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Archives of Orthopaedic and Trauma Surgery

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01-12-2003 | Original Article

Remodelling and healing process of moderately heat-treated bone grafts after wide resection of bone and soft-tissue tumors

Authors: H. Sugiura, S. Yamamura, K. Sato, H. Katagiri, Y. Nishida, H. Nakashima, Y. Yamada

Published in: Archives of Orthopaedic and Trauma Surgery | Issue 10/2003

Abstract

Introduction

In the reconstruction of extensive bone defects after massive resection of malignant musculoskeletal tumors, the clinical results of moderately heat-treated autogenous bone graft have rarely been documented. We evaluated the remodelling and healing process of moderately heat-treated autogenous bone graft by means of imaging features.

Materials and methods

The subjects of this study were 19 patients with bone and soft-tissue tumors treated by heat-treated bone graft at our institution between 1992 and 2001, the mean follow-up period was 4.8±2.8 years (range 1–9 years). The remodelling and healing process of heat-treated bone graft was evaluated by means of radiography, bone scintigraphy, and MRI.

Results

The mean period to obtain bone union between host bone and grafted bone was 9.4 months. Infection was noted in 1 patient, and fracture was present in 2 patients. In 6 patients, pseudoarthrosis was found. Bone scintigraphy showed an increased uptake at the host-graft junction in the period between 3 and 36 months (median 10.7 months) postoperatively. A gradually increased diffuse uptake on the grafted side was evident at an average of 29.1 months (range 19–41 months) postoperatively. High signal intensity on T2-weighted images was observed in the early period after surgery, and iso-intense or low signal intensity became evident after an average of 28.3 months. A gradually increased diffuse uptake on scintigraphy and iso-intense or low signal intensity on T2-weighted images indicated remodelling of the grafted bone.

Conclusion

Bone union of a moderately heat-treated autogenous bone graft was noted at about 9 months, and its remodelling was proceeding at about 30 months. This method will be useful for bone defects after massive resection of soft-tissue and bone tumors.

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Title: Remodelling and healing process of moderately heat-treated bone grafts after wide resection of bone and soft-tissue tumors
Authors: H. Sugiura
S. Yamamura
K. Sato
H. Katagiri
Y. Nishida
H. Nakashima
Y. Yamada
Publication date: 01-12-2003
Publisher: Springer-Verlag
Published in: Archives of Orthopaedic and Trauma Surgery / Issue 10/2003
Print ISSN: 0936-8051
Electronic ISSN: 1434-3916
DOI: https://doi.org/10.1007/s00402-003-0556-2

At a glance: The STEP trials

Springer Medicine

Remodelling and healing process of moderately heat-treated bone grafts after wide resection of bone and soft-tissue tumors

Abstract

Introduction

Materials and methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Introduction

Materials and methods

Results

Conclusion

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