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01-01-2016 | Concise Communication

Correlation of IL36RN mutation with different clinical features of pustular psoriasis in Chinese patients

Authors: Ting-Shun Wang, Hsien-Yi Chiu, Jin-Bong Hong, Chih-Chieh Chan, Sung-Jan Lin, Tsen-Fang Tsai

Published in: Archives of Dermatological Research | Issue 1/2016

Abstract

Different studies have reported various values for the percentage of patients with IL36RN mutations, and it has also been reported that the sites of these mutations differ among different ethnicities. The current study was a cross-sectional study conducted to investigate the risk factors predicting IL36RN mutation in Chinese patients with different clinical features of pustular psoriasis. 57 Han Chinese patients, including 32 with generalized pustular psoriasis, 14 with palmoplantar pustulosis, 9 with plaque-type psoriasis with pustules, and 2 with erythrodermic psoriasis, were enrolled between March 2013 and July 2014. Blood samples were collected, genomic DNA was extracted from leukocytes, and polymerase chain reaction (PCR)-based Sanger sequencing was used to analyze the coding exons and flanking introns of the IL36RN gene. The patients with generalized pustular psoriasis exhibited the highest IL36RN mutation rate (75 %) among the aforementioned patient types, with the subgroup consisting of those patients who had features of acrodermatitis continua of Hallopeau exhibiting the highest c.115+6T>C mutation rate (93.8 %). In addition, early onset, ever generalized pustular psoriasis (more than two attacks), ever acrodermatitis continua of Hallopeau, inverse psoriasis, and a family history of pustular psoriasis were associated with IL36RN mutation. The c.115+6T>C mutation was the most common and the most important variant in all subtypes of pustular psoriasis with IL36RN mutations among our sample of Chinese patients.

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Title: Correlation of IL36RN mutation with different clinical features of pustular psoriasis in Chinese patients
Authors: Ting-Shun Wang
Hsien-Yi Chiu
Jin-Bong Hong
Chih-Chieh Chan
Sung-Jan Lin
Tsen-Fang Tsai
Publication date: 01-01-2016
Publisher: Springer Berlin Heidelberg
Published in: Archives of Dermatological Research / Issue 1/2016
Print ISSN: 0340-3696
Electronic ISSN: 1432-069X
DOI: https://doi.org/10.1007/s00403-015-1611-x

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Springer Medicine

Correlation of IL36RN mutation with different clinical features of pustular psoriasis in Chinese patients

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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