Skip to main content
Top
Published in: Archives of Orthopaedic and Trauma Surgery 5/2004

01-06-2004 | Original Article

Morbidity and mortality after hip fracture: the impact of operative delay

Authors: Michael Gdalevich, Dani Cohen, Dina Yosef, Chanan Tauber

Published in: Archives of Orthopaedic and Trauma Surgery | Issue 5/2004

Login to get access

Abstract

Introduction

The relationship between the timing of surgery after hip fracture and the subsequent survival of the patient has been studied extensively, yet still remains a controversy. This study aims to assess the impact of operative delay on the 1-year survival of patients and on the rate of complications during the postoperative hospital stay.

Materials and methods

Medical and demographic data were extracted from the hospital records of 651 consecutive hip fracture patients over 60 years old. Information on mortality was obtained by cross-linkage with the Department of Interior population files. The multivariate survival analysis model was utilized to assess the association between the time from fracture incident to surgery and the outcome (1-year survival and postoperative complications).

Results

The hazard ratio (HR) of 1-year mortality for postponing surgery beyond 48 h was 1.63 (95%CI 1.11–2.40), as derived by the Cox proportional hazards model. Other variables found to be independently associated with decreased survival are: male gender (HR=1.54), mental deterioration (HR=2.94), postoperative mobility (HR=2.45), and severity of pre-existing diseases (HR=1.96). Occurrence of general complications during the postoperative hospital stay was a significant predictor of decreased 1-year survival (HR=1.83).

