Top

Published in:

01-05-2016 | Editorial

Cerebrovascular pathology: the dark side of neurodegeneration

Authors: Roxana O. Carare, Rajesh Kalaria

Published in: Acta Neuropathologica | Issue 5/2016

Excerpt

It is widely recognised that cerebrovascular disorders contribute to the burden of physical morbidity and mortality in a major way. More profoundly, injury or ageing-related structural and functional disturbances in the macro- or microcirculation of the brain make it vulnerable to cognitive dysfunction and change in behaviour. Although cause and effect are not completely understood, it is apparent that cerebral hypoperfusion and impaired drainage of interstitial fluid and soluble metabolites are recurrent themes during brain ageing. The cluster on cerebrovascular disorders in this issue of Acta Neuropathologica focuses on pathophysiological mechanisms associated with brain ageing and dementia, particularly Alzheimer’s disease, bringing together the latest results, novel angles and working hypotheses. The following articles advance our knowledge of the clinical, diagnostic, imaging and physiological aspects as they relate to the neuropathology of cerebrovascular disorders and Alzheimer’s disease. …

Carare RO, Hawkes CA, Jeffrey M, Kalaria RN, Weller RO (2013) Review: cerebral amyloid angiopathy, prion angiopathy, CADASIL and the spectrum of protein elimination failure angiopathies (PEFA) in neurodegenerative disease with a focus on therapy. Neuropathol Appl Neurobiol 39:593–611. doi:10.1111/nan.12042 CrossRefPubMed

Grinberg LT, Thal DR (2010) Vascular pathology in the aged human brain. Acta Neuropathol 119:277–290. doi:10.1007/s00401-010-0652-7 CrossRefPubMedPubMedCentral

Kalaria R (2016) Neuropathological diagnosis of vascular cognitive impairment and vascular dementia with implications for Alzheimer’s disease. Acta Neuropathol. doi:10.1007/s00401-016-1571-z (in press)

Love S, Miners S (2016) Cerebrovascular disease in ageing and Alzheimer’s disease. Acta Neuropathol. doi:10.1007/s00401-015-1522-0 (in press)

Merlini M, Wanner D, Nitsch RM (2016) Tau pathology-dependent remodelling of cerebral arteries precedes Alzheimer’s disease-related microvascular cerebral amyloid angiopathy. Acta Neuropathol. doi: 10.1007/s00401-016-1560-2 (in press)

Montagne A, Nation DA, Pa J, Toga AW, Zlokovic BV (2016) Brain imaging of neurovascular dysfunction in Alzheimer’s disease. Acta Neuropathol (in press)

Montine TJ, Phelps CH, Beach TG, Bigio EH, Cairns NJ, Dickson DW, Duyckaerts C, Frosch MP, Masliah E, Mirra SS et al (2012) National Institute on Aging-Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach. Acta Neuropathol 123:1–11. doi:10.1007/s00401-011-0910-3 CrossRefPubMedPubMedCentral

Morris AJW, Sharp MM, Albargothy NJ, Fernandes R, Hawkes CA, Verma A, Weller RO, Carare RO (2016) Vascular basement membranes as pathways for the passage of fluid into and out of the brain. Acta Neuropathol. doi:10.1007/s00401-016-1555-z (in press)

Tai LM, Thomas R, M. MF, Koster KP, Kanekiyo T, Morris AJW, Bu G (2016) The role of APOE in cerebrovascular dysfunction. Acta Neuropathol. doi:10.1007/s00401-016-1547-z (in press)

10.

Toledo JB, Arnold SE, Raible K, Brettschneider J, Xie SX, Grossman M, Monsell SE, Kukull WA, Trojanowski JQ (2013) Contribution of cerebrovascular disease in autopsy confirmed neurodegenerative disease cases in the National Alzheimer’s Coordinating Centre. Brain 136:2697–2706. doi:10.1093/brain/awt188 CrossRefPubMedPubMedCentral

Title: Cerebrovascular pathology: the dark side of neurodegeneration
Authors: Roxana O. Carare
Rajesh Kalaria
Publication date: 01-05-2016
Publisher: Springer Berlin Heidelberg
Published in: Acta Neuropathologica / Issue 5/2016
Print ISSN: 0001-6322
Electronic ISSN: 1432-0533
DOI: https://doi.org/10.1007/s00401-016-1573-x

At a glance: The STEP trials

Springer Medicine

Cerebrovascular pathology: the dark side of neurodegeneration

Excerpt

At a glance: The STEP trials

Springer Medicine

Excerpt

Please log in to get access to this content

Other articles of this Issue 5/2016

Brain imaging of neurovascular dysfunction in Alzheimer’s disease

Commentary on “Histone H3F3A and HIST1H3B K27M mutations define two subgroups of diffuse intrinsic pontine gliomas with different prognosis and phenotypes”

Cerebrovascular disease in ageing and Alzheimer’s disease

The role of APOE in cerebrovascular dysfunction

Cell therapy centered on IL-1Ra is neuroprotective in experimental stroke

Neuropathological diagnosis of vascular cognitive impairment and vascular dementia with implications for Alzheimer’s disease