Published in:
01-05-2016 | Correspondence
Commentary on “Histone H3F3A and HIST1H3B K27M mutations define two subgroups of diffuse intrinsic pontine gliomas with different prognosis and phenotypes”
Authors:
Marc H. A. Jansen, Sophie E. M. Veldhuijzen van Zanten, Martijn W. Heymans, Darren Hargrave, Christof M. Kramm, Dannis G. Van Vuurden
Published in:
Acta Neuropathologica
|
Issue 5/2016
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Excerpt
We have read with interest the recent publication by Castel et al., describing the identification of two prognostic subgroups within diffuse intrinsic pontine glioma (DIPG) based on H3.1 versus H3.3-mutation status. They report that these mutations underlie mutually exclusive oncogenetic pathways and hence two phenotypic subgroups, which may eventually lead to specific subgroup treatment for DIPG patients. Although we advocate the search for new predictors in DIPG, we do, however, have some concerns regarding the authors’ statement that histone mutation status is a better predictor for prognosis compared to our recently published prediction model (the DIPG risk score), which is based on clinical and radiological criteria [
2]. …
