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Published in:

01-02-2007 | Review Article

Neurofibrillary tangle-predominant dementia: comparison with classical Alzheimer disease

Authors: K. A. Jellinger, J. Attems

Published in: Acta Neuropathologica | Issue 2/2007

Abstract

Neurofibrillary tangle predominant dementia (NFTPD) is a subset of late onset dementia, clinically different from traditional “plaque and tangle” Alzheimer disease (AD): later onset, shorter duration, less severe cognitive impairment, and almost absence of ApoE ε4. Neuropathology reveals abundant allocortical neurofibrillary pathology with no or few isocortical tau lesions, absence of neuritic plaques, absence or scarcity of amyloid deposits, but neurofibrillary changes comprising both 3 and 4 repeat (3R and 4R) tau immunohistochemistry are not significantly different from those in classical AD. Comparing 51 autopsy cases of NFTPD with 244 classical AD subjects, the nosology of NFTPD and its differences from AD are discussed.

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Title: Neurofibrillary tangle-predominant dementia: comparison with classical Alzheimer disease
Authors: K. A. Jellinger
J. Attems
Publication date: 01-02-2007
Publisher: Springer-Verlag
Published in: Acta Neuropathologica / Issue 2/2007
Print ISSN: 0001-6322
Electronic ISSN: 1432-0533
DOI: https://doi.org/10.1007/s00401-006-0156-7

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Neurofibrillary tangle-predominant dementia: comparison with classical Alzheimer disease

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