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Published in: Archives of Gynecology and Obstetrics 3/2009

01-03-2009 | Case Report

Twin pregnancy with a complete hydatidiform mole and co-existent live fetus: two case reports and review of the literature

Authors: Kenan Dolapcioglu, Arif Gungoren, Sibel Hakverdi, Ali Ulvi Hakverdi, Ertugrul Egilmez

Published in: Archives of Gynecology and Obstetrics | Issue 3/2009

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Abstract

Introduction

The aim of this study was to report the clinical features, management, and outcome of two cases of complete hydatidiform mole with a coexisting viable fetus and to review the literature.

Case reports

In this article, we report on the well-documented follow-up of two cases of twin pregnancies with complete hydatidiform mole and a normal fetus. Genetic amniocentesis showed normal fetal karyotype in both of two cases. In the first case, a live male infant was delivered by a cesarean section because of severe maternal bleeding at 29 weeks of gestation. In the second case, termination of pregnancy was performed due to early onset of severe preeclampsia and vaginal hemorrhage.

Conclusion

The chances of a live birth have been estimated between 30 and 35% and the risk of persistent trophoblastic disease is similar to singleton molar pregnancies in complete mole with coexisting fetus pregnancy. Therefore, in these pregnancies, expectant management instead of termination of pregnancy can be suggested.
Literature
1.
go back to reference Suzuki M, Matsunobu A, Wakita K, Nishijima M, Osanai K (1980) Hydatidiform mole with a surviving coexisting fetus. Obstet Gynecol 56:384–388PubMed Suzuki M, Matsunobu A, Wakita K, Nishijima M, Osanai K (1980) Hydatidiform mole with a surviving coexisting fetus. Obstet Gynecol 56:384–388PubMed
2.
go back to reference Vaisbuch E, Ben-Arie A, Dgani R, Perlman S, Sokolovsky N, Hagay Z (2006) Twin pregnancy consisting of a complete hydatidiform mole and co-existent fetus: report of two cases and review of literature. Gynecol Oncol 100:218–219. doi:10.1016/j.ygyno.2005.09.003 CrossRef Vaisbuch E, Ben-Arie A, Dgani R, Perlman S, Sokolovsky N, Hagay Z (2006) Twin pregnancy consisting of a complete hydatidiform mole and co-existent fetus: report of two cases and review of literature. Gynecol Oncol 100:218–219. doi:10.​1016/​j.​ygyno.​2005.​09.​003 CrossRef
4.
go back to reference Steller MA, Genest DR, Bernstein MR, Lage JM, Goldstein DP, Berkowitz RS (1994) Clinical features of multiple conception with partial or complete molar pregnancy and coexisting fetuses. J Reprod Med 39:147–154PubMed Steller MA, Genest DR, Bernstein MR, Lage JM, Goldstein DP, Berkowitz RS (1994) Clinical features of multiple conception with partial or complete molar pregnancy and coexisting fetuses. J Reprod Med 39:147–154PubMed
5.
go back to reference Vejerslev LO, Sunde L, Hansen BF, Larsen JK, Christensen IJ, Larsen G (1991) Hydatidiform mole and fetus with normal karyotype: support of a separate entity. Obstet Gynecol 77:868–874PubMed Vejerslev LO, Sunde L, Hansen BF, Larsen JK, Christensen IJ, Larsen G (1991) Hydatidiform mole and fetus with normal karyotype: support of a separate entity. Obstet Gynecol 77:868–874PubMed
7.
go back to reference Garbin O, Favre R, Weber P, Arbogast E, Gasser B (1995) How to deal with a rare entity: the coexistence of a complete mole and a healthy egg in twin pregnancy? Fetal Diagn Ther 10:337–342PubMedCrossRef Garbin O, Favre R, Weber P, Arbogast E, Gasser B (1995) How to deal with a rare entity: the coexistence of a complete mole and a healthy egg in twin pregnancy? Fetal Diagn Ther 10:337–342PubMedCrossRef
8.
go back to reference Ishii J, Iitsuka Y, Takano H, Matsui H, Osada H, Sekiya S (1998) Genetic differentiation of complete hydatidiform moles coexisting with normal fetuses by short tandem repeat derived deoxyribonucleic acid polymorphism analysis. Am J Obstet Gynecol 179:628–634. doi:10.1016/S0002-9378(98)70055-9 PubMedCrossRef Ishii J, Iitsuka Y, Takano H, Matsui H, Osada H, Sekiya S (1998) Genetic differentiation of complete hydatidiform moles coexisting with normal fetuses by short tandem repeat derived deoxyribonucleic acid polymorphism analysis. Am J Obstet Gynecol 179:628–634. doi:10.​1016/​S0002-9378(98)70055-9 PubMedCrossRef
