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01-09-2015 | Correspondence

High frequency of H3F3A ^K27M mutations characterizes pediatric and adult high-grade gliomas of the spinal cord

Authors: Marco Gessi, Gerrit H. Gielen, Verena Dreschmann, Andreas Waha, Torsten Pietsch

Published in: Acta Neuropathologica | Issue 3/2015

Excerpt

Diffuse high-grade gliomas (HGG) in the spinal cord are rare [5]. It is still undetermined whether they could share genetic alterations with their supratentorial counterparts: in particular, because the spinal cord has to be considered a midline structure, a high incidence of H3F3A ^K27M mutations could be hypothesized, as reported in diffuse pontine gliomas (DIPG) and in pediatric midline HGG [1‐3, 6‐8]. In this study, we investigated the H3F3A ^K27M status of 30 primary spinal HGG affecting pediatric and adult patients. …

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Title: High frequency of H3F3A K27M mutations characterizes pediatric and adult high-grade gliomas of the spinal cord
Authors: Marco Gessi
Gerrit H. Gielen
Verena Dreschmann
Andreas Waha
Torsten Pietsch
Publication date: 01-09-2015
Publisher: Springer Berlin Heidelberg
Published in: Acta Neuropathologica / Issue 3/2015
Print ISSN: 0001-6322
Electronic ISSN: 1432-0533
DOI: https://doi.org/10.1007/s00401-015-1463-7

At a glance: The STEP trials

Springer Medicine

High frequency of H3F3A ^K27M mutations characterizes pediatric and adult high-grade gliomas of the spinal cord

Excerpt

At a glance: The STEP trials

Springer Medicine

Excerpt

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