Published in:
01-08-2016 | Correspondence
Significant association of cadaveric dura mater grafting with subpial Aβ deposition and meningeal amyloid angiopathy
Authors:
Tsuyoshi Hamaguchi, Yu Taniguchi, Kenji Sakai, Tetsuyuki Kitamoto, Masaki Takao, Shigeo Murayama, Yasushi Iwasaki, Mari Yoshida, Hiroshi Shimizu, Akiyoshi Kakita, Hitoshi Takahashi, Hiroyoshi Suzuki, Hironobu Naiki, Nobuo Sanjo, Hidehiro Mizusawa, Masahito Yamada
Published in:
Acta Neuropathologica
|
Issue 2/2016
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Excerpt
Recently, the possibility of human-to-human transmission of cerebral β-amyloidosis has been suggested in autopsy studies of patients with iatrogenic Creutzfeldt–Jakob disease (CJD) associated with human growth hormone injection or dura mater graft [
1,
3,
4]. To evaluate the possibility of iatrogenic transmission of cerebral β-amyloidosis in humans via cadaveric dura mater graft, we performed immunohistochemical studies on 16 patients with dura mater graft-associated CJD (dCJD) and 21 patients with sporadic CJD (sCJD) using antibodies against prion protein (PrP), amyloid β-protein (Aβ), phosphorylated tau, phosphorylated α-synuclein, and phosphorylated transactive response DNA-binding protein-43 (TDP-43) (see supplementary methods). There were no significant differences between patients with dCJD and sCJD with respect to age at death [mean ± SD (range) years: 63.1 ± 14.1 (35–81) and 63.4 ± 10.8 (35–80), respectively], sex distribution, duration of CJD [months: 18.1 ± 8.8 (7–41) and 22.7 ± 13.9 (4–60), respectively], distribution of polymorphisms at codon 129 of PrP gene or in the apolipoprotein E gene, or PrP deposition score [
6] (supplementary Table 1; supplementary Fig. 1). …