terms of clinical and ongoing pregnancy rates.

Conclusion

With good IVF lab conditions, if a patient reaches embryo transfer, the number of eggs retrieved should not affect the likelihood of pregnancy outcome in an assisted reproductive technology treatment.

Fasouliotis SJ, Simon A, Laufer N (2000) Evaluation and treatment of low responders in assisted reproductive technology: a challenge to meet. J Assist Reprod Genet 17:357–373CrossRefPubMed

Tarlatzis BC, Zepiridis L, Grimbizis G, Bontis J (2003) Clinical management of low ovarian response to stimulation for IVF: a systematic review. Hum Reprod Update 9:61–76CrossRefPubMed

Surrey ES, Schoolcraft WB (2000) Evaluating strategies for improving ovarian response of the poor responder undergoing assisted reproductive techniques. Fertil Steril 73:667–676CrossRefPubMed

Mahutte NG, Arici A (2002) Poor responders: does the protocol make a difference? Curr Opin Obstet Gynecol 14:275–281CrossRefPubMed

Serafini P, Stone B, Kerin J (1988) An alternative approach to controlled ovarian hyperstimulation in ‘poor responders’ with a gonadotrophin releasing hormone analog. Fertil Steril 49:90–95PubMed

Jenkins JM, Davies DW, Devonport H (1991) Comparison of ‘poor responders’ with ‘good responders’ using a standard buserelin/human menopausal gonadotrophin regime for in-vitro fertilisation. Hum Reprod 6:918–921PubMed

Land J, Yarmolinskaya M, Dumoulin J, Evers J (1996) High-dose human menopausal gonadotropin stimulation in poor responders does not improve in vitro fertilization outcome. Fertil Steril 65:961–965PubMed

Raga F, Bonilla-Musoles F, Casan EM, Bonilla F (1999) Recombinant follicle stimulating hormone stimulation in poor responders with normal basal concentrations of follicle stimulating hormone and oestradiol: improved reproductive outcome. Hum Reprod 14:1431–1434CrossRefPubMed

Surrey ES, Bower JA, Hill DM, Ramsey J, Surrey MW (1998) Clinical and endocrine effects of a microdose GnRH agonist flare regimen administered to poor responders who are undergoing in vitro fertilization. Fertil Steril 69:419–424CrossRefPubMed

10.

Fenichel P, Grimaldi M, Olivero JF (1989) Predictive value of hormone profiles before stimulation for in vitro fertilization. Fertil Steril 51:845–849PubMed

11.

Bancsi LF, Broekmans FJ, Eijkemans MJ, de Jong FH, Habbema JD, te Velde ER (2002) Predictors of poor ovarian response in in vitro fertilization: a prospective study comparing basal markers of ovarian reserve. Fertil Steril 77:328–336CrossRefPubMed

12.

Hendriks DJ, Mol BW, Bancsi LF, te Velde ER, Broekmans FJ (2005) Antral follicle count in the prediction of poor ovarian response and pregnancy after in vitro fertilization: a meta-analysis and comparison with basal follicle-stimulating hormone level. Fertil Steril 83:291–301CrossRefPubMed

13.

Mol BW, Verhagen TE, Hendriks DJ, Collins JA, Coomarasamy A, Opmeer BC (2006) Value of ovarian reserve testing before IVF: a clinical decision analysis. Hum Reprod 21:1816–1823CrossRefPubMed

14.

Farhi J, Homburg R, Ferber A (1997) Non-response to ovarian stimulation in normogonadotrophic, normogonadal women: a clinical sign of impending onset of ovarian failure pre-empting the rise in basal follicle stimulating hormone levels. Hum Reprod 12:241–243CrossRefPubMed

15.

Tanbo T, Dale PO, Lunde O (1992) Prediction of response to controlled ovarian hyperstimulation: a comparison of basal and clomiphene citrate-stimulated follicle-stimulating hormone levels. Fertil Steril 57:819–824PubMed

16.