11.
go back to reference Niemann I, Sunde L, Peterson LK (2007) Evaluation of the risk of persistent trophoblastic disease after twin pregnancy with diploid hydatidiform mole and coexisting normal fetus. Am J Obstet Gynecol 197:451–455CrossRef Niemann I, Sunde L, Peterson LK (2007) Evaluation of the risk of persistent trophoblastic disease after twin pregnancy with diploid hydatidiform mole and coexisting normal fetus. Am J Obstet Gynecol 197:451–455CrossRef
14.
go back to reference Shahabi S, Naome G, Cobin L, Veroughstruele A, Musters L, Zengbe V et al (1977) Complete hydatidiform mole and coexisting fetus. A case report of two cases with contrasting outcomes. J Reprod Med 42:756–760 Shahabi S, Naome G, Cobin L, Veroughstruele A, Musters L, Zengbe V et al (1977) Complete hydatidiform mole and coexisting fetus. A case report of two cases with contrasting outcomes. J Reprod Med 42:756–760
15.
go back to reference Block MF, Merill JA (1982) Hydatidifrom mole with coexistent fetus. Obstet Gynecol 60:129–134PubMed Block MF, Merill JA (1982) Hydatidifrom mole with coexistent fetus. Obstet Gynecol 60:129–134PubMed
16.
17.
go back to reference Jinno M, Ubukata Y, Hanya I, Satou M, Yoshimura Y, Nakamura Y (1994) Hydatidiform mole with a surviving coexistent fetus following in-vitro fertilization. Hum Reprod 9:1770–1772PubMed Jinno M, Ubukata Y, Hanya I, Satou M, Yoshimura Y, Nakamura Y (1994) Hydatidiform mole with a surviving coexistent fetus following in-vitro fertilization. Hum Reprod 9:1770–1772PubMed
18.
go back to reference Anderson CK, Deiter RWM, Motz MJ, Goldstein JA (1996) Complete hydatidiform mole with a coexistent healthy, viable fetus near term: a case report. J Reprod Med 41:55–58PubMed Anderson CK, Deiter RWM, Motz MJ, Goldstein JA (1996) Complete hydatidiform mole with a coexistent healthy, viable fetus near term: a case report. J Reprod Med 41:55–58PubMed
23.
27.
go back to reference Bovicelli L, Ghi T, Pilu G, Farina A, Savelli L, Simonazzi G et al (2004) Prenatal diagnosis of a complete mole coexisting with a dichorionic twin pregnancy: case report. Hum Reprod 19:1231–1234. doi:10.1093/humrep/deh211 PubMedCrossRef Bovicelli L, Ghi T, Pilu G, Farina A, Savelli L, Simonazzi G et al (2004) Prenatal diagnosis of a complete mole coexisting with a dichorionic twin pregnancy: case report. Hum Reprod 19:1231–1234. doi:10.​1093/​humrep/​deh211 PubMedCrossRef
29.
go back to reference Lambert-Messerlian G, Pinar H, Rubin LP, De Paepe ME, Tantravahi U, Steinhoff MM et al (2005) Second-trimester maternal serum markers in twin pregnancy with complete mole: report of 2 cases. Pediatr Dev Pathol 8:230–234. doi:10.1007/s10024-005-0121-9 PubMedCrossRef Lambert-Messerlian G, Pinar H, Rubin LP, De Paepe ME, Tantravahi U, Steinhoff MM et al (2005) Second-trimester maternal serum markers in twin pregnancy with complete mole: report of 2 cases. Pediatr Dev Pathol 8:230–234. doi:10.​1007/​s10024-005-0121-9 PubMedCrossRef
31.
go back to reference Klatt TE, Franciosi RA, Cruikshank DP (2006) Normal fetus with a twin presenting as both a complete hydatidiform mole and placenta previa. Obstet Gynecol 107:527–530PubMed Klatt TE, Franciosi RA, Cruikshank DP (2006) Normal fetus with a twin presenting as both a complete hydatidiform mole and placenta previa. Obstet Gynecol 107:527–530PubMed
32.
go back to reference Piura B, Rabinovich A, Hershkovitz R, Maor E, Mazor M (2008) Twin pregnancy with a complete hydatidiform mole and surviving co-existent fetus. Arch Gynecol Obstet. 2008 Feb 14. [Epub ahead of print] Piura B, Rabinovich A, Hershkovitz R, Maor E, Mazor M (2008) Twin pregnancy with a complete hydatidiform mole and surviving co-existent fetus. Arch Gynecol Obstet. 2008 Feb 14. [Epub ahead of print]
Metadata
Title
Twin pregnancy with a complete hydatidiform mole and co-existent live fetus: two case reports and review of the literature
Authors
Kenan Dolapcioglu
Arif Gungoren
Sibel Hakverdi
Ali Ulvi Hakverdi
Ertugrul Egilmez
Publication date
01-03-2009
Publisher
Springer-Verlag
Published in
Archives of Gynecology and Obstetrics / Issue 3/2009
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-008-0737-x

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