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Archives of Gynecology and Obstetrics

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01-11-2008 | Original Article

Comparison of multiple dose GnRH antagonist and minidose long agonist protocols in poor responders undergoing in vitro fertilization: a randomized controlled trial

Authors: Aybike Tazegül, Hüseyin Görkemli, Suna Özdemir, T. Murad Aktan

Published in: Archives of Gynecology and Obstetrics | Issue 5/2008

Abstract

Objective

To investigate the efficacy of gonadotropin releasing hormone antagonist (GnRH) in poor responders undergoing in vitro fertilization.

Study design

Ninety-six patients with poor ovarian response in previous treatment cycles were prospectively randomized into two groups. Forty-four patients were stimulated with GnRH antagonist multidose protocol and 45 patients received a standard long agonist protocol. Ovarian response was evaluated by transvaginal ultrasound and hormonal parameters. Cycle characteristics and treatment outcomes were statistically compared between groups.

Results

There was significantly reduced duration of stimulation and consumption of gonadotrophins in the antagonist group when compared to the agonist group. The estradiol concentrations on the day of human chorionic gonadotropin (hCG) injection, the number of oocytes retrieved, and the number of embryos transferred were similar for both groups. In the antagonist group, eight (18.1%) ongoing pregnancies were achieved and in the agonist group, ten (22.2%) clinical pregnancies were achieved but the difference was not statistically significant.

Conclusion

The present study was not powered to detect clinically relevant differences between two protocols in outcomes such as pregnancy rate, with confidence.

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Title: Comparison of multiple dose GnRH antagonist and minidose long agonist protocols in poor responders undergoing in vitro fertilization: a randomized controlled trial
Authors: Aybike Tazegül
Hüseyin Görkemli
Suna Özdemir
T. Murad Aktan
Publication date: 01-11-2008
Publisher: Springer-Verlag
Published in: Archives of Gynecology and Obstetrics / Issue 5/2008
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-008-0620-9

At a glance: The STEP trials

Springer Medicine

Comparison of multiple dose GnRH antagonist and minidose long agonist protocols in poor responders undergoing in vitro fertilization: a randomized controlled trial

Abstract

Objective

Study design

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Objective

Study design

Results

Conclusion

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