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Published in: Archives of Orthopaedic and Trauma Surgery 11/2010

01-11-2010 | Basic Science

Crosslinked polyethylene in knee arthroplasty: a simulator study evaluating the positive influence on the tribocontact area in the fixed-bearing knee

Authors: S. Utzschneider, N. Harrasser, P. Sadoghi, P. Weber, C. Schröder, M. F. Pietschmann, V. Jansson

Published in: Archives of Orthopaedic and Trauma Surgery | Issue 11/2010

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Abstract

Background

Crosslinked polyethylene (XPE) was developed to reduce the wear rate in hip as well as knee arthroplasty. The crosslinking process reduces the mechanical properties of ultra-high-molecular-weight polyethylene (UHMWPE), particularly its fatigue strength. UHMWPE fatigue occurs more frequently in the knee than in the hip joint due to its changing tribocontact areas (TCAs) combined with high weight bearing. This is why XPE is still controversially discussed for use in total knee arthroplasty. Therefore, the potential advantage of using XPE in the knee was analysed in a simulator study with a focus on potential fatigue wear mechanisms.

Methods

Three different kinds of XPE and one conventional UHMWPE were tested over 5 million cycles in fixed-bearing knee designs. The TCAs were examined by replicas, and their extent was measured. The wear mechanism was analysed by scanning electron microscopy.

Results

The extent of the TCAs was less than 5% for all XPEs, whereas 35% for the conventional UHMWPE. Fatigue wear mechanisms were not observed.

