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Archives of Dermatological Research
Published in: Archives of Dermatological Research 10/2011

01-12-2011 | Original Paper

Inhibitory effects of TRPV1 blocker on UV-induced responses in the hairless mice

Authors: Young Mee Lee, So Min Kang, Se Rah Lee, Kyung Hwan Kong, Jeong Yoon Lee, Eun Ju Kim, Jin Ho Chung

Published in: Archives of Dermatological Research | Issue 10/2011

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Abstract

The transient receptor potential vanilloid 1 (TRPV1) channel can be activated by vanilloids, exposure to ultraviolet (UV) irradiation, heat, or protons, and conditions that occur during tissue injury. In the present study, we investigated whether or not TRPV1-specific blocker, 5′-iodoresiniferatoxin (I-RTX), can reduce UV-induced matrix metalloproteinases (MMPs), pro-inflammatory cytokines, cyclooxygenase (COX)-2, and p53 expression in the skin of hairless mice. Our results showed that I-RTX inhibited UV-induced skin thickening, as measured by a caliper, or in hematoxylin and eosin (H&E)-stained sections. UV-induced mRNA and protein expression of MMP-13, MMP-9, MMP-3, and MMP-2 was significantly reduced by I-RTX. We also observed the inhibitory effects of I-RTX on UV-induced mRNA expression of the pro-inflammatory cytokines, interleukin (IL)-1β, IL-2, IL-4, and tumor necrosis factor-α. UV-induced COX-2 and p53 protein expression was also significantly decreased by I-RTX. From the above results, we suggest that TRPV1-specific blocker, I-RTX, could prevent UV-induced skin responses, and provide new insight into development of effective therapeutic methods for photoaging.
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Metadata
Title
Inhibitory effects of TRPV1 blocker on UV-induced responses in the hairless mice
Authors
Young Mee Lee
So Min Kang
Se Rah Lee
Kyung Hwan Kong
Jeong Yoon Lee
Eun Ju Kim
Jin Ho Chung
Publication date
01-12-2011
Publisher
Springer-Verlag
Published in
Archives of Dermatological Research / Issue 10/2011
Print ISSN: 0340-3696
Electronic ISSN: 1432-069X
DOI
https://doi.org/10.1007/s00403-011-1153-9

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