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Archives of Dermatological Research
Published in: Archives of Dermatological Research 5/2015

01-07-2015 | Concise Communication

Omentin-1 plasma levels and omentin-1 expression are decreased in psoriatic lesions of psoriasis patients

Authors: C. Zhang, K. J. Zhu, J. L. Liu, G. X. Xu, W. Liu, F. X. Jiang, H. F. Zheng, C. Quan

Published in: Archives of Dermatological Research | Issue 5/2015

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Abstract

Previous studies have suggested that psoriasis is associated with individuals who are overweight or obese. Omentin is a recently discovered adipokine that is involved in chronic inflammatory processes. This study evaluated the relationship between omentin and psoriasis, focusing on omentin-1 serum levels, skin expression of omentin-1, and omentin-1 gene polymorphism (rs2274907; Val109Asp). Levels of omentin-1 in serum samples from 44 patients with psoriasis and 38 healthy controls were analyzed by enzyme-linked immunosorbent assay. The expressions of omentin-1 were measured by immunohistochemistry in 3 psoriasis affected skins and 3 normal skins. The rs2274907 variant was typed using a SNaPshot assay in 354 cases and 214 controls. We found significantly lower serum levels of omentin-1 in psoriasis patients compared with healthy controls (p < 0.001) with an inverse correlation with the Psoriasis Area and Severity Index (p < 0.01). The comparison of genotype and allele distribution revealed no significant difference in genotype frequency between psoriasis patients and controls. Therefore, omentin-1 may have a role in the pathogenesis of psoriasis and might be a potential biological marker for psoriasis severity.
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Metadata
Title
Omentin-1 plasma levels and omentin-1 expression are decreased in psoriatic lesions of psoriasis patients
Authors
C. Zhang
K. J. Zhu
J. L. Liu
G. X. Xu
W. Liu
F. X. Jiang
H. F. Zheng
C. Quan
Publication date
01-07-2015
Publisher
Springer Berlin Heidelberg
Published in
Archives of Dermatological Research / Issue 5/2015
Print ISSN: 0340-3696
Electronic ISSN: 1432-069X
DOI
https://doi.org/10.1007/s00403-015-1549-z

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