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Acta Neuropathologica
Published in: Acta Neuropathologica 2/2017

01-08-2017 | Correspondence

NG2 plays a role in neuroinflammation but is not expressed by immune cells

Authors: Maja Kitic, Khalad Karram, Nicole Israel, Nir Yogev, Sonja M. Lacher, Yilang Tang, Hatice Yigit, Jan Bauer, Florian Wanke, Anela Knezovic, Jacqueline Trotter, Florian C. Kurschus, Ari Waisman

Published in: Acta Neuropathologica | Issue 2/2017

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Excerpt

Nerve/glial antigen 2 (NG2) is a large transmembrane chondroitin sulphate proteoglycan expressed mainly by oligodendrocyte precursor cells in the developing and adult central nervous system (CNS) and pericytes in various organs throughout the body [14]. Numerous studies reported increased levels of this molecule after CNS injury, but its relevance remained questionable [5, 6, 9, 11]. …
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Literature
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Karram K, Goebbels S, Schwab M, Jennissen K, Seifert G, Steinhauser C et al (2008) NG2-expressing cells in the nervous system revealed by the NG2-EYFP-knockin mouse. Genesis 46:743–757CrossRefPubMed
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Yotsumoto F, You W-K, Cejudo-Martin P, Kucharova K, Sakimura K, Stallcup WB (2015) NG2 proteoglycan-dependent recruitment of tumor macrophages promotes pericyte-endothelial cell interactions required for brain tumor vascularization. Oncoimmunology 4:e1001204CrossRefPubMedPubMedCentral
Metadata
Title
NG2 plays a role in neuroinflammation but is not expressed by immune cells
Authors
Maja Kitic
Khalad Karram
Nicole Israel
Nir Yogev
Sonja M. Lacher
Yilang Tang
Hatice Yigit
Jan Bauer
Florian Wanke
Anela Knezovic
Jacqueline Trotter
Florian C. Kurschus
Ari Waisman
Publication date
01-08-2017
Publisher
Springer Berlin Heidelberg
Published in
Acta Neuropathologica / Issue 2/2017
Print ISSN: 0001-6322
Electronic ISSN: 1432-0533
DOI
https://doi.org/10.1007/s00401-017-1735-5

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