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Published in: Acta Neuropathologica 6/2013

01-12-2013 | Editorial

Making sense of the antisense transcripts in C9FTD/ALS

Author: Peter K. Todd

Published in: Acta Neuropathologica | Issue 6/2013

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Excerpt

In medicine, Occam’s razor is employed to enforce diagnostic parsimony upon complicated cases. Stated simply, Occam’s razor says that the single disease that best accounts for all of a patient’s symptoms is likely to be the primary cause of all of them. In biomedical research, a similar logic is often applied, triggering searches for a single central pathogenic mechanism as the primary (or sole) pathway that causes a given disease. The rationale for this approach is clear: only when we know the one true cause of a disease can we know where to focus our efforts for therapeutic development. In this issue of Acta Neuropathologica, five new papers suggest that successful application of Occam’s razor to the recently described C9-associated frontotemporal dementia and amyotrophic lateral sclerosis (C9FTD/ALS) is going to be a challenge. …
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Metadata
Title
Making sense of the antisense transcripts in C9FTD/ALS
Author
Peter K. Todd
Publication date
01-12-2013
Publisher
Springer Berlin Heidelberg
Published in
Acta Neuropathologica / Issue 6/2013
Print ISSN: 0001-6322
Electronic ISSN: 1432-0533
DOI
https://doi.org/10.1007/s00401-013-1201-y

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