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01-04-2015 | Correspondence

High rate of concurrent BRAF-KIAA1549 gene fusion and 1p deletion in disseminated oligodendroglioma-like leptomeningeal neoplasms (DOLN)

Authors: Fausto J. Rodriguez, Matthew J. Schniederjan, Theo Nicolaides, Tarik Tihan, Peter C. Burger, Arie Perry

Published in: Acta Neuropathologica | Issue 4/2015

Excerpt

Disseminated oligodendroglioma-like leptomeningeal neoplasm (DOLN) is a recently described entity that predominantly affects children, is slowly progressive, and exhibits little, if any, parenchymal involvement. Studies to date have demonstrated some similarities between DOLNs and adult oligodendrogliomas with respect to morphology (infiltrative, monotonous cells with round, regular nuclei and perinuclear clearing), immunohistochemistry (synaptophysin, GFAP, Olig-2 expression), and genetics (high rate of chromosome 1p deletions and some 1p19q co-deletions) [5‐8]. In contrast however, no DOLNs have been shown to harbor the isocitrate dehydrogenase-1 (IDH1) R132H mutation. …

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Title: High rate of concurrent BRAF-KIAA1549 gene fusion and 1p deletion in disseminated oligodendroglioma-like leptomeningeal neoplasms (DOLN)
Authors: Fausto J. Rodriguez
Matthew J. Schniederjan
Theo Nicolaides
Tarik Tihan
Peter C. Burger
Arie Perry
Publication date: 01-04-2015
Publisher: Springer Berlin Heidelberg
Published in: Acta Neuropathologica / Issue 4/2015
Print ISSN: 0001-6322
Electronic ISSN: 1432-0533
DOI: https://doi.org/10.1007/s00401-015-1400-9

At a glance: The STEP trials

Springer Medicine

High rate of concurrent BRAF-KIAA1549 gene fusion and 1p deletion in disseminated oligodendroglioma-like leptomeningeal neoplasms (DOLN)

Excerpt

At a glance: The STEP trials

Springer Medicine

Excerpt

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