Skip to main content
Top
Published in: Archives of Gynecology and Obstetrics 4/2008

01-10-2008 | Original Article

Genital tuberculosis: a leading cause for infertility in women seeking assisted conception in North India

Authors: Neeta Singh, Gurunath Sumana, Suneeta Mittal

Published in: Archives of Gynecology and Obstetrics | Issue 4/2008

Login to get access

Abstract

Introduction

Genital tuberculosis is a major cause of tubal factor infertility in developing countries. Data regarding the current prevalence of tuberculosis in the infertile population are sparse.

Aims

To determine the incidence of tubal factor infertility in an infertile population seeking assisted reproduction and the prevalence of genital tuberculosis in this sub-group of patients and their symptomatology.

Materials and methods

A retrospective analysis of case records of infertile patients registered for in-vitro fertilization (IVF) between January 2007 and June 2007.

Results

Hundred and forty women with an indication for IVF were analyzed. Of these, 70 patients (50%) had tubal factor infertility. The prevalence of genital tuberculosis in tubal factor infertility was 34 out of 70 (48.5%). 82.8% of patients with tubal factor had history of prior treatment for tuberculosis. Menstrual abnormalities were seen in only 8 patients: hypomenorrhea (7) and secondary amenorrhea (1). A diagnostic hysteroscopy showed that 11 had uterine adhesions (18.9%) and 1 patient had pale endometrium. Twenty patients out of 70 cases (28.5%) showed evidence of extra genital tuberculosis.

