Skip to main content
Top
Published in: Archives of Orthopaedic and Trauma Surgery 1/2013

01-01-2013 | Orthopaedic Surgery

Risk factors for nonunion in 337 displaced midshaft clavicular fractures treated with Knowles pin fixation

Authors: Chih-Lung Wu, Hui-Chin Chang, Ko-Hsiu Lu

Published in: Archives of Orthopaedic and Trauma Surgery | Issue 1/2013

Login to get access

Abstract

Background

Clavicular fractures account for nearly 10 % of all fractures, and the majority of those fractures involve the midshaft. Historically, these fractures were treated nonoperatively; however, recent data suggest an increased risk of nonunion and symptomatic malunion for displaced, comminuted midshaft clavicular fractures treated conservatively. Surgical intervention via plate osteosynthesis or intramedullary fixation with pins, nails, or screws has been shown to reduce, but not eliminate, this risk. Identification of risk factors predictive of nonunion would improve the overall management of displaced, comminuted midshaft clavicular fractures.

Methods

The medical records of 337 consecutive patients who underwent Knowles pin fixation and supplemental cerclage for the treatment of displaced, comminuted midshaft clavicular fractures between April 2007 and March 2009 were retrospectively reviewed. The records of the mechanism of injury, side of injury, Robinson fracture classification, presence of associated injuries, cerclage material, and patient-related variables, including diabetes mellitus, hypertension and smoking, were analyzed. Variables were assessed by univariate and multivariate analysis to identify those factors significantly associated with the development of fracture nonunion.

Results

A total of 19 nonunions occurred. Increasing age and use of wire for supplemental cerclage fixation were significantly associated with an increased risk for fracture nonunion (p < 0.001). Although suggested as predictors of nonunion in other studies, female gender and fracture severity were not significantly associated with nonunion.

