Globular glial-like inclusions in a patient with advanced Alzheimer’s disease

Excerpt

We read with interest the article by Ahmed and colleagues [1] entitled “Globular glial tauopathies (GGT) presenting with motor neuron disease or frontotemporal dementia: an emerging group of 4-repeat tauopathies.” The authors present clinical, neuropathological and biochemical features of two patients, one with frontotemporal dementia (FTD) and the other with motor neuron disease (MND), both sharing the presence of characteristic globular glial 4-repeat tau positive inclusions (oligodendroglial and astrocytic) with different topographical distribution. Previously, Kovacs et al. [3] described in detail seven cases showing FTLD phenotype and abundant white matter globular glial inclusions. Both authors suggest grouping previous terms such as MSTD or FTD-P-MND/PSP-CST, in one encompassing term, as this pathology seems to represent a separate entity among tauopathies. …