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Archives of Gynecology and Obstetrics

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01-02-2010 | Case Report

Severe early onset hemolysis, elevated liver enzyme, and low platelet-syndrome in 2 subsequent pregnancies: case report and review of the literature

Authors: Johannes Ott, Gunda Poschalko, Harald Zeisler

Published in: Archives of Gynecology and Obstetrics | Issue 2/2010

Abstract

Background

Pregnancies after a previous pregnancy complicated by hemolysis, elevated liver enzyme, and low platelet (HELLP) syndrome carry an increased risk of HELLP-syndrome.

Case report

We report on a 35-year-old patient with both HELLP-syndrome and fatal neonatal outcome in two subsequent pregnancies with delivery by cesarean section in the 26th and 27th gestational weeks, respectively. The children were immediately admitted to the neonatal intensive care unit but died in their postpartum period. Before the second pregnancy testing for antiphospholipid-syndrome revealed normal results.

Conclusion

In general, pregnancies after HELLP-syndrome carry increased risks for pregnancy-related complications. Evaluation of the immunologic status and application of immune-globulins could be diagnostic and therapeutic options in our case. Further research is recommended to evaluate the mechanisms of recurrence of HELLP-syndrome.

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Title: Severe early onset hemolysis, elevated liver enzyme, and low platelet-syndrome in 2 subsequent pregnancies: case report and review of the literature
Authors: Johannes Ott
Gunda Poschalko
Harald Zeisler
Publication date: 01-02-2010
Publisher: Springer-Verlag
Published in: Archives of Gynecology and Obstetrics / Issue 2/2010
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-009-1176-z

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Severe early onset hemolysis, elevated liver enzyme, and low platelet-syndrome in 2 subsequent pregnancies: case report and review of the literature

Abstract

Background

Case report

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Case report

Conclusion

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