Conclusions

Nonunion remains a significant complication in the treatment of displaced, comminuted midshaft clavicular fractures even with intramedullary fixation. Use of absorbable suture in place of wire for cerclage fixation and careful selection of treatment strategy in the elderly may reduce the risk for nonunion.
Literature
1.
go back to reference Kulshrestha V, Roy T, Audige L (2011) Operative versus nonoperative management of displaced midshaft clavicle fractures: a prospective cohort study. J Orthop Trauma 25(1):31–38PubMedCrossRef Kulshrestha V, Roy T, Audige L (2011) Operative versus nonoperative management of displaced midshaft clavicle fractures: a prospective cohort study. J Orthop Trauma 25(1):31–38PubMedCrossRef
2.
go back to reference Smekal V, Oberladstaetter J, Struve P, Krappinger D (2009) Shaft fractures of the clavicle: current concepts. Acta Orthop Trauma Surg 129(6):807–815CrossRef Smekal V, Oberladstaetter J, Struve P, Krappinger D (2009) Shaft fractures of the clavicle: current concepts. Acta Orthop Trauma Surg 129(6):807–815CrossRef
3.
go back to reference Hillen RJ, Burger BJ, Pöll RG, de Gast A, Robinson CM (2010) Malunion after midshaft clavicle fractures in adults. Acta Orthop 81(3):273–279PubMedCrossRef Hillen RJ, Burger BJ, Pöll RG, de Gast A, Robinson CM (2010) Malunion after midshaft clavicle fractures in adults. Acta Orthop 81(3):273–279PubMedCrossRef
4.
go back to reference Robinson CM (1998) Fractures of the clavicle in the adult. Epidemiology and classification. J Bone Jt Surg Br 80(3):476–484CrossRef Robinson CM (1998) Fractures of the clavicle in the adult. Epidemiology and classification. J Bone Jt Surg Br 80(3):476–484CrossRef
5.
go back to reference Nordqvist A, Petersson CJ, Redlund-Johnell I (1998) Mid-clavicle fractures in adults: end result study after conservative treatment. J Orthop Trauma 12(8):572–576PubMedCrossRef Nordqvist A, Petersson CJ, Redlund-Johnell I (1998) Mid-clavicle fractures in adults: end result study after conservative treatment. J Orthop Trauma 12(8):572–576PubMedCrossRef
6.
go back to reference Post M (1989) Current concepts in the treatment of fractures of the clavicle. Clin Orthop Relat Res 245:89–101PubMed Post M (1989) Current concepts in the treatment of fractures of the clavicle. Clin Orthop Relat Res 245:89–101PubMed
7.
go back to reference Smekal V, Deml C, Kamelger F, Dallapozza C, Krappinger D (2010) Corrective osteotomy in symptomatic midshaft clavicular malunion using elastic stable intramedullary nails. Arch Orthop Trauma Surg 130:681–685PubMedCrossRef Smekal V, Deml C, Kamelger F, Dallapozza C, Krappinger D (2010) Corrective osteotomy in symptomatic midshaft clavicular malunion using elastic stable intramedullary nails. Arch Orthop Trauma Surg 130:681–685PubMedCrossRef
8.
go back to reference Chu CM, Wang SJ, Lin LC (2002) Fixation of mid-third clavicular fractures with Knowles pins. Acta Orthop Scand 73(2):134–139PubMedCrossRef Chu CM, Wang SJ, Lin LC (2002) Fixation of mid-third clavicular fractures with Knowles pins. Acta Orthop Scand 73(2):134–139PubMedCrossRef
9.
go back to reference Zenni EJ Jr, Krieg JK, Rosen MJ (1981) Open reduction and internal fixation of clavicular fractures. J Bone Jt Surg Am 63(1):147–151 Zenni EJ Jr, Krieg JK, Rosen MJ (1981) Open reduction and internal fixation of clavicular fractures. J Bone Jt Surg Am 63(1):147–151
10.
go back to reference Robinson CM, Court-Brown CM, McQueen MM, Wakefield AE (2004) Estimating the risk of nonunion following nonoperative treatment of a clavicular fracture. J Bone Jt Surg Am 86-A(7):1359–1365 Robinson CM, Court-Brown CM, McQueen MM, Wakefield AE (2004) Estimating the risk of nonunion following nonoperative treatment of a clavicular fracture. J Bone Jt Surg Am 86-A(7):1359–1365
11.
