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01-02-2011 | Editorial

Tau pathology in children and young adults: can you still be unconditionally baptist?

Author: Charles Duyckaerts

Published in: Acta Neuropathologica | Issue 2/2011

Excerpt

The lesions of Alzheimer Disease (AD) pathology, senile plaques and neurofibrillary tangles, are made of an accumulation of Aβ peptide in the extracellular space and of tau protein in the neurons. The discovery that a mutation of the amyloid precursor protein (APP) gene was able to induce AD, naturally led to conclude that Aβ was the initiator and tau, the follower. The “cascade hypothesis” according to which the trigger is Aβ accumulation [8] was further supported by the finding that mutations of MAPT, the tau gene, cause a pure tauopathy without Aβ accumulation [9, 13]. …

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Title: Tau pathology in children and young adults: can you still be unconditionally baptist?
Author: Charles Duyckaerts
Publication date: 01-02-2011
Publisher: Springer-Verlag
Published in: Acta Neuropathologica / Issue 2/2011
Print ISSN: 0001-6322
Electronic ISSN: 1432-0533
DOI: https://doi.org/10.1007/s00401-010-0794-7

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Tau pathology in children and young adults: can you still be unconditionally baptist?

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