Conclusion

Genital tuberculosis is the major causative factor for severe tubal disease requiring assisted reproduction in developing countries like India.
Literature
1.
go back to reference Jassawala MJ (2006) Genital tuberculosis—a diagnostic dilemma. J Obstet Gynaecol India 56(3):203–204 Jassawala MJ (2006) Genital tuberculosis—a diagnostic dilemma. J Obstet Gynaecol India 56(3):203–204
2.
go back to reference Schaefer G (1976) Female genital tuberculosis. Female genital tuberculosis. Clin Obstet Gynecol 19:223PubMedCrossRef Schaefer G (1976) Female genital tuberculosis. Female genital tuberculosis. Clin Obstet Gynecol 19:223PubMedCrossRef
3.
go back to reference Desai P, Hazra M (1993) Tubal infertility: reappraisal of etiology. J Obstet Gynaecol India 43:76–78 Desai P, Hazra M (1993) Tubal infertility: reappraisal of etiology. J Obstet Gynaecol India 43:76–78
4.
go back to reference Parikh FR, Nadkarni SG, Kamat SA, Naik N, Soonawala SB, Parikh RM (1997) Genital tuberculosis—a major factor causing infertility in Indian women. Fertil Steril 67:497–500PubMedCrossRef Parikh FR, Nadkarni SG, Kamat SA, Naik N, Soonawala SB, Parikh RM (1997) Genital tuberculosis—a major factor causing infertility in Indian women. Fertil Steril 67:497–500PubMedCrossRef
5.
go back to reference Tripathy SN, Tripathy SN (2002) Infertility and pregnancy outcome in female genital tuberculosis. Int J Gynecol Obstet 76:159–163CrossRef Tripathy SN, Tripathy SN (2002) Infertility and pregnancy outcome in female genital tuberculosis. Int J Gynecol Obstet 76:159–163CrossRef
6.
go back to reference Dam P, Shirazee HH, Goswami SK, Ghosh S, Ganesh A, Chaudhury K, Chakravarty B (2006) Role of latent genital tuberculosis in repeated IVF failure in the Indian clinical setting. Gynecol Obstet Invest 61:223–227PubMedCrossRef Dam P, Shirazee HH, Goswami SK, Ghosh S, Ganesh A, Chaudhury K, Chakravarty B (2006) Role of latent genital tuberculosis in repeated IVF failure in the Indian clinical setting. Gynecol Obstet Invest 61:223–227PubMedCrossRef
7.
go back to reference Khan SM (1985) Incidence of genital tuberculosis in infertile women. J Pak Med Assoc 35:280–281PubMed Khan SM (1985) Incidence of genital tuberculosis in infertile women. J Pak Med Assoc 35:280–281PubMed
8.
go back to reference Chattopadhyay SK, Sengupta BS, Edrees YB, Al-Meshari AA (1986) The pattern of female genital tuberculosis in Riyadh, Saudi Arabia. Br J Obstet Gynaecol 93(4):367–371PubMed Chattopadhyay SK, Sengupta BS, Edrees YB, Al-Meshari AA (1986) The pattern of female genital tuberculosis in Riyadh, Saudi Arabia. Br J Obstet Gynaecol 93(4):367–371PubMed
9.
go back to reference Oosthuizen AP, Wessels PH, Hefer JN (1990) Tuberculosis of the female genital tract in patients attending an infertility clinic. S Afr Med J 77:562–564PubMed Oosthuizen AP, Wessels PH, Hefer JN (1990) Tuberculosis of the female genital tract in patients attending an infertility clinic. S Afr Med J 77:562–564PubMed
10.
go back to reference De Vynck WE, Kruger TF, Joubert JJ, Scott F, Van der Merwe JP, Hulme VA, Swart Y (1990) Genital tuberculosis associated with female infertility in the western Cape. S Afr Med J 77:630–631PubMed De Vynck WE, Kruger TF, Joubert JJ, Scott F, Van der Merwe JP, Hulme VA, Swart Y (1990) Genital tuberculosis associated with female infertility in the western Cape. S Afr Med J 77:630–631PubMed
11.
go back to reference Marana R, Muzii L, Lucisano A, Ardito F, Muscatello P, Bilancioni E, Maniccia, Dell’Acqua S (1991) Incidence of genital tuberculosis in infertile patients submitted to diagnostic laparoscopy: recent experience in an Italian University Hospital. Int J Fertil 36(2):104–107PubMed Marana R, Muzii L, Lucisano A, Ardito F, Muscatello P, Bilancioni E, Maniccia, Dell’Acqua S (1991) Incidence of genital tuberculosis in infertile patients submitted to diagnostic laparoscopy: recent experience in an Italian University Hospital. Int J Fertil 36(2):104–107PubMed
12.
go back to reference Haider P, Jafarey SN (1992) A histopathological study of endometrial tuberculosis in infertility. J Pak Med Assoc 42(11):269–270PubMed Haider P, Jafarey SN (1992) A histopathological study of endometrial tuberculosis in infertility. J Pak Med Assoc 42(11):269–270PubMed
13.
go back to reference Margolis K, Wranz PAB, Kruger TF, Joubert JJ, Odendaal HJ (1992) Genital tuberculosis at Tygerberg Hospital—prevalence, clinical presentation and diagnosis. S Afr Med J 81:12–15PubMed Margolis K, Wranz PAB, Kruger TF, Joubert JJ, Odendaal HJ (1992) Genital tuberculosis at Tygerberg Hospital—prevalence, clinical presentation and diagnosis. S Afr Med J 81:12–15PubMed
14.
go back to reference Emembolu JO, Anyanwu DO, Ewa B (1993) Genital tuberculosis in infertile women in northern Nigeria. West Afr J Med 12:211–212PubMed Emembolu JO, Anyanwu DO, Ewa B (1993) Genital tuberculosis in infertile women in northern Nigeria. West Afr J Med 12:211–212PubMed
15.
go back to reference Gupta N, Sharma JB, Mittal S, Singh N, Misra R, Kukreja M (2007) Genital tuberculosis in Indian infertility patients. Int J Gynaecol Obstet 97(2):135–138PubMedCrossRef Gupta N, Sharma JB, Mittal S, Singh N, Misra R, Kukreja M (2007) Genital tuberculosis in Indian infertility patients. Int J Gynaecol Obstet 97(2):135–138PubMedCrossRef
Metadata
Title
Genital tuberculosis: a leading cause for infertility in women seeking assisted conception in North India
Authors
Neeta Singh
Gurunath Sumana
Suneeta Mittal
Publication date
01-10-2008
Publisher
Springer-Verlag
Published in
Archives of Gynecology and Obstetrics / Issue 4/2008
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-008-0590-y

Other articles of this Issue 4/2008

Archives of Gynecology and Obstetrics 4/2008 Go to the issue