go back to reference Brinker MR, Edwards TB, O’Connor DP (2005) Estimating the risk of nonunion following nonoperative treatment of a clavicular fracture (letter). J Bone Jt Surg Am 87:676–677 Brinker MR, Edwards TB, O’Connor DP (2005) Estimating the risk of nonunion following nonoperative treatment of a clavicular fracture (letter). J Bone Jt Surg Am 87:676–677
12.
go back to reference Altamimi SA, McKee MD (2008) Nonoperative treatment compared with plate fixation of displaced midshaft clavicular fractures. Surgical technique. J Bone Jt Surg Am 90(Suppl 2 Pt 1):1–8 Altamimi SA, McKee MD (2008) Nonoperative treatment compared with plate fixation of displaced midshaft clavicular fractures. Surgical technique. J Bone Jt Surg Am 90(Suppl 2 Pt 1):1–8
13.
go back to reference Lenza M, Belloti JC, Gomes Dos Santos JB, Matsumoto MH, Faloppa F (2009) Surgical interventions for treating acute fractures or non-union of the middle third of the clavicle. Cochrane Database Syst Rev (4):CD007428 Lenza M, Belloti JC, Gomes Dos Santos JB, Matsumoto MH, Faloppa F (2009) Surgical interventions for treating acute fractures or non-union of the middle third of the clavicle. Cochrane Database Syst Rev (4):CD007428
14.
go back to reference McKee MD (2010) Clavicle fractures in 2010: sling/swathe or open reduction and internal fixation? Orthop Clin North Am 41(2):225–231PubMedCrossRef McKee MD (2010) Clavicle fractures in 2010: sling/swathe or open reduction and internal fixation? Orthop Clin North Am 41(2):225–231PubMedCrossRef
15.
go back to reference Zlowodzki M, Zelle BA, Cole PA, Jeray K, McKee MD, Evidence-Based Orthopaedic Trauma Working Group (2005) Treatment of acute midshaft clavicle fractures: systematic review of 2144 fractures: on behalf of the Evidence-Based Orthopaedic Trauma Working Group. J Orthop Trauma 19(7):504–507PubMedCrossRef Zlowodzki M, Zelle BA, Cole PA, Jeray K, McKee MD, Evidence-Based Orthopaedic Trauma Working Group (2005) Treatment of acute midshaft clavicle fractures: systematic review of 2144 fractures: on behalf of the Evidence-Based Orthopaedic Trauma Working Group. J Orthop Trauma 19(7):504–507PubMedCrossRef
16.
go back to reference McKee RC, Whelan DB, Schemitsch EH, McKee MD (2012) Operative versus nonoperative care of displaced midshaft clavicular fractures: a meta-analysis of randomized clinical trials. J Bone Jt Surg Am 94(8):675–684CrossRef McKee RC, Whelan DB, Schemitsch EH, McKee MD (2012) Operative versus nonoperative care of displaced midshaft clavicular fractures: a meta-analysis of randomized clinical trials. J Bone Jt Surg Am 94(8):675–684CrossRef
17.
go back to reference Neviaser RJ, Neviaser JS, Neviaser TJ, Neviaser JS (1975) A simple technique for internal fixation of the clavicle. A long term evaluation. Clin Orthop Relat Res 109:103–107PubMedCrossRef Neviaser RJ, Neviaser JS, Neviaser TJ, Neviaser JS (1975) A simple technique for internal fixation of the clavicle. A long term evaluation. Clin Orthop Relat Res 109:103–107PubMedCrossRef
18.
go back to reference Lee YS, Lin CC, Huang CR, Chen CN, Liao WY (2007) Operative treatment of midclavicular fractures in 62 elderly patients: Knowles pin versus plate. Orthopedics 30(11):959–964PubMed Lee YS, Lin CC, Huang CR, Chen CN, Liao WY (2007) Operative treatment of midclavicular fractures in 62 elderly patients: Knowles pin versus plate. Orthopedics 30(11):959–964PubMed
19.
go back to reference Lee YS, Huang HL, Lo TY, Hsieh YF, Huang CR (2008) Surgical treatment of midclavicular fractures: a prospective comparison of Knowles pinning and plate fixation. Int Orthop 32(4):541–545PubMedCrossRef Lee YS, Huang HL, Lo TY, Hsieh YF, Huang CR (2008) Surgical treatment of midclavicular fractures: a prospective comparison of Knowles pinning and plate fixation. Int Orthop 32(4):541–545PubMedCrossRef
20.
21.
