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01-03-2010 | Gynecologic oncology

Prognostic significance of estrogen receptor alpha and beta expression in human serous carcinomas of the ovary

Authors: Alexander Burges, Ansgar Brüning, Christine Dannenmann, Thomas Blankenstein, Udo Jeschke, Naim Shabani, Klaus Friese, Ioannis Mylonas

Published in: Archives of Gynecology and Obstetrics | Issue 3/2010

Abstract

Background

Ovarian cancer is a gynecologic cancer with a high mortality rate. This shows the need of effective screening methods and reliable cancer markers for ovarian cancer staging and appropriate effective cancer treatment.

Methods

Expression of estrogen receptor α and β was studied by immunhistochemical analysis of 100 ovarian cancer tissue samples.

Results

In this study on 100 serous ovarian cancer tissue samples from patients with defined clinicopathologic features, a significant association of ER-α expression with ovarian cancer grading (p = 0.004), progression-free survival (p = 0.007), and cause-specific survival (p = 0.001) was demonstrated. Expression of ER-β was found to be associated with the metastatic lymph node status (p = 0.006).

Conclusion

Immunohistochemical analysis of ER might be used as an easy, simple and highly efficient marker to identify high-risk patients and may aid in the selection of patients for a more aggressive adjuvant therapy. Furthermore, patients that show a positive ER-α immunostaining can be selected for a specific anti-hormonal therapy, as already performed for breast cancer patients.

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Title: Prognostic significance of estrogen receptor alpha and beta expression in human serous carcinomas of the ovary
Authors: Alexander Burges
Ansgar Brüning
Christine Dannenmann
Thomas Blankenstein
Udo Jeschke
Naim Shabani
Klaus Friese
Ioannis Mylonas
Publication date: 01-03-2010
Publisher: Springer-Verlag
Published in: Archives of Gynecology and Obstetrics / Issue 3/2010
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-009-1185-y

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Prognostic significance of estrogen receptor alpha and beta expression in human serous carcinomas of the ovary

Abstract

Background

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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