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Archives of Orthopaedic and Trauma Surgery

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01-05-2013 | Knee Arthroplasty

Risk factors for deep infection after total knee arthroplasty: a meta-analysis

Authors: Jie Chen, Yunying Cui, Xin Li, Xiangwan Miao, Zhanpeng Wen, Yan Xue, Jing Tian

Published in: Archives of Orthopaedic and Trauma Surgery | Issue 5/2013

Abstract

Objective

Estimated the risk factors for postoperative infection after total knee arthroplasty (TKA) to prevent its occurrence.

Design

The meta-analysis collected twelve cohorts or case–control studies which included 548 infected persons in 57,223 general cases. Review Manager 5.0 was operated to assess the heterogeneity and to give an overall estimate of the association of factors with postoperative infection after TKA.

Results

The main factors distinctly associated with infection after TKA were BMI (BMI >30: OR = 2.53, 95 % CI 1.25, 5.13; BMI >40: OR = 4.00, 95 % CI 1.23, 12.98), diabetes mellitus (OR = 3.72, 95 % CI 2.30, 6.01), hypertension (OR = 2.53, 95 % CI 1.07, 5.99), steroid therapy (OR = 2.04, 95 % CI 1.11, 3.74), and rheumatoid arthritis (OR = 1.83; 95 % CI 1.42, 2.36). It had no sufficient evidences to reveal that gender could lead to infection after TKA. Osteoarthritis appeared to have a moderately protective effect. Statistical analysis revealed no correlation between urinary tract infection, fixation method, ASA, bilateral operation, age, transfusion, antibiotics, bone graft, and infection.

Conclusion

There were positive evidences for some certain factors which could be targeted for prevention of the onset of infection, but more studies are needed to define the association of some other controversial factors in infection, like osteoarthritis, gender and so on. The quality of studies also needs to be improved.

Available only for authorised users

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Title: Risk factors for deep infection after total knee arthroplasty: a meta-analysis
Authors: Jie Chen
Yunying Cui
Xin Li
Xiangwan Miao
Zhanpeng Wen
Yan Xue
Jing Tian
Publication date: 01-05-2013
Publisher: Springer-Verlag
Published in: Archives of Orthopaedic and Trauma Surgery / Issue 5/2013
Print ISSN: 0936-8051
Electronic ISSN: 1434-3916
DOI: https://doi.org/10.1007/s00402-013-1723-8

ACC 2024 Congress

Springer Medicine

Risk factors for deep infection after total knee arthroplasty: a meta-analysis

Abstract

Objective

Design

Results

Conclusion

ACC 2024 Congress

Springer Medicine

Abstract

Objective

Design

Results

Conclusion

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