go back to reference McKee MD, Wild LM, Schemitsch EH (2004) Midshaft malunions of the clavicle. Surgical technique. J Bone Jt Surg Am 86-A(Suppl 1):37–43 McKee MD, Wild LM, Schemitsch EH (2004) Midshaft malunions of the clavicle. Surgical technique. J Bone Jt Surg Am 86-A(Suppl 1):37–43
22.
go back to reference Kim W, McKee MD (2008) Management of acute clavicle fractures. Orthop Clin North Am 39(4):491–505PubMedCrossRef Kim W, McKee MD (2008) Management of acute clavicle fractures. Orthop Clin North Am 39(4):491–505PubMedCrossRef
23.
go back to reference Liu HH, Chang CH, Chia WT, Chen CH, Tarng YW, Wong CY (2010) Comparison of plates versus intramedullary nails for fixation of displaced midshaft clavicular fractures. J Trauma 69(6):E82–E87PubMedCrossRef Liu HH, Chang CH, Chia WT, Chen CH, Tarng YW, Wong CY (2010) Comparison of plates versus intramedullary nails for fixation of displaced midshaft clavicular fractures. J Trauma 69(6):E82–E87PubMedCrossRef
24.
go back to reference Kitsis CK, Marino AJ, Krikler SJ, Birch R (2003) Late complications following clavicular fractures and their operative management. Injury 34(1):69–74PubMedCrossRef Kitsis CK, Marino AJ, Krikler SJ, Birch R (2003) Late complications following clavicular fractures and their operative management. Injury 34(1):69–74PubMedCrossRef
25.
go back to reference Pearson AM, Tosteson AN, Koval KJ, McKee MD, Cantu RV, Bell JE, Vicente M (2010) Is surgery for displaced, midshaft clavicle fractures in adults cost-effective? Results based on a mulitcenter randomized, controlled trial. J Orthop Trauma 24(7):426–433PubMedCrossRef Pearson AM, Tosteson AN, Koval KJ, McKee MD, Cantu RV, Bell JE, Vicente M (2010) Is surgery for displaced, midshaft clavicle fractures in adults cost-effective? Results based on a mulitcenter randomized, controlled trial. J Orthop Trauma 24(7):426–433PubMedCrossRef
26.
go back to reference Frigg A, Rillmann P, Perren T, Gerber M, Ryf C (2009) Intramedullary nailing of clavicular midshaft fractures with the titanium elastic nail: problems and complications. Am J Sports Med 37(2):352–359PubMedCrossRef Frigg A, Rillmann P, Perren T, Gerber M, Ryf C (2009) Intramedullary nailing of clavicular midshaft fractures with the titanium elastic nail: problems and complications. Am J Sports Med 37(2):352–359PubMedCrossRef
27.
go back to reference Basamania CJ (1999) Claviculoplasty and intramedullary fixation of malunited shortened clavicle fractures. J Should Elbow Surg 8:540 (abstract) Basamania CJ (1999) Claviculoplasty and intramedullary fixation of malunited shortened clavicle fractures. J Should Elbow Surg 8:540 (abstract)
28.
go back to reference Basamania CJ (2003) Treatment of clavicular fractures and malunions. In: Levine WN, Marra G, Bigliani LU (eds) Fractures of the shoulder girdle. Informa Healthcare, UK, pp 222–248 Basamania CJ (2003) Treatment of clavicular fractures and malunions. In: Levine WN, Marra G, Bigliani LU (eds) Fractures of the shoulder girdle. Informa Healthcare, UK, pp 222–248
29.
go back to reference Ferran NA, Hodgson P, Vannet N, Williams R, Evans RO (2010) Locked intramedullary fixation versus plating for displaced and shortened mid-shaft clavicle fractures: a randomized trial. J Should Elbow Surg 19(6):783–789CrossRef Ferran NA, Hodgson P, Vannet N, Williams R, Evans RO (2010) Locked intramedullary fixation versus plating for displaced and shortened mid-shaft clavicle fractures: a randomized trial. J Should Elbow Surg 19(6):783–789CrossRef
30.
go back to reference Parker MJ, Raghavan R, Gurusamy K (2007) Incidence of fracture-healing complications after femoral neck fractures. Clin Orthop Relat Res 458:175–179PubMed Parker MJ, Raghavan R, Gurusamy K (2007) Incidence of fracture-healing complications after femoral neck fractures. Clin Orthop Relat Res 458:175–179PubMed
31.
