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Acta Neuropathologica
Published in: Acta Neuropathologica 6/2014

01-06-2014 | Correspondence

FGFR1 N546K mutation in a case of papillary glioneuronal tumor (PGNT)

Authors: Marco Gessi, Yasmin Abdel Moneim, Jennifer Hammes, Andreas Waha, Torsten Pietsch

Published in: Acta Neuropathologica | Issue 6/2014

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Excerpt

Papillary glioneuronal tumors (PGNTs) are rare neoplasms affecting young adults, that usually are characterized by an indolent clinical behavior. They are often cystic and arise in the temporal lobe or in the periventricular white matter. Histologically, PGNTs are described in the revised WHO classification (2007) as a biphasic neoplasm characterized by papillary or pseudo-papillary architecture, formed by glial cells and an intervening neuronal component with cells ranging from neurocytes to ganglion cells [4]. Information regarding their molecular features is relatively limited [4]. In this report, we describe for the first time the presence of a N546K mutation of FGFR1 gene in a PGNT arising in the frontal lobe. …
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Nakazato Y, Figarella-Branger D, Becker AJ, Scheithauer BW, Rosenblum MK (2007) Papillary glioneuronal tumor. In: Louis DN, Ohgaki H, Wiestler OD, Cavenee WK (eds) WHO classification of tumours of the central nervous system, 4th edn. IARC press, Lyon, pp 113–114
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Metadata
Title
FGFR1 N546K mutation in a case of papillary glioneuronal tumor (PGNT)
Authors
Marco Gessi
Yasmin Abdel Moneim
Jennifer Hammes
Andreas Waha
Torsten Pietsch
Publication date
01-06-2014
Publisher
Springer Berlin Heidelberg
Published in
Acta Neuropathologica / Issue 6/2014
Print ISSN: 0001-6322
Electronic ISSN: 1432-0533
DOI
https://doi.org/10.1007/s00401-014-1283-1

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