Conclusion

These findings suggest that early (within 48 h) surgical treatment of hip fractures is associated with improved 1-year survival.
Literature
1.
go back to reference Baker SP, Harvey AH (1985) Falls in the elderly. Clin Geriatr Med 1:501–512PubMed Baker SP, Harvey AH (1985) Falls in the elderly. Clin Geriatr Med 1:501–512PubMed
2.
go back to reference Beloosesky Y, Hendel D, Hershkovitz A, Skribnic G, Grinblat J (2001) Outcome of medically unstable elderly patients admitted to a geriatric ward after hip fracture. Aging 13:78–84PubMed Beloosesky Y, Hendel D, Hershkovitz A, Skribnic G, Grinblat J (2001) Outcome of medically unstable elderly patients admitted to a geriatric ward after hip fracture. Aging 13:78–84PubMed
3.
go back to reference Bhattacharyya T, Iorio R, Healy WL (2002) Rate of and risk factors for acute inpatient mortality after orthopaedic surgery. J Bone Joint Surg Am 84:562–572 Bhattacharyya T, Iorio R, Healy WL (2002) Rate of and risk factors for acute inpatient mortality after orthopaedic surgery. J Bone Joint Surg Am 84:562–572
4.
go back to reference Bredahl C, Nyholm B, Hindsholm KB, Mortensen JS, Olesen AS (1992) Mortality after hip fracture: results of operation within 12 h of admission. Injury 23:83–86PubMed Bredahl C, Nyholm B, Hindsholm KB, Mortensen JS, Olesen AS (1992) Mortality after hip fracture: results of operation within 12 h of admission. Injury 23:83–86PubMed
5.
go back to reference Cooper C (1997) The crippling consequences of fractures and their impact on quality of life. Am J Med 103:12S-17S Cooper C (1997) The crippling consequences of fractures and their impact on quality of life. Am J Med 103:12S-17S
6.
go back to reference Cooper C, Atkinson EJ, Jacobsen SJ, O’Fallon WM, Melton-LJ 3d (1993) Population-based study of survival after osteoporotic fractures. Am J Epidemiol 137:1001–1005PubMed Cooper C, Atkinson EJ, Jacobsen SJ, O’Fallon WM, Melton-LJ 3d (1993) Population-based study of survival after osteoporotic fractures. Am J Epidemiol 137:1001–1005PubMed
7.
go back to reference Cumming RG, Nevitt MC, Cummings SR (1997) Epidemiology of hip fractures. Epidemiol Rev 19:244–257PubMed Cumming RG, Nevitt MC, Cummings SR (1997) Epidemiology of hip fractures. Epidemiol Rev 19:244–257PubMed
8.
go back to reference Dahl E (1980) Mortality and life expectancy after hip fractures. Acta Orthop Scand 51:163–170PubMed Dahl E (1980) Mortality and life expectancy after hip fractures. Acta Orthop Scand 51:163–170PubMed
9.
go back to reference Davidson TI, Bodey WN (1986) Factors influencing survival following fractures of the upper end of the femur. Injury 17:12–14PubMed Davidson TI, Bodey WN (1986) Factors influencing survival following fractures of the upper end of the femur. Injury 17:12–14PubMed
10.
go back to reference Davis FM, Woolner DF, Frampton C et al (1987) Prospective, multi-center trial of mortality following general or spinal anaesthesia for hip fracture in the elderly. Br J Anaesth 59:1080–1088PubMed Davis FM, Woolner DF, Frampton C et al (1987) Prospective, multi-center trial of mortality following general or spinal anaesthesia for hip fracture in the elderly. Br J Anaesth 59:1080–1088PubMed
11.
go back to reference Davis TR, Sher JL, Porter BB, Checketts RG (1988) The timing of surgery for intertrochanteric femoral fractures. Injury 19:244–246PubMed Davis TR, Sher JL, Porter BB, Checketts RG (1988) The timing of surgery for intertrochanteric femoral fractures. Injury 19:244–246PubMed
12.
go back to reference Dennison E, Cooper C (2000) Epidemiology of osteoporotic fractures. Horm Res 54 [Suppl 1]:58–63 Dennison E, Cooper C (2000) Epidemiology of osteoporotic fractures. Horm Res 54 [Suppl 1]:58–63
13.
go back to reference Dolk T (1990) Operation in hip fracture patients—analysis of the time factor. Injury 21:369–372PubMed Dolk T (1990) Operation in hip fracture patients—analysis of the time factor. Injury 21:369–372PubMed
14.
go back to reference Dripps RD, Lamont A, Eckenhoff JE (1961) The role of anesthesia in surgical mortality. JAMA 178:261–266 Dripps RD, Lamont A, Eckenhoff JE (1961) The role of anesthesia in surgical mortality. JAMA 178:261–266
15.