go back to reference Bidula JC, Boehm C, Powell K, Barsoum W, Nakamoto C, Mascha E, Muschler GF (2006) Osteogenic progenitors in bone marrow aspirates from smokers and nonsmokers. Clin Orthop Relat Res 442:252–259PubMedCrossRef Bidula JC, Boehm C, Powell K, Barsoum W, Nakamoto C, Mascha E, Muschler GF (2006) Osteogenic progenitors in bone marrow aspirates from smokers and nonsmokers. Clin Orthop Relat Res 442:252–259PubMedCrossRef
32.
go back to reference Chang IL, Lee TS, Ku MC (1994) Treatment of femoral fracture with nonunion. Kao-Hsiung i Hsueh Ko Hsueh Tsa Chih (Kaohsiung J Med Sci) 10(10):543–549 Chang IL, Lee TS, Ku MC (1994) Treatment of femoral fracture with nonunion. Kao-Hsiung i Hsueh Ko Hsueh Tsa Chih (Kaohsiung J Med Sci) 10(10):543–549
33.
go back to reference Solberg BD, Moon CN, Nissim AA, Wilson MT, Marqulies DR (2009) Treatment of chest wall implosion injuries without thoracotomy: technique and clinical outcomes. J Trauma 67(1):8–13PubMedCrossRef Solberg BD, Moon CN, Nissim AA, Wilson MT, Marqulies DR (2009) Treatment of chest wall implosion injuries without thoracotomy: technique and clinical outcomes. J Trauma 67(1):8–13PubMedCrossRef
34.
go back to reference Noumi TK, Yokoyama K, Ohtsuka H, Nakamura K, Itoman M (2005) Intramedullary nailing for open fractures of the femoral shaft: evaluation of contributing factors on deep infection and nonunion using multivariate analysis. Injury 36(9):1085–1093PubMedCrossRef Noumi TK, Yokoyama K, Ohtsuka H, Nakamura K, Itoman M (2005) Intramedullary nailing for open fractures of the femoral shaft: evaluation of contributing factors on deep infection and nonunion using multivariate analysis. Injury 36(9):1085–1093PubMedCrossRef
35.
go back to reference el Moumni M, Leenhouts PA, ten Duis HJ, Wendt KW (2009) The incidence of non-union following unreamed intramedullary nailing of femoral shaft fractures. Injury 40(2):205–208PubMedCrossRef el Moumni M, Leenhouts PA, ten Duis HJ, Wendt KW (2009) The incidence of non-union following unreamed intramedullary nailing of femoral shaft fractures. Injury 40(2):205–208PubMedCrossRef
36.
go back to reference Weiss JM, Graves S, Yang S, Mendelsohn E, Kay RM, Skaggs DL (2009) A new classification system predictive of complications in surgically treated pediatric humeral lateral condyle fractures. J Pediatr Orthop 29(6):602–605PubMedCrossRef Weiss JM, Graves S, Yang S, Mendelsohn E, Kay RM, Skaggs DL (2009) A new classification system predictive of complications in surgically treated pediatric humeral lateral condyle fractures. J Pediatr Orthop 29(6):602–605PubMedCrossRef
37.
go back to reference O’Neill BJ, Hirpara KM, O’Briain D, McGarr C, Kaar TK (2011) Clavicle fractures: a comparison of five classification systems and their relationship to treatment outcomes. Int Orthop 35(6):909–914PubMedCrossRef O’Neill BJ, Hirpara KM, O’Briain D, McGarr C, Kaar TK (2011) Clavicle fractures: a comparison of five classification systems and their relationship to treatment outcomes. Int Orthop 35(6):909–914PubMedCrossRef
38.
go back to reference Böhme JA, Bonk A, Bacher GO, Wilharm A, Hoffmann R, Josten C (2011) Current treatment concepts for mid-shaft fractures of the clavicle—results of a prospective multicentre study. Zeitschrift fur Orthopadie & Unfallchirurgie 149(1):68–76CrossRef Böhme JA, Bonk A, Bacher GO, Wilharm A, Hoffmann R, Josten C (2011) Current treatment concepts for mid-shaft fractures of the clavicle—results of a prospective multicentre study. Zeitschrift fur Orthopadie & Unfallchirurgie 149(1):68–76CrossRef
Metadata
Title
Risk factors for nonunion in 337 displaced midshaft clavicular fractures treated with Knowles pin fixation
Authors
Chih-Lung Wu
Hui-Chin Chang
Ko-Hsiu Lu
Publication date
01-01-2013
Publisher
Springer-Verlag
Published in
Archives of Orthopaedic and Trauma Surgery / Issue 1/2013
Print ISSN: 0936-8051
Electronic ISSN: 1434-3916
DOI
https://doi.org/10.1007/s00402-012-1631-3

Other articles of this Issue 1/2013

Archives of Orthopaedic and Trauma Surgery 1/2013 Go to the issue