Top

Archives of Gynecology and Obstetrics

Published in:

01-07-2008 | Short Communication

Primary peritoneal serous papillary carcinoma: clinical and laboratory characteristics

Authors: C. Iavazzo, G. Vorgias, M. Katsoulis, N. Kalinoglou, V. Dertimas, T. Akrivos

Published in: Archives of Gynecology and Obstetrics | Issue 1/2008

Abstract

Background

Primary peritoneal papillary serous carcinoma (PPPSC) is an uncommon primary malignancy of the peritoneum. The aim of our study is to present the characteristics of such a rare entity through our case series.

Method

This is a retrospective study of nine cases of PPPSC who were treated between January 2002 and April 2007 in METAXA Memorial Cancer Hospital, Piraeus, Greece. Medical files and histopathological diagnosis of each patient were retrospectively studied.

Results

The median age of the patients was 63 years ranging from 44 up to 74 years. Clinically PPPSC presented with general abdominal discomfort in all of the patients. Three out of nine patients presented with constipation, 5/9 with distention, and 7/9 with ascites. All of the patients referred loss of appetite with weight gaining due to ascites. All the patients had pathological values of CA125 (over 35 U/ml) ranging from 125 up to 1,255 U/ml with median value 565 U/ml. Optimal debulking was possible in 3/9 of patients who were consequently treated with standard taxol-platin chemotherapy. Complete response was achieved in one woman. The median disease-free survival was 7 months and the median overall survival rate was 2.5 years.

Conclusion

PPPSC mimics ovarian papillary serous carcinoma regarding the clinical and laboratory characteristics but it has worse prognosis.

Eltabbakh G, Piver M, Natarajahn N, Mettlin C (1998) Epidemiologic differences between women with extraovarian primary peritoneal carcinoma and women with epithelial ovarian cancer. Obstet Gynecol 91:254–259. doi:10.1016/S0029-7844(97) 00650-9 PubMedCrossRef

Piek JM, Kenemans P, Verheijen RH (2004) Intraperitoneal serous adenocarcinoma: a critical appraisal of three hypotheses on its cause. Am J Obstet Gynecol 191:718–732. doi:10.1016/j.ajog.2004.02.067 PubMedCrossRef

Eltabbakh GH, Piver MS (1998) Extraovarian primary peritoneal carcinoma. Oncology 12:809–813

Eltabbakh GH, Piver MS, Natarajan N, Metlin CJ (1998) Epidemiologic differences between women with extraovarian primary peritoneal carcinoma and women with epithelial ovarian cancer. Obstet Gynecol 1:254–259. doi:10.1016/S0029-7844(97) 00650-9 CrossRef

Chou CS, Menzin AW, Leonard DGB, Rubin SC, Wheeler E (1999) Primary peritoneal carcinoma: a review of the literature. Obstet Gynecol Surv 54:323–335. doi:10.1097/00006254-199905000-00023 CrossRef

Swerdlow M (1959) Mesothelioma of the pelvic peritoneum resembling papillary cystadenocarcinoma of the ovary. Am J Obstet Gynecol 77:197–200PubMed

Fowler JM, Nieberg RK, Schooler TA, Berek JS (1994) Peritoneal adenocarcinoma (serous) of Mullerian type: a subgroup of women presenting with peritoneal carcinomatosis. Int J Gynecol Cancer 4:43–51. doi:10.1046/j.1525-1438.1994.04010043.x PubMedCrossRef

Bloss JD, Liao S-Y, Buller RE, Manetta A, Berman ML, McMeekin S et al (1993) Extraovarian peritoneal serous papillary carcinoma: a case-control retrospective comparison to papillary adenocarcinoma of the ovary. Gynecol Oncol 50:347–351. doi:10.1006/gyno.1993.1223 PubMedCrossRef

Jordan S et al (2007) Serous ovarian, fallopian tube, and primary peritoneal cancers: a comparative epidemiological analysis. Int J Cancer 122(7):1598–1603

10.

Barda G, Menczer J, Chetrit A, Lubin F, Beck D, Piura P et al (2004) Comparison between primary peritoneal and epithelial ovarian carcinoma. A population based study. Am J Obstet Gynecol 190:1039–1045. doi:10.1016/j.ajog.2003.09.073 PubMedCrossRef

11.

Fromm GL, Gershenson DM, Silva EG (1990) Papillary serous carcinoma of the peritoneum. Obstet Gynecol 75:75–89

12.

Hunter RW, Alexander ND, Soutter WP (1992) Meta-analysis of surgery in advanced ovarian carcinoma: is maximum cytoreductive surgery an independent determinant of prognosis? Am J Obstet Gynecol 166:504–511PubMed

13.

Menczer J (1992) Cytoreductive surgery in the treatment of advanced ovarian carcinoma. Some controversial aspects. Eur J Gynaecol Oncol 13:246–255PubMed

14.

Covens AL (2000) A critique of surgical cytoreduction in advanced ovarian cancer. Gynecol Oncol 78:269–274. doi:10.1006/gyno.2000.5926 PubMedCrossRef

15.

