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01-08-2010 | Original Paper

Restoration of peripheral blood T cell repertoire complexity during remission in advanced cutaneous T cell lymphoma

Authors: Kei-ichi Yamanaka, Robert C. Fuhlbrigge, Hitoshi Mizutani, Thomas S. Kupper

Published in: Archives of Dermatological Research | Issue 6/2010

Abstract

In advanced stages, cutaneous T cell lymphomas (CTCL) are associated with increased mortality from infections and also increased susceptibility to skin malignancies. In this study, we analyzed the complexity of the peripheral blood T cell repertoire with a sensitive b-variable (BV) complementarity-determining region 3 (CDR3) spectratyping analysis and flow cytometry in three-stage IV CTCL/Sezary syndrome patients who achieved complete clinical remission after therapy. The T cell repertoire of peripheral blood T cells before treatment was profoundly abnormal across multiple BV subfamilies. Following treatment, CDR3 spectratype patterns showed dramatic restoration of normal diversity and complexity. However, absolute CD4 counts across multiple BV families remained low for many months, even after identifiable circulating malignant T cell populations were eliminated. These data suggest that the diversity of the T cell repertoire can be recovered after successful treatment of even advanced CTCL.

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Title: Restoration of peripheral blood T cell repertoire complexity during remission in advanced cutaneous T cell lymphoma
Authors: Kei-ichi Yamanaka
Robert C. Fuhlbrigge
Hitoshi Mizutani
Thomas S. Kupper
Publication date: 01-08-2010
Publisher: Springer-Verlag
Published in: Archives of Dermatological Research / Issue 6/2010
Print ISSN: 0340-3696
Electronic ISSN: 1432-069X
DOI: https://doi.org/10.1007/s00403-009-1023-x

At a glance: The STEP trials

Springer Medicine

Restoration of peripheral blood T cell repertoire complexity during remission in advanced cutaneous T cell lymphoma

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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