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01-11-2007 | Original Article

Randomized comparison of second trimester pregnancy termination utilizing saline moistened or dry misoprostol

Authors: Bulent Yilmaz, Sefa Kelekci, Ibrahim Egemen Ertas, Murat Ozel, Necdet Sut, Leyla Mollamahmutoglu, Nuri Danisman

Published in: Archives of Gynecology and Obstetrics | Issue 5/2007

Abstract

Objective

The aim of this randomized prospective study was to compare efficacy and side effects of saline moistened misoprostol with dry misoprostol, administered 800 μg intravaginally every 6 h up to a maximum of 3 doses in 24 h for second trimester pregnancy termination.

Materials and methods

A total of 81 women seeking termination of second trimester pregnancy (55 fetal death, 17 fetal structural anomaly, 5 chromosomal abnormality, 4 other reasons) were randomly assigned to one of two treatment groups: (1) intravaginal non-moistened (dry) misoprostol in group A (n = 40) or (2) misoprostol moistened with 3 ml of saline in group B (n = 41).

Results

All of the patients in either group aborted within 48 h (100% success rate). Delivery was achieved in a median (interquartile range) of 13 (40) h with the group A protocol and 12 (36) h with the group B protocol (P = 0.652). Delivery with first dose, delivery within 12 h and delivery within 24 h were similar (P > 0.05) in group B (34.1, 87.5 and 60%, respectively) and group A (25, 82.9, 46.3, respectively). Both treatment regimens were tolerable and with similar side effects.

Conclusion

Misoprostol moistened with saline was not more effective than dry misoprostol for second trimester pregnancy termination.

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Title: Randomized comparison of second trimester pregnancy termination utilizing saline moistened or dry misoprostol
Authors: Bulent Yilmaz
Sefa Kelekci
Ibrahim Egemen Ertas
Murat Ozel
Necdet Sut
Leyla Mollamahmutoglu
Nuri Danisman
Publication date: 01-11-2007
Publisher: Springer-Verlag
Published in: Archives of Gynecology and Obstetrics / Issue 5/2007
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-007-0374-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Randomized comparison of second trimester pregnancy termination utilizing saline moistened or dry misoprostol

Abstract

Objective

Materials and methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Materials and methods

Results

Conclusion

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