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01-09-2009 | Original Article

Status of essential trace metals in biological samples of diabetic mother and their neonates

Authors: Hassan Imran Afridi, Tasneem Gul Kazi, Naveed Kazi, Jamil Ahmed Baig, Mohammad Khan Jamali, Mohammad Balal Arain, Raja Adil Sarfraz, Hafeez-ur-Rehman Sheikh, Ghulam Abbas Kandhro, Abdul Qadir Shah

Published in: Archives of Gynecology and Obstetrics | Issue 3/2009

Abstract

Objective

There is accumulating facts that the metabolism of essential trace elements is altered in diabetic patients. The aim of present study was to compare the status of essential trace elements, chromium (Cr), manganese (Mn), and zinc (Zn) in biological samples (whole blood, urine and scalp hair) of insulin dependent diabetic mothers (age ranged 30–40) and their newly born infants (n = 76). An age matched 68 non-diabetic mothers and their infants, residing in the same locality, were selected as referents. For a comparative study, the biological samples of non-diabetic and diabetic pregnant and non pregnant of same age group and socio-economics status were also analysed.

Methodology

The biological samples (scalp hair, blood and urine) were collected from study and referent groups. The Cr, Mn and Zn concentrations in all three biological samples were determined by a flame/electrothermal atomic absorption spectrometer, prior to microwave assisted acid digestion. The validity and accuracy of the methodology was checked by certified reference materials (CRMs) and using conventional wet acid digestion method on same CRMs.

Results

The mean values of Cr, Mn and Zn in scalp hair and blood samples of diabetic mothers and their infants were significantly lower as compared to the referent mothers-infants pairs (p < 0.01), while urinary excretion of all these elements were high in diabetic mother–infant pair samples.

Conclusion

The deficiencies of essential trace elements, Cr, Mn and Zn in biological samples of diabetic women, may play role in the pathogenesis of diabetes mellitus and impacts on their neonates.

Gibson RS, Ferguson EL (1998) Assessment of dietary zinc in a population. Am J Clin Nutr 68:414–417

Volgoraev M (1987) Theoretical and clinical aspects of nutrition: assessing population supply with vitamins. VIII, Moscow, p 37

Spiritchev V (2000) How many vitamins one needs? Russian Medical Academy Institut Pitanya, Moscow, p 185

Ehmann WD, Vance DE (1996) Studies of trace element involvement in human disease by in vitro activation analysis. J Radioanal Nucl Chem 203:429–445. doi:10.1007/BF02041521 CrossRef

Srivastava S, Mehrotra PK, Srivastava SP, Siddiqui MKJ (2002) Some essential elements in maternal and cord blood in relation to birth weight and gestational age of the baby. Biol Trace Elem Res 86:97–105. doi:10.1385/BTER:86:2:097 PubMedCrossRef

Keen CL, Clegg MS, Hanna LA (2003) The plausibility of micronutrient deficiencies being a significant contributing factor to the occurrence of pregnancy complications. J Nutr 133:1597–1605

Catalano PM, Kirwan JP, Haugel-de Mouzon S, King J (2003) Gestational diabetes and insulin resistance: role in short- and long-term implications for mother and fetus. J Nutr 133:1674S–1683SPubMed

Al-Saleh E, Nandakumaran M, Al-Shammari M et al (2005) Maternal-fetal status of copper, iron, molybdenum, selenium and zinc in insulin-dependent diabetic pregnancies. Arch Gynecol Obstet 271:212–217. doi:10.1007/s00404-004-0636-8 PubMedCrossRef

Al-Saleh E, Nandakumaran M, Al-Shammari M et al (2004) Assessment of maternal-fetal status of some essential trace elements in pregnant women in late gestation: relationship with birth weight and placental weight. J Matern Fetal Neonatal Med 16:9–14PubMedCrossRef

10.

Cohen JJ, Duke RC, Fadok VA, Seilins KS (1992) Apoptosis and programmed cell death in immunity. Annu Rev Immunol 10:267–293. doi:10.1146/annurev.iy.10.040192.001411 PubMedCrossRef

11.

Caulfield LE, Zavaleta N, Shankar AH, Merialdi M (1998) Potential contribution pf maternal zinc supplementation during pregnancy to maternal and child survival. Am J Clin Nutr 68:499–509

12.

Lira PIC, Ashworth A, Morris SS (1998) Effect of zinc supplementation on the morbidity, immune function, and growth of low-birth, full-term infants in northeast Brazil. Am J Clin Nutr 68:418–424

13.

Zlotkin SH, Atkinson S, Lockitch G (1995) Trace elements in nutrition for premature infants. Clin Perinatol 22:223–240PubMed

14.

Nielsen FH (1994) Ultra trace minerals. In: Shils ME, Olson JA, Shike M (eds) Modern nutrition in health and disease, 8th edn. Lea & Febiger, Philadelphia, pp 269–286

15.

Wallach S, Verch L (1984) Placental transport of chromium. J Am Coll Nutr 3:69–74PubMed

16.

Mesko MF, Moraes DP, Barin JS (2006) Digestion of biological materials using the microwave-assisted sample combustion technique. Microchem J 82:183–188. doi:10.1016/j.microc.2006.01.004 CrossRef

17.