go back to reference Eiskjaer S, Ostgard SE (1991) Risk factors influencing mortality after bipolar hemiarthroplasty in the treatment of fracture of the femoral neck. Clin Orthop 270:295–300PubMed Eiskjaer S, Ostgard SE (1991) Risk factors influencing mortality after bipolar hemiarthroplasty in the treatment of fracture of the femoral neck. Clin Orthop 270:295–300PubMed
16.
go back to reference Eshkenazi AU, Lokiec F, Giveon U, Horoszowski H, Malkin C, Weigl K (1991) Fractures of the proximal femur. Harefuah 121:79–83PubMed Eshkenazi AU, Lokiec F, Giveon U, Horoszowski H, Malkin C, Weigl K (1991) Fractures of the proximal femur. Harefuah 121:79–83PubMed
17.
go back to reference Forster MC, Calthorpe D (2000) Mortality following surgery for proximal femoral fractures in centenarians. Injury 31:537–539CrossRefPubMed Forster MC, Calthorpe D (2000) Mortality following surgery for proximal femoral fractures in centenarians. Injury 31:537–539CrossRefPubMed
18.
go back to reference Fox HJ, Pooler J, Prothero D, Bannister GC (1994) Factors affecting the outcome after proximal femoral fractures. Injury 25:297–300PubMed Fox HJ, Pooler J, Prothero D, Bannister GC (1994) Factors affecting the outcome after proximal femoral fractures. Injury 25:297–300PubMed
19.
go back to reference Grisso JA, Kelsey JL, Strom BL et al (1991) Risk factors for falls as a cause of hip fracture in women. N Engl J Med 324:1326–1331 Grisso JA, Kelsey JL, Strom BL et al (1991) Risk factors for falls as a cause of hip fracture in women. N Engl J Med 324:1326–1331
20.
go back to reference Guyton JL (1998) Fractures of hip, acetabulum and pelvis. In: Canale ST (ed) Campbell’s operative orthopaedics, 9th edn. Mosby, St. Louis, pp 2181–2183 Guyton JL (1998) Fractures of hip, acetabulum and pelvis. In: Canale ST (ed) Campbell’s operative orthopaedics, 9th edn. Mosby, St. Louis, pp 2181–2183
21.
go back to reference Hamilton BH, Hamilton VH, Mayo NE (1996) What are the costs of queuing for hip fracture surgery in Canada? J Health Econ 15:161–185CrossRefPubMed Hamilton BH, Hamilton VH, Mayo NE (1996) What are the costs of queuing for hip fracture surgery in Canada? J Health Econ 15:161–185CrossRefPubMed
22.
go back to reference Hamlet WP, Lieberman JR, Freedman EL, Dorey FJ, Fletcher A, Johnson EE (1997) Influence of health status and the timing of surgery on mortality in hip fracture patients. Am J Orthop 26:621–627PubMed Hamlet WP, Lieberman JR, Freedman EL, Dorey FJ, Fletcher A, Johnson EE (1997) Influence of health status and the timing of surgery on mortality in hip fracture patients. Am J Orthop 26:621–627PubMed
23.
go back to reference Hefley FG Jr, Nelson CL, Puskarich-May CL (1996) Effect of delayed admission to the hospital on the preoperative prevalence of deep-vein thrombosis associated with fractures about the hip. J Bone Joint Surg Am 78:581–583PubMed Hefley FG Jr, Nelson CL, Puskarich-May CL (1996) Effect of delayed admission to the hospital on the preoperative prevalence of deep-vein thrombosis associated with fractures about the hip. J Bone Joint Surg Am 78:581–583PubMed
24.
go back to reference Hoerer D, Volpin G, Stein H (1993) Results of early and delayed surgical fixation of hip fractures in the elderly: a comparative retrospective study. Bull Hosp Jt Dis 53:29–33 Hoerer D, Volpin G, Stein H (1993) Results of early and delayed surgical fixation of hip fractures in the elderly: a comparative retrospective study. Bull Hosp Jt Dis 53:29–33
25.
go back to reference Kenzora JE, McCarthy RE, Drennan Lowell J, Sledge CB (1984) Hip fracture mortality. Relation to age, treatment, preoperative illness, time of surgery, and complications. Clin Orthop 186:45–56PubMed Kenzora JE, McCarthy RE, Drennan Lowell J, Sledge CB (1984) Hip fracture mortality. Relation to age, treatment, preoperative illness, time of surgery, and complications. Clin Orthop 186:45–56PubMed
26.
go back to reference Kleinbaum DG (1996) Survival analysis. A self-learning text. Springer, Berlin Heidelberg New York Kleinbaum DG (1996) Survival analysis. A self-learning text. Springer, Berlin Heidelberg New York
27.
