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Archives of Dermatological Research
Published in: Archives of Dermatological Research 10/2018

01-12-2018 | Concise Communication

Complex segregation analysis of facial melasma in Brazil: evidence for a genetic susceptibility with a dominant pattern of segregation

Authors: Nicole França Holmo, Geovana Brotto Ramos, Heloisa Salomão, Renata Iani Werneck, Marcelo Távora Mira, Luciane Donida Bartoli Miot, Hélio Amante Miot

Published in: Archives of Dermatological Research | Issue 10/2018

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Abstract

Despite high prevalence, the etiopathology of melasma is not fully understood. Nevertheless, many factors have been associated with the disease, including: sun exposure, sex steroids hormones, drugs, stress, and pregnancy. The high occurrence within familiars (40–60%) suggests a genetic predisposition to the disease. This study explored, through complex segregation analysis (CSA), the inheritance model that best fit the family segregation pattern of facial melasma when accounting for the main epidemiological risk factors. We evaluated 686 subjects from 67 families, and 260 (38%) of them had facial melasma. The CSA model, adjusted for age, skin phototype, sex, sun exposure at work, hormonal oral contraceptive, and pregnancy, evidenced a genetic component that was best fitted to a dominant pattern of segregation. Melasma results from an interaction between exposure factors (e.g. pregnancy, hormones, and sun exposure) over genetically predisposed individuals.
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Metadata
Title
Complex segregation analysis of facial melasma in Brazil: evidence for a genetic susceptibility with a dominant pattern of segregation
Authors
Nicole França Holmo
Geovana Brotto Ramos
Heloisa Salomão
Renata Iani Werneck
Marcelo Távora Mira
Luciane Donida Bartoli Miot
Hélio Amante Miot
Publication date
01-12-2018
Publisher
Springer Berlin Heidelberg
Published in
Archives of Dermatological Research / Issue 10/2018
Print ISSN: 0340-3696
Electronic ISSN: 1432-069X
DOI
https://doi.org/10.1007/s00403-018-1861-5

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