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Acta Neuropathologica
Published in: Acta Neuropathologica 5/2009

Open Access 01-11-2009 | Case Report

Vacuolar myopathy in a dog resembling human sporadic inclusion body myositis

Authors: Jason King, Richard A. LeCouteur, Monica Aleman, D. Colette Williams, Peter F. Moore, Ling T. Guo, Andrew P. Mizisin, G. Diane Shelton

Published in: Acta Neuropathologica | Issue 5/2009

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Abstract

Sporadic inclusion body myositis (sIBM) is the most common myopathy in people over the age of 50 years. While immune-mediated inflammatory myopathies are well documented in dogs, sIBM has not been described. An 11-year-old dog with chronic and progressive neuromuscular dysfunction was evaluated for evidence of sIBM using current pathologic, immunohistochemical and electron microscopic diagnostic criteria. Vacuoles and congophilic intracellular inclusions were identified in cryostat sections of multiple muscle biopsies and immunostained with antibodies against amyloid-β peptide, amyloid-β precursor protein, and proteosome 20S of the ubiquitin–proteosome system. Cellular infiltration and increased expression of MHC Class I antigen were observed. Cytoplasmic filamentous inclusions, membranous structures, and myeloid bodies were identified ultrastructurally. These observations constitute the first evidence that both the inflammatory and degenerative features of human sIBM can occur in a non-human species.
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Metadata
Title
Vacuolar myopathy in a dog resembling human sporadic inclusion body myositis
Authors
Jason King
Richard A. LeCouteur
Monica Aleman
D. Colette Williams
Peter F. Moore
Ling T. Guo
Andrew P. Mizisin
G. Diane Shelton
Publication date
01-11-2009
Publisher
Springer-Verlag
Published in
Acta Neuropathologica / Issue 5/2009
Print ISSN: 0001-6322
Electronic ISSN: 1432-0533
DOI
https://doi.org/10.1007/s00401-009-0588-y

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