Published in:
01-02-2012 | Correspondence
Recurrent PIK3CA mutations in rosette-forming glioneuronal tumor
Authors:
Benjamin Ellezam, Brett J. Theeler, Rajyalakshmi Luthra, Adekunle M. Adesina, Kenneth D. Aldape, Mark R. Gilbert
Published in:
Acta Neuropathologica
|
Issue 2/2012
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Excerpt
Rosette-forming glioneuronal tumor (RGNT) is a recently described CNS neoplasm generally involving posterior midline structures with frequent extension in the fourth ventricle [
5]. With only one case of postoperative recurrence reported to date [
8], RGNT is considered to have favorable outcome and the current standard of care is surgical excision without adjuvant therapy. To date, no molecular alterations have been reported for this tumor. Alterations in the
PI3K/AKT pathway are frequent in many cancers [
11] and have been reported in CNS tumors [
1,
2,
6,
7]. Here, we report the identification of frequent
PIK3CA mutations in a series of RGNTs reviewed at our institution. …
