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Published in: Acta Neuropathologica 3/2019

01-09-2019 | Parkinson's Disease | Review

Neurotoxicity of pesticides

Authors: Jason R. Richardson, Vanessa Fitsanakis, Remco H. S. Westerink, Anumantha G. Kanthasamy

Published in: Acta Neuropathologica | Issue 3/2019

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Abstract

Pesticides are unique environmental contaminants that are specifically introduced into the environment to control pests, often by killing them. Although pesticide application serves many important purposes, including protection against crop loss and against vector-borne diseases, there are significant concerns over the potential toxic effects of pesticides to non-target organisms, including humans. In many cases, the molecular target of a pesticide is shared by non-target species, leading to the potential for untoward effects. Here, we review the history of pesticide usage and the neurotoxicity of selected classes of pesticides, including insecticides, herbicides, and fungicides, to humans and experimental animals. Specific emphasis is given to linkages between exposure to pesticides and risk of neurological disease and dysfunction in humans coupled with mechanistic findings in humans and animal models. Finally, we discuss emerging techniques and strategies to improve translation from animal models to humans.
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Metadata
Title
Neurotoxicity of pesticides
Authors
Jason R. Richardson
Vanessa Fitsanakis
Remco H. S. Westerink
Anumantha G. Kanthasamy
Publication date
01-09-2019
Publisher
Springer Berlin Heidelberg
Published in
Acta Neuropathologica / Issue 3/2019
Print ISSN: 0001-6322
Electronic ISSN: 1432-0533
DOI
https://doi.org/10.1007/s00401-019-02033-9

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