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Archives of Gynecology and Obstetrics

Published in:

01-05-2010 | Original Article

Altered gene profile of placenta from women with intrahepatic cholestasis of pregnancy

Authors: Jing Wei, Huimin Wang, Xiaofu Yang, Minyue Dong, Zhengping Wang

Published in: Archives of Gynecology and Obstetrics | Issue 5/2010

Abstract

Objectives

To investigate the alterations in gene profile of placenta from pregnant women with intrahepatic cholestasis of pregnancy (ICP) and to enhance the insight of etiology and pathogenesis of ICP.

Methods

Ten pregnant women diagnosed ICP were recruited and 10 healthy pregnant women served as control. Four samples were taken from each placenta and RNA was isolated. Gene expression was analyzed with microarray and real time PCR was used to validate the differentially expressed genes.

Results

392 genes were found differentially expressed. Among these differentially expressed genes, 280 were up-regulated and 112 were down-regulated. These differentially expressed genes involved 20 categories including genes involved in transportation, cell growth, apoptosis and immune response that were putatively participated the pathogenesis of ICP.

Conclusions

293 differentially expressed genes of 20 categories were found in ICP placenta, suggesting the diversity of gene expression alteration and the complexity of etiology and pathogenesis of ICP.

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Title: Altered gene profile of placenta from women with intrahepatic cholestasis of pregnancy
Authors: Jing Wei
Huimin Wang
Xiaofu Yang
Minyue Dong
Zhengping Wang
Publication date: 01-05-2010
Publisher: Springer-Verlag
Published in: Archives of Gynecology and Obstetrics / Issue 5/2010
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-009-1156-3

At a glance: The STEP trials

Springer Medicine

Altered gene profile of placenta from women with intrahepatic cholestasis of pregnancy

Abstract

Objectives

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

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