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Archives of Orthopaedic and Trauma Surgery

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Open Access 01-10-2020 | Osteoporosis | Trauma Surgery

Local osteo-enhancement of osteoporotic vertebra with a triphasic bone implant material increases strength—a biomechanical study

Authors: Matthias Trost, Werner Schmoelz, Doris Wimmer, Romed Hörmann, Sönke Frey, Tobias Ludger Schulte

Published in: Archives of Orthopaedic and Trauma Surgery | Issue 10/2020

Abstract

Purpose

The aim of this study was to assess the biomechanical properties of intact vertebra augmented using a local osteo-enhancement procedure to inject a triphasic calcium sulfate/calcium phosphate implant material.

Methods

Twenty-one fresh frozen human cadaver vertebra (Th11–L2) were randomized into three groups: treatment, sham, and control (n = 7 each). Treatment included vertebral body access, saline lavage to displace soft tissue and marrow elements, and injection of the implant material to fill approximately 20% of the vertebral body by volume. The sham group included all treatment steps, but without injection of the implant material. The control group consisted of untreated intact osteoporotic vertebra. Load at failure and displacement at failure for each of the three groups were measured in axial compression loading.

Results

The mean failure load of treated vertebra (4118 N) was significantly higher than either control (2841 N) or sham (2186 N) vertebra (p < 0.05 for: treatment vs. control, treatment vs. sham). Treated vertebra (1.11 mm) showed a significantly higher mean displacement at failure than sham vertebra (0.80 mm) (p < 0.05 for: treatment vs. sham). In the control group, the mean displacement at failure was 0.99 mm.

Conclusions

This biomechanical study shows that a local osteo-enhancement procedure using a triphasic implant material significantly increases the load at failure and displacement at failure in cadaveric osteoporotic vertebra.

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Title: Local osteo-enhancement of osteoporotic vertebra with a triphasic bone implant material increases strength—a biomechanical study
Authors: Matthias Trost
Werner Schmoelz
Doris Wimmer
Romed Hörmann
Sönke Frey
Tobias Ludger Schulte
Publication date: 01-10-2020
Publisher: Springer Berlin Heidelberg
Keywords: Osteoporosis
Osteoporosis
Published in: Archives of Orthopaedic and Trauma Surgery / Issue 10/2020
Print ISSN: 0936-8051
Electronic ISSN: 1434-3916
DOI: https://doi.org/10.1007/s00402-020-03382-x

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Local osteo-enhancement of osteoporotic vertebra with a triphasic bone implant material increases strength—a biomechanical study

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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