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Acta Neuropathologica
Published in: Acta Neuropathologica 1/2013

01-07-2013 | Correspondence

Olfactory impairment and pathology in neurodegenerative disorders with brain iron accumulation

Authors: Dorota Dziewulska, Hiroshi Doi, Alfonso Fasano, Roberto Erro, Farzad Fatehi, Robert Fekete, Emilia M. Gatto, Emilio Gonzalez Pablos, Alexander Lehn, Hiroaki Miyajima, Alberto Piperno, Maria Teresa Pellechia, Yih-ru Wu, Kunihiro Yoshida, Juan G. Zarruk, Shan Jingli, Anette Schrag, Alisdair McNeill

Published in: Acta Neuropathologica | Issue 1/2013

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Excerpt

Neurodegenerative disorders with brain iron accumulation (NBIA) are a clinically and genetically heterogeneous group of neurodegenerative diseases featuring excessive brain iron deposition [2]. Iron deficient mice display impaired olfactory behaviour and chronic exposure to airborne iron particles is associated with hyposmia [4]. We hypothesised that dysregulated brain iron metabolism in NBIA might be associated with hyposmia. We tested olfactory function in a group of NBIA patients and performed histological examination of olfactory tissue from patients with NBIA and a mouse NBIA model for iron deposition. …
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Literature
1.
Doty RL (2012) Olfaction in Parkinson’s disease and related disorders. Neurobiol Dis 46:527–552PubMedCrossRef
2.
McNeill A, Chinnery PF (2011) Neurodegeneration with brain iron accumulation. Handb Clin Neurol 100:161–172PubMedCrossRef
3.
Patel BN, Dunn RJ, Jeong SY, Zhu Q, Julien JP, David S (2002) Ceruloplasmin regulates iron levels in the CNS and prevents free radical injury. J Neurosci 22:6578–6586PubMed
4.
Ruvin Kumara VM, Wessling-Resnick M (2012) Influence of iron deficiency on olfactory behaviour in weanling rats. J Behav Brain Sci 2:167–175CrossRef
Metadata
Title
Olfactory impairment and pathology in neurodegenerative disorders with brain iron accumulation
Authors
Dorota Dziewulska
Hiroshi Doi
Alfonso Fasano
Roberto Erro
Farzad Fatehi
Robert Fekete
Emilia M. Gatto
Emilio Gonzalez Pablos
Alexander Lehn
Hiroaki Miyajima
Alberto Piperno
Maria Teresa Pellechia
Yih-ru Wu
Kunihiro Yoshida
Juan G. Zarruk
Shan Jingli
Anette Schrag
Alisdair McNeill
Publication date
01-07-2013
Publisher
Springer-Verlag
Published in
Acta Neuropathologica / Issue 1/2013
Print ISSN: 0001-6322
Electronic ISSN: 1432-0533
DOI
https://doi.org/10.1007/s00401-013-1136-3

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