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01-04-2014 | Correspondence

Supratentorial ependymomas of childhood carry C11orf95–RELA fusions leading to pathological activation of the NF-κB signaling pathway

Authors: Torsten Pietsch, Inken Wohlers, Tobias Goschzik, Verena Dreschmann, Dorota Denkhaus, Evelyn Dörner, Sven Rahmann, Ludger Klein-Hitpass

Published in: Acta Neuropathologica | Issue 4/2014

Excerpt

Clinical observations and studies on genetic alterations and gene expression indicated that supratentorial ependymomas differ from ependymomas of infratentorial or spinal location [6, 8]. To further elucidate the pathogenesis of supratentorial ependymomas, we performed paired-end RNA sequencing in 19 tumor samples from 18 patients (for clinical data, see Supplementary Table 1). Mapping of the reads predicted a novel recurrent fusion mRNA between C11orf95, a gene with unknown function, and v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA) encoding the RelA p65 subunit of the central NF-κB complex. RELA is located approximately 1.9 Mbp telomeric from C11orf95 on the same chromosomal band 11q13. …

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Title: Supratentorial ependymomas of childhood carry C11orf95–RELA fusions leading to pathological activation of the NF-κB signaling pathway
Authors: Torsten Pietsch
Inken Wohlers
Tobias Goschzik
Verena Dreschmann
Dorota Denkhaus
Evelyn Dörner
Sven Rahmann
Ludger Klein-Hitpass
Publication date: 01-04-2014
Publisher: Springer Berlin Heidelberg
Published in: Acta Neuropathologica / Issue 4/2014
Print ISSN: 0001-6322
Electronic ISSN: 1432-0533
DOI: https://doi.org/10.1007/s00401-014-1264-4

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Supratentorial ependymomas of childhood carry C11orf95–RELA fusions leading to pathological activation of the NF-κB signaling pathway

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