Conclusion

The measured small extent of the TCAs as a predictor of a low wear rate without any fatigue wear mechanism shows a possible advantage for the use of XPE even in knee arthroplasty.
Literature
1.
go back to reference Affatato S, Leardini W, Rocchi M, Toni A, Viceconti M (2008) Investigation on wear of knee prostheses under fixed kinematic conditions. Artif Organs 32:13–18CrossRefPubMed Affatato S, Leardini W, Rocchi M, Toni A, Viceconti M (2008) Investigation on wear of knee prostheses under fixed kinematic conditions. Artif Organs 32:13–18CrossRefPubMed
2.
go back to reference Asano T, Akagi M, Clarke IC, Masuda S, Ishii T, Nakamura T (2007) Dose effects of cross-linking polyethylene for total knee arthroplasty on wear performance and mechanical properties. J Biomed Mater Res B Appl Biomater 83:615–622PubMed Asano T, Akagi M, Clarke IC, Masuda S, Ishii T, Nakamura T (2007) Dose effects of cross-linking polyethylene for total knee arthroplasty on wear performance and mechanical properties. J Biomed Mater Res B Appl Biomater 83:615–622PubMed
3.
go back to reference Bartel DL, Bicknell VL, Wright TM (1986) The effect of conformity, thickness, and material on stresses in ultra-high molecular weight components for total joint replacement. J Bone Joint Surg Am 68:1041–1051PubMed Bartel DL, Bicknell VL, Wright TM (1986) The effect of conformity, thickness, and material on stresses in ultra-high molecular weight components for total joint replacement. J Bone Joint Surg Am 68:1041–1051PubMed
4.
go back to reference Catelas I, Huk OL, Petit A, Zukor DJ, Marchand R, Yahia L (1998) Flow cytometric analysis of macrophage response to ceramic and polyethylene particles: effects of size, concentration, and composition. J Biomed Mater Res 41:600–607CrossRefPubMed Catelas I, Huk OL, Petit A, Zukor DJ, Marchand R, Yahia L (1998) Flow cytometric analysis of macrophage response to ceramic and polyethylene particles: effects of size, concentration, and composition. J Biomed Mater Res 41:600–607CrossRefPubMed
5.
go back to reference Digas G, Karrholm J, Thanner J, Malchau H, Herberts P (2003) Highly crosslinked polyethylene in cemented THA: randomized study of 61 hips. Clin Orthop Relat Res 417:126–138 Digas G, Karrholm J, Thanner J, Malchau H, Herberts P (2003) Highly crosslinked polyethylene in cemented THA: randomized study of 61 hips. Clin Orthop Relat Res 417:126–138
6.
go back to reference Estok DM, Bragdon CR, Plank GR, Huang A, Muratoglu OK, Harris WH (2005) The measurement of creep in ultrahigh molecular weight polyethylene: a comparison of conventional versus highly cross-linked polyethylene. J Arthroplasty 20:239–243CrossRefPubMed Estok DM, Bragdon CR, Plank GR, Huang A, Muratoglu OK, Harris WH (2005) The measurement of creep in ultrahigh molecular weight polyethylene: a comparison of conventional versus highly cross-linked polyethylene. J Arthroplasty 20:239–243CrossRefPubMed
7.
go back to reference Fisher J, McEwen H M, Tipper JL, Galvin AL, Ingram J, Kamali A, Stone MH, Ingham E (2004) Wear, debris, and biologic activity of cross-linked polyethylene in the knee: benefits and potential concerns. Clin Orthop Relat Res 428:114–119 Fisher J, McEwen H M, Tipper JL, Galvin AL, Ingram J, Kamali A, Stone MH, Ingham E (2004) Wear, debris, and biologic activity of cross-linked polyethylene in the knee: benefits and potential concerns. Clin Orthop Relat Res 428:114–119
8.
go back to reference Gencur SJ, Rimnac CM, Kurtz SM (2003) Failure micromechanisms during uniaxial tensile fracture of conventional and highly crosslinked ultra-high molecular weight polyethylenes used in total joint replacements. Biomaterials 24:3947–3954CrossRefPubMed Gencur SJ, Rimnac CM, Kurtz SM (2003) Failure micromechanisms during uniaxial tensile fracture of conventional and highly crosslinked ultra-high molecular weight polyethylenes used in total joint replacements. Biomaterials 24:3947–3954CrossRefPubMed
9.
go back to reference Green TR, Fisher J, Matthews JB, Stone MH, Ingham E (2000) Effect of size and dose on bone resorption activity of macrophages by in vitro clinically relevant ultra high molecular weight polyethylene particles. J Biomed Mater Res 53:490–497CrossRefPubMed Green TR, Fisher J, Matthews JB, Stone MH, Ingham E (2000) Effect of size and dose on bone resorption activity of macrophages by in vitro clinically relevant ultra high molecular weight polyethylene particles. J Biomed Mater Res 53:490–497CrossRefPubMed
10.
go back to reference Green TR, Fisher J, Stone M, Wroblewski BM, Ingham E (1998) Polyethylene particles of a ‘critical size’ are necessary for the induction of cytokines by macrophages in vitro. Biomaterials 19:2297–2302CrossRefPubMed Green TR, Fisher J, Stone M, Wroblewski BM, Ingham E (1998) Polyethylene particles of a ‘critical size’ are necessary for the induction of cytokines by macrophages in vitro. Biomaterials 19:2297–2302CrossRefPubMed
11.
