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Published in:

01-07-2012 | Original Paper

Increased miRNA-146a and miRNA-155 expressions in oral lichen planus

Authors: Telma Cristina Arão, André Luiz Sena Guimarães, Alfredo Maurício Batista de Paula, Carolina Cavaliéri Gomes, Ricardo Santiago Gomez

Published in: Archives of Dermatological Research | Issue 5/2012

Abstract

Oral lichen planus (OLP) is a chronic inflammatory disease T helper 1 lymphocytes (Th1)-mediated. Interferon-gamma (IFN-γ) plays a central role in local immune response in this disease. MicroRNAs (miRNAs) are endogenously expressed non-coding RNAs that have important biological and pathological functions due to their potential mechanism regulating gene expression. Recently, some studies have demonstrated that miRNA-146a and miRNA-155 participate in immune response regulation, and are important in several chronic inflammatory and autoimmune diseases. The purpose of the present study was to investigate the expression of the miRNA-146a and miRNA-155 in 31 OLP lesions compared to normal oral mucosa and blood samples. Quantitative real-time polymerase chain reaction was used to analyze miRNA expressions. Our results showed increased expression of miRNA-146a and miRNA-155 in OLP lesions. In conclusion, these data highlight the possibility of miRNA-146a and miRNA-155 involvement in the regulation of the immune response in OLP.

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Title: Increased miRNA-146a and miRNA-155 expressions in oral lichen planus
Authors: Telma Cristina Arão
André Luiz Sena Guimarães
Alfredo Maurício Batista de Paula
Carolina Cavaliéri Gomes
Ricardo Santiago Gomez
Publication date: 01-07-2012
Publisher: Springer-Verlag
Published in: Archives of Dermatological Research / Issue 5/2012
Print ISSN: 0340-3696
Electronic ISSN: 1432-069X
DOI: https://doi.org/10.1007/s00403-011-1197-x

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Increased miRNA-146a and miRNA-155 expressions in oral lichen planus

Abstract

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Springer Medicine

Abstract

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