go back to reference Koval KJ, Zuckerman JD (1994) Hip fractures. I. Overview and evaluation and treatment of femoral-neck fractures. J Am Acad Orthop Surg 2:141–149PubMed Koval KJ, Zuckerman JD (1994) Hip fractures. I. Overview and evaluation and treatment of femoral-neck fractures. J Am Acad Orthop Surg 2:141–149PubMed
29.
go back to reference Morris AH, Zuckerman JD (2002) National Consensus Conference on Improving the Continuum of Care for Patients with Hip Fracture. J Bone Joint Surg Am 84:670–674 Morris AH, Zuckerman JD (2002) National Consensus Conference on Improving the Continuum of Care for Patients with Hip Fracture. J Bone Joint Surg Am 84:670–674
30.
go back to reference Mullen JO, Mullen NL (1992) Hip fracture mortality. A prospective, multifactorial study to predict and minimize death risk. Clin Orthop 280:214–222PubMed Mullen JO, Mullen NL (1992) Hip fracture mortality. A prospective, multifactorial study to predict and minimize death risk. Clin Orthop 280:214–222PubMed
31.
go back to reference Nightingale S, Holmes J, Mason J, House A (2001) Psychiatric illness and mortality after hip fracture. Lancet 357:1264–1265CrossRefPubMed Nightingale S, Holmes J, Mason J, House A (2001) Psychiatric illness and mortality after hip fracture. Lancet 357:1264–1265CrossRefPubMed
32.
go back to reference Perez JV, Warwick DJ, Case CP, Bannister GC (1995) Death after proximal femur fracture—an autopsy study. Injury 26:237–240CrossRefPubMed Perez JV, Warwick DJ, Case CP, Bannister GC (1995) Death after proximal femur fracture—an autopsy study. Injury 26:237–240CrossRefPubMed
33.
go back to reference Poor G, Atkinson EJ, O’Fallon WM, Melton LJ 3rd (1995) Determinants of reduced survival following hip fractures in men. Clin Orthop 319:260–265PubMed Poor G, Atkinson EJ, O’Fallon WM, Melton LJ 3rd (1995) Determinants of reduced survival following hip fractures in men. Clin Orthop 319:260–265PubMed
34.
go back to reference Sexson SB, Lehner JT (1987) Factors affecting hip fracture mortality. J Orthop Trauma 1:298–305PubMed Sexson SB, Lehner JT (1987) Factors affecting hip fracture mortality. J Orthop Trauma 1:298–305PubMed
35.
go back to reference Sherk HH, Snape WJ, Loprete FL (1979) Internal fixation versus non-treatment of hip fractures in senile patients. Clin Orthop 141:196–198PubMed Sherk HH, Snape WJ, Loprete FL (1979) Internal fixation versus non-treatment of hip fractures in senile patients. Clin Orthop 141:196–198PubMed
36.
go back to reference Todd CJ, Freeman CJ, Camilleri-Ferrante C et al (1995) Differences in mortality after fracture of hip: the East Anglian audit. BMJ 310:904–908PubMed Todd CJ, Freeman CJ, Camilleri-Ferrante C et al (1995) Differences in mortality after fracture of hip: the East Anglian audit. BMJ 310:904–908PubMed
37.
go back to reference Walter LC, Lui LY, Eng C, Covinsky KE (2003) Risk of hip fracture in disabled community-living older adults. J Am Geriatr Soc 5:50–55CrossRef Walter LC, Lui LY, Eng C, Covinsky KE (2003) Risk of hip fracture in disabled community-living older adults. J Am Geriatr Soc 5:50–55CrossRef
38.
go back to reference White BL, Fisher WD, Laurin CA (1987) Rate of mortality for elderly patients after fracture of the hip in the 1980’s. J Bone Joint Surg Am 69:1335–1340 White BL, Fisher WD, Laurin CA (1987) Rate of mortality for elderly patients after fracture of the hip in the 1980’s. J Bone Joint Surg Am 69:1335–1340
40.
go back to reference Zuckerman JD, Skovron ML, Koval KJ, Aharonoff G, Frankel VH (1995) Postoperative complications and mortality associated with operative delay in older patients who have a fracture of the hip. J Bone Joint Surg Am 77:1551–1556PubMed Zuckerman JD, Skovron ML, Koval KJ, Aharonoff G, Frankel VH (1995) Postoperative complications and mortality associated with operative delay in older patients who have a fracture of the hip. J Bone Joint Surg Am 77:1551–1556PubMed
Metadata
Title
Morbidity and mortality after hip fracture: the impact of operative delay
Authors
Michael Gdalevich
Dani Cohen
Dina Yosef
Chanan Tauber
Publication date
01-06-2004
Publisher
Springer-Verlag
Published in
Archives of Orthopaedic and Trauma Surgery / Issue 5/2004
Print ISSN: 0936-8051
Electronic ISSN: 1434-3916
DOI
https://doi.org/10.1007/s00402-004-0662-9

Other articles of this Issue 5/2004

Archives of Orthopaedic and Trauma Surgery 5/2004 Go to the issue