go back to reference Heisel C, Silva M, Schmalzried TP (2005) In vivo wear of bilateral total hip replacements: conventional versus crosslinked polyethylene. Arch Orthop Trauma Surg 125:555–557CrossRefPubMed Heisel C, Silva M, Schmalzried TP (2005) In vivo wear of bilateral total hip replacements: conventional versus crosslinked polyethylene. Arch Orthop Trauma Surg 125:555–557CrossRefPubMed
12.
go back to reference Ingham E, Fisher J (2000) Biological reactions to wear debris in total joint replacement. Proc Inst Mech Eng H 214:21–37PubMed Ingham E, Fisher J (2000) Biological reactions to wear debris in total joint replacement. Proc Inst Mech Eng H 214:21–37PubMed
13.
go back to reference International Standard ISO/FDIS 14243 (2002) Implants for surgery—wear of total knee-joint-prosthesis—Part 1: Loading and displacement parameters for wear-testing machines with load control and corresponding environmental conditions for tests International Standard ISO/FDIS 14243 (2002) Implants for surgery—wear of total knee-joint-prosthesis—Part 1: Loading and displacement parameters for wear-testing machines with load control and corresponding environmental conditions for tests
14.
go back to reference Kurtz SM, Muratoglu OK, Evans M, Edidin AA (1999) Advances in the processing, sterilization, and crosslinking of ultra-high molecular weight polyethylene for total joint arthroplasty. Biomaterials 20:1659–1688CrossRefPubMed Kurtz SM, Muratoglu OK, Evans M, Edidin AA (1999) Advances in the processing, sterilization, and crosslinking of ultra-high molecular weight polyethylene for total joint arthroplasty. Biomaterials 20:1659–1688CrossRefPubMed
15.
go back to reference Loer I, Plitz W (2003) Tibial malalignment of mobile-bearing prostheses—a simulator study. Orthopade 32:296–304CrossRefPubMed Loer I, Plitz W (2003) Tibial malalignment of mobile-bearing prostheses—a simulator study. Orthopade 32:296–304CrossRefPubMed
16.
go back to reference McEwen HM, Fisher J, Goldsmith AA, Auger DD, Hardaker C, Stone MH (2001) Wear of fixed bearing and rotating platform mobile bearing knees subjected to high levels of internal and external tibial rotation. J Mater Sci Mater Med 12:1049–1052CrossRefPubMed McEwen HM, Fisher J, Goldsmith AA, Auger DD, Hardaker C, Stone MH (2001) Wear of fixed bearing and rotating platform mobile bearing knees subjected to high levels of internal and external tibial rotation. J Mater Sci Mater Med 12:1049–1052CrossRefPubMed
17.
go back to reference Muratoglu OK, Bragdon CR, Jasty M, O’Connor DO, Von Knoch RS, Harris WH (2004) Knee-simulator testing of conventional and cross-linked polyethylene tibial inserts. J Arthroplasty 19:887–897CrossRefPubMed Muratoglu OK, Bragdon CR, Jasty M, O’Connor DO, Von Knoch RS, Harris WH (2004) Knee-simulator testing of conventional and cross-linked polyethylene tibial inserts. J Arthroplasty 19:887–897CrossRefPubMed
18.
go back to reference Muratoglu OK, Bragdon CR, O’Connor DO, Jasty M, Harris WH (2001) A novel method of cross-linking ultra-high-molecular-weight polyethylene to improve wear, reduce oxidation, retain mechanical properties. Recipient of the 1999 HAP Paul Award. J Arthroplasty 16:149–160CrossRefPubMed Muratoglu OK, Bragdon CR, O’Connor DO, Jasty M, Harris WH (2001) A novel method of cross-linking ultra-high-molecular-weight polyethylene to improve wear, reduce oxidation, retain mechanical properties. Recipient of the 1999 HAP Paul Award. J Arthroplasty 16:149–160CrossRefPubMed
19.
go back to reference Muratoglu OK, Bragdon CR, O’Connor DO, Jasty M, Harris WH, Gul R, McGarry F (1999) Unified wear model for highly crosslinked ultra-high molecular weight polyethylenes (UHMWPE). Biomaterials 20:1463–1470CrossRefPubMed Muratoglu OK, Bragdon CR, O’Connor DO, Jasty M, Harris WH, Gul R, McGarry F (1999) Unified wear model for highly crosslinked ultra-high molecular weight polyethylenes (UHMWPE). Biomaterials 20:1463–1470CrossRefPubMed
20.
go back to reference Muratoglu OK, Perinchief RS, Bragdon CR, O’Connor DO, Konrad R, Harris WH (2003) Metrology to quantify wear and creep of polyethylene tibial knee inserts. Clin Orthop Relat Res 410:155–164 Muratoglu OK, Perinchief RS, Bragdon CR, O’Connor DO, Konrad R, Harris WH (2003) Metrology to quantify wear and creep of polyethylene tibial knee inserts. Clin Orthop Relat Res 410:155–164
21.
go back to reference Purdue PE, Koulouvaris P, Potter HG, Nestor BJ, Sculco TP (2007) The cellular and molecular biology of periprosthetic osteolysis. Clin Orthop Relat Res 454:251–261CrossRefPubMed Purdue PE, Koulouvaris P, Potter HG, Nestor BJ, Sculco TP (2007) The cellular and molecular biology of periprosthetic osteolysis. Clin Orthop Relat Res 454:251–261CrossRefPubMed
22.
go back to reference Ries MD (2005) Highly cross-linked polyethylene: the debate is over—in opposition. J Arthroplasty 20:59–62PubMed Ries MD (2005) Highly cross-linked polyethylene: the debate is over—in opposition. J Arthroplasty 20:59–62PubMed
23.
