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01-06-2009 | Correspondence

Purkinje cell axonal torpedoes are unrelated to advanced aging and likely reflect cerebellar injury

Authors: Elan D. Louis, Phyllis L. Faust, Jean-Paul G. Vonsattel, Cordelia Erickson-Davis

Published in: Acta Neuropathologica | Issue 6/2009

Excerpt

Torpedoes, swellings of the proximal Purkinje cell axon, are thought to represent a cellular response to injury [3]. They may occur in a variety of cerebellar disorders [7]. Most recently, their numbers were noted to be six-times higher in essential tremor (ET) than control brains [4]. Torpedoes are also often viewed as a cumulative phenomenon associated with advanced aging [3, 4], yet there are surprisingly few supporting data. We quantified torpedoes in normal human cerebella spanning a considerable age range to assess whether torpedoes are a cumulative phenomenon of aging. These data help place the relative abundance of torpedoes in ET in context. …

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Title: Purkinje cell axonal torpedoes are unrelated to advanced aging and likely reflect cerebellar injury
Authors: Elan D. Louis
Phyllis L. Faust
Jean-Paul G. Vonsattel
Cordelia Erickson-Davis
Publication date: 01-06-2009
Publisher: Springer-Verlag
Published in: Acta Neuropathologica / Issue 6/2009
Print ISSN: 0001-6322
Electronic ISSN: 1432-0533
DOI: https://doi.org/10.1007/s00401-009-0534-z

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Purkinje cell axonal torpedoes are unrelated to advanced aging and likely reflect cerebellar injury

Excerpt

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Excerpt

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