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Archives of Dermatological Research

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Open Access 19-01-2023 | Lichen Sclerosus Et Atrophicus | ORIGINAL PAPER

Mid-term symptomatic relief after platelet-rich plasma infiltration in vulvar lichen sclerosus

Authors: Carola Medina Garrido, Alejandra Cano García, Lidia de la Cruz Cea, Ana B. Oreja Cuesta

Published in: Archives of Dermatological Research | Issue 6/2023

Abstract

Purpose

Vulvar lichen sclerosus (LS) is a chronic, progressive, autoimmune dermatologic condition that causes cutaneous changes accompanied by pruritus and pain. There remains a small population with vulvar LS refractory to topical corticosteroids. Injection of platelet-rich plasma (PRP) has been reported to have positive effects on tissue repair. The aim of this pilot study was to evaluate changes in symptom scores during and after PRP vulvar infiltration.

Methods

Three PRP infiltrations were administered to 28 female postmenopausal patients with biopsy-proved LS with unsatisfactory response to steroid therapy. Change in score according to the Clinical Scoring System for Vulvar Lichen Sclerosus (CSS) was measured on six occasions over the course of a year. We used growth curve modeling to measure change over the period of the study.

Results

Women in our study experienced a statistically significant improvement in auto-assessed symptoms of vulvar lichen sclerosus, and this improvement appears to be maintained throughout the monitoring year.

Conclusion

Platelet-rich plasma may have a role in symptom relief in certain cases of patients with LS that do not respond to first-line therapy.

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Title: Mid-term symptomatic relief after platelet-rich plasma infiltration in vulvar lichen sclerosus
Authors: Carola Medina Garrido
Alejandra Cano García
Lidia de la Cruz Cea
Ana B. Oreja Cuesta
Publication date: 19-01-2023
Publisher: Springer Berlin Heidelberg
Keyword: Lichen Sclerosus Et Atrophicus
Published in: Archives of Dermatological Research / Issue 6/2023
Print ISSN: 0340-3696
Electronic ISSN: 1432-069X
DOI: https://doi.org/10.1007/s00403-023-02529-1

At a glance: The STEP trials

Springer Medicine

Mid-term symptomatic relief after platelet-rich plasma infiltration in vulvar lichen sclerosus

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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