go back to reference Shanbhag AS, Jacobs JJ, Black J, Galante JO, Glant TT (1994) Macrophage/particle interactions: effect of size, composition and surface area. J Biomed Mater Res 28:81–90CrossRefPubMed Shanbhag AS, Jacobs JJ, Black J, Galante JO, Glant TT (1994) Macrophage/particle interactions: effect of size, composition and surface area. J Biomed Mater Res 28:81–90CrossRefPubMed
24.
go back to reference Shen FW, McKellop H (2005) Surface-gradient cross-linked polyethylene acetabular cups: oxidation resistance and wear against smooth and rough femoral balls. Clin Orthop Relat Res 430:80–88 Shen FW, McKellop H (2005) Surface-gradient cross-linked polyethylene acetabular cups: oxidation resistance and wear against smooth and rough femoral balls. Clin Orthop Relat Res 430:80–88
25.
go back to reference Tamura J, Clarke IC, Kawanabe K, Akagi M, Good VD, Williams PA, Masaoka T, Schroeder D, Oonishi H (2002) Micro-wear patterns on UHMWPE tibial inserts in total knee joint simulation. J Biomed Mater Res 61:218–225CrossRefPubMed Tamura J, Clarke IC, Kawanabe K, Akagi M, Good VD, Williams PA, Masaoka T, Schroeder D, Oonishi H (2002) Micro-wear patterns on UHMWPE tibial inserts in total knee joint simulation. J Biomed Mater Res 61:218–225CrossRefPubMed
26.
go back to reference Utzschneider S, Harrasser N, Schroeder C, Mazoochian F, Jansson V (2009) Wear of contemporary total knee replacements—a knee simulator study of six current designs. Clin Biomech 24(7):583–588 Utzschneider S, Harrasser N, Schroeder C, Mazoochian F, Jansson V (2009) Wear of contemporary total knee replacements—a knee simulator study of six current designs. Clin Biomech 24(7):583–588
27.
go back to reference Wooley PH, Morren R, Andary J, Sud S, Yang SY, Mayton L, Markel D, Sieving A, Nasser S (2002) Inflammatory responses to orthopaedic biomaterials in the murine air pouch. Biomaterials 23:517–526CrossRefPubMed Wooley PH, Morren R, Andary J, Sud S, Yang SY, Mayton L, Markel D, Sieving A, Nasser S (2002) Inflammatory responses to orthopaedic biomaterials in the murine air pouch. Biomaterials 23:517–526CrossRefPubMed
28.
go back to reference Yamamoto K, Clarke IC, Masaoka T, Oonishi H, Williams PA, Good VD, Imakiire A (2001) Microwear phenomena of ultrahigh molecular weight polyethylene cups and debris morphology related to gamma radiation dose in simulator study. J Biomed Mater Res 56:65–73CrossRefPubMed Yamamoto K, Clarke IC, Masaoka T, Oonishi H, Williams PA, Good VD, Imakiire A (2001) Microwear phenomena of ultrahigh molecular weight polyethylene cups and debris morphology related to gamma radiation dose in simulator study. J Biomed Mater Res 56:65–73CrossRefPubMed
29.
go back to reference Young TH, Lee YM, Cheng CK, Chen LY, Huang CH (1999) Analysis of ultrahigh molecular weight polyethylene failure in artificial knee joints: thermal effect on long-term performance. J Biomed Mater Res 48:159–164CrossRefPubMed Young TH, Lee YM, Cheng CK, Chen LY, Huang CH (1999) Analysis of ultrahigh molecular weight polyethylene failure in artificial knee joints: thermal effect on long-term performance. J Biomed Mater Res 48:159–164CrossRefPubMed
30.
go back to reference Zysk SP, Gebhard H, Plitz W, Buchhorn GH, Sprecher CM, Jansson V, Messmer K, Veihelmann A (2004) Influence of orthopedic particulate biomaterials on inflammation and synovial microcirculation in the murine knee joint. J Biomed Mater Res B Appl Biomater 71:108–115CrossRefPubMed Zysk SP, Gebhard H, Plitz W, Buchhorn GH, Sprecher CM, Jansson V, Messmer K, Veihelmann A (2004) Influence of orthopedic particulate biomaterials on inflammation and synovial microcirculation in the murine knee joint. J Biomed Mater Res B Appl Biomater 71:108–115CrossRefPubMed
31.
go back to reference Zysk SP, Gebhard HH, Kalteis T, Schmitt-Sody M, Jansson V, Messmer K, Veihelmann A (2005) Particles of all sizes provoke inflammatory responses in vivo. Clin Orthop Relat Res 433:258–264 Zysk SP, Gebhard HH, Kalteis T, Schmitt-Sody M, Jansson V, Messmer K, Veihelmann A (2005) Particles of all sizes provoke inflammatory responses in vivo. Clin Orthop Relat Res 433:258–264
32.
go back to reference Zysk SP, Gebhard HH, Pellengahr C, Refior HJ, Plitz W, Messmer K, Veihelmann A (2003) Inflammatory responses to wear particles in vivo: a novel model in the murine knee joint. Orthopade 32:305–311CrossRefPubMed Zysk SP, Gebhard HH, Pellengahr C, Refior HJ, Plitz W, Messmer K, Veihelmann A (2003) Inflammatory responses to wear particles in vivo: a novel model in the murine knee joint. Orthopade 32:305–311CrossRefPubMed
Metadata
Title
Crosslinked polyethylene in knee arthroplasty: a simulator study evaluating the positive influence on the tribocontact area in the fixed-bearing knee
Authors
S. Utzschneider
N. Harrasser
P. Sadoghi
P. Weber
C. Schröder
M. F. Pietschmann
V. Jansson
Publication date
01-11-2010
Publisher
Springer-Verlag
Published in
Archives of Orthopaedic and Trauma Surgery / Issue 11/2010
Print ISSN: 0936-8051
Electronic ISSN: 1434-3916
DOI
https://doi.org/10.1007/s00402-010-1159-3

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