Winslow KL, Toner JP, Brzyski RG (1991) The gonadotrophin releasing hormone agonist stimulation test—a sensitive predictor of performance in the flare-up in vitro fertilization cycle. Fertil Steril 56:711–717PubMed

17.

Franchin R, De Ziegler D, Olivennes F (1994) Exogenous follicle stimulating hormone ovarian reserve test (EFORT): a simple and reliable screening test for detecting ‘poor responders’ in in vitro fertilization. Hum Reprod 9:1607–1611

18.

Smotrich DB, Widra EA, Gindoff PR (1995) Prognostic value of day 3 estradiol on in vitro fertilization outcome. Fertil Steril 64:1136–1140PubMed

19.

Lass A, Skull J, McVeigh E (1997) Measurement of ovarian volume by transvaginal sonography before ovulation induction with human menopausal gonadotrophin for in-vitro fertilization can predict poor response. Hum Reprod 12:294–297CrossRefPubMed

20.

Tomas C, Nuojua-Huttunen S, Martikainen H (1997) Pretreatment transvaginal ultrasound examination predicts ovarian responsiveness to gonadotrophins in in-vitro fertilization. Hum Reprod 12:220–223CrossRefPubMed

21.

Zaidi J, Barber J, Kyei-Mensah A (1996) Relationship of ovarian stromal blood flow at the baseline ultrasound scan to subsequent follicular response in an in vitro fertilization program. Obstet Gynecol 88:779–784CrossRefPubMed

22.

Klinkert ER, Broekmans FJ, Looman CW, te Velde ER (2004) A poor response in the first in vitro fertilization cycle is not necessarily related to a poor prognosis in subsequent cycles. Fertil Steril 81:1247–1253CrossRefPubMed

23.

Kailasam C, Keay SD, Wilson P, Ford WCL, Jenkins JM (2004) Defining poor ovarian response during IVF cycles, in women aged <40 years, and its relationship with treatment outcome. Hum Reprod 19:1544–1547CrossRefPubMed

24.

Templeton A, Morris JK, Parslow W (1996) Factors that affect outcome of in-vitro fertilisation treatment. Lancet 348:1402–1406CrossRefPubMed

25.

Tarin JJ, Sampaio MC, Calatayud C, Castellvi RM, Bonilla-Musoles F, Pellicer A (1992) Relativity of the concept ‘high responder to gonadotrophins’. Hum Reprod 7:19–22PubMed

26.

Devreker F, Pogonici E, De Maertelaer V, Revelard P, Van den Bergh M, Englert Y (1999) Selection of good embryos for transfer depends on embryo cohort size: implications for ‘mild ovarian stimulation’ debate. Hum Reprod 14:3002–3008CrossRefPubMed

27.

Gregory L (1998) Ovarian markers of implantation potential in assisted reproduction. Hum Reprod 13(Suppl 4):117–132PubMed

28.

Lashen H, Ledger W, Lopez-Bernal A, Barlow D (1999) Poor responders to ovulation induction: is proceeding to in-vitro fertilization worthwhile? Hum Reprod 14:964–969CrossRefPubMed

Title: The effect of retrieved oocyte count on pregnancy outcomes in an assisted reproduction program
Authors: Tevfik Yoldemir
Ian S. Fraser
Publication date: 01-03-2010
Publisher: Springer-Verlag
Published in: Archives of Gynecology and Obstetrics / Issue 3/2010
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-009-1221-y

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

The effect of retrieved oocyte count on pregnancy outcomes in an assisted reproduction program

Abstract

Objective

Method

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Objective

Method

Results

Conclusion

Please log in to get access to this content

Other articles of this Issue 3/2010

Minilaparotomy in spinal anaesthesia: a surgical choice in treatment of benign gynaecologic disease

Archives of Gynecology and Obstetrics by the end of 2009

Acute pancreatitis associated with hypertriglyceridemia: a life-threatening complication

Acute abdomen due to rupture of Sertoli cell tumor

Intrauterine fetal bone retention after late-term abortion by external force in the 20th week of pregnancy

Conservative management of placenta increta after first trimester abortion by transcatheter arterial chemoembolization: a case report and review of the literature