Dalrymple JC, Bannatyne P, Russell P et al (1989) Extraovarian peritoneal serous papillary carcinoma. A clinicopathologic study of 31 cases. Cancer 64:110–115. doi:10.1002/1097-0142(19890701)64:1≤110::AID-CNCR2820640120≥3.0.CO;2-5

16.

Killackey MA, Davis AR (1993) Papillary serous carcinoma of the peritoneal surface: matched-case comparison with papillary serous ovarian carcinoma. Gynecol Oncol 51:171–174. doi:10.1006/gyno.1993.1267 PubMedCrossRef

17.

Kowalski LD, Kanbour AI, Price FV et al (1997) A case-matched comparison of extraovarian versus primary ovarian adenocarcinoma. Cancer 79:1587–1594

18.

Ransom DT, Patel SR, Keeney GL, Malkasian GD, Edmonson JH (1990) Papillary serous carcinoma of the peritoneum. A review of 33 cases treated with platin-based chemotherapy. Cancer 66:1091–1094. doi:10.1002/1097-0142(19900915)66:6≤1091::AID-CNCR2820660602≥3.0.CO;2-F

19.

Piver MS, Eltabbakh GH, Hempling RE, Recio FO, Blumenson LE (1997) Two sequential studies for primary peritoneal carcinoma: induction with weekly cisplatin followed by either cisplatin-doxorubicincyclophosphamide or paclitaxel-cisplatin. Gynecol Oncol 67:141–146. doi:10.1006/gyno.1997.4843 PubMedCrossRef

20.

White CD (1993) Papillary intraperitoneal neoplasia resembling ovarian carcinoma after removal of benign ovaries. W V Med J 89:282–283PubMed

21.

Dalrymple JC, Bannatyne P, Russel P, Solomon HJ, Tattersall MHN, Atkinson K et al (1989) Extraovarian peritoneal carcinoma. A clinicopathological study of 31 cases. Cancer 64:110–115. doi:10.1002/1097-0142(19890701)64:1≤110::AID-CNCR2820640120≥3.0.CO;2-5

22.

Lele SB, Piver MS, Matharu J, Tsukadu Y (1988) Peritoneal papillary carcinoma. Gynecol Oncol 31:315–320. doi:10.1016/S0090-8258(88) 80010-6 PubMedCrossRef

23.

Wick MR, Mills SE, Dehner LP, Bollinger DJ, Fechner RE (1989) Serous papillary carcinomas arising from the peritoneum and ovaries. A clinicopathologic and immunohistochemical comparison. Int J Gynecol Pathol 8:179–188. doi:10.1097/00004347-198909000-00001 PubMed

24.

Ransom DT, Patel SR, Keeney GL, Malkasian GD (1990) Papillary serous carcinoma of the peritoneum: a review of 33 cases treated with platin based chemotherapy. Cancer 66:1091–1094. doi:10.1002/1097-0142(19900915)66:6≤1091::AID-CNCR2820660602≥3.0.CO;2-F

25.

Altaras NM, Aviram R, Cohen I, Cordoba M, Weiss E, Beyth Y (1991) Primary peritoneal papillary serous adenocarcinoma: clinical and management aspects. Gynecol Oncol 40:230–236. doi:10.1016/0090-8258(90) 90283-Q PubMedCrossRef

26.

Ben-Baruch G, Sivan E, Moran O, Rizel S, Menczer J, Seidman DS (1996) Primary peritoneal serous papillary carcinoma: a study of 25 cases and comparison with stage III–IV ovarian papillary serous carcinoma. Gynecol Oncol 60:393–396. doi:10.1006/gyno.1996.0060 PubMedCrossRef

27.

Halperin R, Zehavi S, Langer R, Hadas E, Bukovski I, Schneider D (2001) Primary peritoneal serous papillary carcinoma: a new epidemiologic trend? A matched case comparison with ovarian serous papillary cancer. Int J Gynecol Cancer 11:403–408. doi:10.1046/j.1525-1438.2001.01027.x PubMedCrossRef

28.

Mulhollan TJ, Silva EG, Tornos C, Guerrieri C, Fromm GL, Gershenson D (1994) Ovarian involvement by serous surface papillary carcinoma. Int J Gynecol Pathol 13:120–126. doi:10.1097/00004347-199404000-00003 PubMedCrossRef

Title: Primary peritoneal serous papillary carcinoma: clinical and laboratory characteristics
Authors: C. Iavazzo
G. Vorgias
M. Katsoulis
N. Kalinoglou
V. Dertimas
T. Akrivos
Publication date: 01-07-2008
Publisher: Springer-Verlag
Published in: Archives of Gynecology and Obstetrics / Issue 1/2008
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-008-0678-4

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Primary peritoneal serous papillary carcinoma: clinical and laboratory characteristics

Abstract

Background

Method

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Method

Results

Conclusion

Please log in to get access to this content

Other articles of this Issue 1/2008

Unusually large extraintestinal GIST presenting as an abdomino-pelvic tumor

Management of uterine giant myoma

Visceral leishmaniasis and pregnancy: analysis of cases reported in a central-western region of Brazil

Treatment options and pregnancy outcome in women with idiopathic recurrent miscarriage: a randomized placebo-controlled study

Erroneous statement regarding 2D ultrasound fetal urinary bladder volume measurement

Prepregnancy body mass index and adverse pregnancy outcomes