Kazi TG, Afridi HI, Kazi N (2008) Copper, chromium, manganese, iron, nickel, and zinc levels in biological samples of diabetes mellitus patients. Biol Trace Elem Res 122(1):1–18. doi:10.1007/s12011-007-8062-y PubMedCrossRef

18.

Afridi HI, Kazi TG, Kazi GH (2005) Determination of essential trace and toxic elements in hair samples of night blindness patients versus normal subjects. Am Biotechnol Lab 23(1):16–17

19.

Kazi TG, Afridi HI, Kazi GH (2006) Evaluation of essential and toxic metals by ultrasound-assisted acid leaching from scalp hair samples of children with macular degeneration patients. Clin Chim Acta 369:52–60. doi:10.1016/j.cca.2006.01.003 PubMedCrossRef

20.

Armitage P, Berry G (1994) Statistical methods in medical research, 3rd edn. Blackwell, Oxford

21.

Rathi SS, Srinivas M, Grover JK (1999) Zinc levels in women and newborns. Indian J Pediatr 66:681–684. doi:10.1007/BF02726254 PubMedCrossRef

22.

Aharoni A, Tesler B, Paltieli Y (1992) Hair chromium content of women with gestational diabetes compared with nondiabetic pregnant women. Am J Clin Nutr 55:l04–l07

23.

Smargiassi A, Takser L, Masse A (2002) A comparative study of manganese and lead levels in human umbilical cords and maternal blood from two urban centers exposed to different gasoline additives. Sci Total Environ 290:157–164. doi:10.1016/S0048-9697(01)01071-3 PubMedCrossRef

24.

Tsuchiya H, Shima S, Kurita H (1987) Effects of maternal exposure to six heavy metals on fetal development. Bull Environ Contam Toxicol 38:580–587. doi:10.1007/BF01608589 PubMedCrossRef

25.

Creason JP, Svendsgaard D, Bumgarner J (1976) Maternal-fetal tissue levels of 16 trace elements in 8 selected continental United States communities. In: Hemphill DD (ed) Trace substances in environmental health-X. University of Missouri, Columbia, pp 53–62

26.

UNICEF (2004) Vitamin and mineral deficiency: a global progress report

27.

United Nations Administrative Committee on Coordination/Sub-Committee on Nutrition (ACC/SCN) (2000) Fourth report on the world nutrition situation. Geneva: ACC/SCN in collaboration with International Food Policy Research Institute (IFPRI)

28.

Godfrey KM, Barker DJ (2000) Fetal nutrition and adult disease. Am J Clin Nutr 71(suppl):1344S–1352SPubMed

29.

Institute of Medicine (IOM) (1998) Prevention of micronutrient deficiencies: tools for policy makers and public health workers. National Academy Press, Washington

30.

Ivarez SIA, Castanon SG, Ruata MLC (2007) Updating of normal levels of copper, zinc and selenium in serum of pregnant women. J Trace Elem Med Biol 21:49–52. doi:10.1016/j.jtemb.2007.09.023 CrossRef

31.

Caulfield LE, Zavaleta N, Figueroa A, Leon Z (1999) Maternal zinc supplementation does not affect size at birth or pregnancy duration in Peru. J Nutr 129:1563–1568PubMed

32.

Merialdi M, Caulfield LE, Zavaleta N (2004) Randomized controlled trial of prenatal zinc supplementation and the development of fetal heart rate. Am J Obstet Gynecol 190:1106–1112. doi:10.1016/j.ajog.2003.09.072 PubMedCrossRef

33.

Deelstra H, Schoor OV, Robberecht H (1988) Daily chromium intake by infants in Belgium. Acta Paediatr Scand 77:402–407. doi:10.1111/j.1651-2227.1988.tb10667.x PubMedCrossRef

34.

Dorman DC, McElveen AM, Marshall MW (2005) Tissue manganese concentrations in lactating rats and their offspring following combined in utero and lactation exposure to inhaled manganese sulfate. Toxicol Sci 84:12–21. doi:10.1093/toxsci/kfi060 PubMedCrossRef

35.

Committee on Nutrition, American Academy of Pediatrics (1985) Nutritional needs of low birth weight infants. Pediatrics 75:976–986

36.

Committee on Nutrition, American Academy of Pediatrics (2003) In: Kleinman RE (ed) Pediatric nutrition handbook, 5th edn. Softcover, New York

37.

ASPEN Report (2004) Task force for the revision of safe practices for parenteral nutrition: Mirtallo J, Canada T, Johnson D, Kumpf V, Petersen C, Sacks G, Seres D, Guenter P. Special report: safe practices for parenteral. J Parenter Enteral Nutr 28:S39–S70

Title: Status of essential trace metals in biological samples of diabetic mother and their neonates
Authors: Hassan Imran Afridi
Tasneem Gul Kazi
Naveed Kazi
Jamil Ahmed Baig
Mohammad Khan Jamali
Mohammad Balal Arain
Raja Adil Sarfraz
Hafeez-ur-Rehman Sheikh
Ghulam Abbas Kandhro
Abdul Qadir Shah
Publication date: 01-09-2009
Publisher: Springer-Verlag
Published in: Archives of Gynecology and Obstetrics / Issue 3/2009
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-009-0955-x

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Status of essential trace metals in biological samples of diabetic mother and their neonates

Abstract

Objective

Methodology

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Objective

Methodology

Results

Conclusion

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