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01-07-2006 | Original Paper

Pathological Heterogeneity of the Precentral Gyrus in Pick’s Disease: A Study of 16 Autopsy Cases

Authors: Kuniaki Tsuchiya, Yue-Shan Piao, Tatsuro Oda, Akihide Mochizuki, Kunimasa Arima, Kazuko Hasegawa, Chie Haga, Akiyoshi Kakita, Koji Hori, Itaru Tominaga, Saburo Yagishita, Haruhiko Akiyama, Hitoshi Takahashi

Published in: Acta Neuropathologica | Issue 1/2006

Abstract

This report concerns the upper motor neuron involvement in 16 autopsy cases of Pick disease with Pick bodies, including 11 cases reported by us previously. Prominent, circumscribed atrophy of the precentral gyrus, conspicuously in the lower portion, was noted in one case. Loss of Betz cells and astrocytosis of the precentral gyrus layer V were encountered in 15 cases (94%) and eight cases (50%), respectively. Appearance of Pick bodies and ballooned neurons in the precentral gyrus layer V was confirmed in seven cases (44%). Degeneration of the pyramidal tract in the medulla oblongata was noted in all 15 cases in which this structure was examined. Pyramidal signs were observed in four (67%) of the six cases that were neurologically sufficiently examined: hyperreflexia in four cases (67%), spasticity in one case (17%). Babinski sign was not encountered in any of the six cases. In all four cases having pyramidal signs, degeneration of the pyramidal tract was observed. In contrast, two cases having degeneration of the pyramidal tract did not develop pyramidal signs. In Pick’s disease with Pick bodies, obvious involvement of the precentral gyrus and pyramidal tract was not previously noticed. Furthermore, we suggest that pyramidal signs in Pick’s disease with Pick bodies have been underestimated.

Alzheimer A (1911) Über eigenartige Krankheitfälle des späteren Alters. Z Ges Neurol Psychiatr 4:356–385CrossRef

Arima K (1989) Involvement of subcortical nuclei and brainstem in Pick’s disease: a topographical study of Pick bodies. Neuropathology 9:105–115

Arima K, Oyanagi S, Kosaka K, Matsushita M (1987) Distribution of Pick bodies in the central nervous system of the Pick’s disease with a special reference to their association with neuronal loss (in Japanese with English abstract). Psychiatr Neurol Jpn 89:43–72

Arima K, Akashi T (1990) Involvement of the locus coeruleus in Pick’s disease with or without Pick body formation. Acta Neuropathol 79:629–633CrossRefPubMed

Bergeron C, Morris HR, Rossor M (2003) Pick’s disease. In: Dickson DW (eds) Neurodegeneration: the molecular pathology of dementia and movement disorders. ISN Neuropath Press, Basel pp 124–131

Binetti G, Growdon JH, Vonsattel J-PG (1998) Pick’s disease. In: Growdon JH, Rossor MN (eds) The Dementias, vol 19, Blue books of practical neurology. Butterworth–Heinemann, Boston pp 7–44

Broe M, Hodges JR, Schofield E, Shepherd CE, Kril JJ, Halliday GM (2003) Staging disease severity in pathologically confirmed cases of frontotemporal dementia. Neurology 60:1005–1011PubMed

Cambier J, Masson M, Dairou R, Henin D (1981) Étude anatomo-clinique d’une forme pariétale de maladie de Pick. Rev Neurol (Paris) 137:33–38

Constantinidis J, Richard J, Tissot R (1974) Pick’s disease. Histological and clinical correlations. Eur Neurol 11:208–217PubMedCrossRef

10.

Constantinidis J (1985) Pick dementia: anatomoclinical correlations and pathophysiological considerations. In: Rose FC (eds) Interdisciplinary Topics Geront., vol 19, Modern approaches to the Dementias Part I: Etiology and pathophysiology. Karger, Basal pp 72–97

11.

Dickson DW (1998) Pick’s disease: a modern approach. Brain Pathol 8:339–354PubMedCrossRef

12.

Esiri MM, Hyman BT, Beyreuther K, Masters CL (1997) Pick’s disease. In: Graham DI, Lantos PL (eds) Greenfield’s neuropathology, sixth edition. vol II. Arnold, London, pp 192–198

13.

Hauw JJ, Duyckaerts C, Seilhean D, Camilleri S, Sazdovitch V, Rancurel G (1996) The neuropathologic diagnostic criteria of frontal lobe dementia revisited. A study of ten consecutive cases. J Neurol Transm [suppl] 47:47–59

14.

Hayashi S, Wakabayashi K, Iwanaga K, Kakita A, Seki K, Tanaka M, Okuizumi K, Onodera O, Tanaka H, Tsuji S, Takahashi H (1998) Pick’s disease: selective occurrence of apolipoprotein E-immunoreactive Pick bodies in the limbic system. Acta Neuropathol 95:1–4CrossRefPubMed

15.

Hodges JR, Davies RR, Xuereb JH, Casey B, Broe M, Bak TH, Kril JJ, Halliday GM (2004) Clinicopathological correlates in frontotemporal dementia. Ann Neurol 56:399–406CrossRefPubMed

16.

Ichimiya Y, Ikeda K, Hanawa S, Kosaka K (1984) An autopsy case of Binswanger’s disease with many Pick bodies (in Japanese). Geriatr Psychiatry 11:706–712

17.

Ikeda K, Akiyama H, Arai T, Ueno H, Tsuchiya K, Kosaka K (2002) Morphometrical reappraisal of motor neuron system of Pick’s disease and amyotrophic lateral sclerosis with dementia. Acta Neuropathol 104:21–28CrossRefPubMed

18.

Ikeda M, Ikeda K, Endoh M, Haga C, Mizutani Y (1994) An autopsied case of slowly progressive Pick’s disease (in Japanese with English abstract). Clin Psychiatry 36:1167–1171

19.

Jellinger K, Danielczyk W, Fischer P, Gabriel E (1990) Clinicopathological analysis of dementia disorders in the elderly. J Neurol Sci 95:239–258CrossRefPubMed

20.

Jellinger K (1996) Structural basis of dementia in neurodegenerative disorders. J Neural Transm [Suppl] 47:1–29

21.

Jervis GA (1971) Pick’s disease. In: Minckler J (eds) Pathology of the nervous system, vol. 2. McGraw-Hill, New York, pp 1395–1404

22.

Kersaitis C, Halliday GM, Kril JJ (2004) Regional and cellular pathology in frontotemporal dementia: relationship to stage of disease in cases with and without Pick bodies. Acta Neuropathol 108:515–523CrossRefPubMed

23.

Knopman DS, Mastri AR, Frey WHII, Sung JH, Rustan T (1990) Dementia lacking distinctive histologic features: a common non-Alzheimer degenerative dementia. Neurology 40:251–256PubMed

24.

Kosaka K, Ikeda K, Kobayashi K, Mehraein P (1991) Striatopallidonigral degeneration in Pick’s disease: a clinicopathological study of 41 cases. J Neurol 238:151–160CrossRefPubMed

25.

Lang AE, Bergeron C, Pollanen MS, Ashby P (1994) Parietal Pick’s disease mimicking cortical-basal ganglionic degeneration. Neurology 44:1436–1440PubMed

26.

Litvan I, Hauw JJ, Bartko JJ, Lantos PL, Daniel SE, Horoupian DS, McKee A, Dickson D, Bancher C, Tabaton M, Jellinger K, Anderson DW (1996) Validity and reliability of the preliminary NINDS neuropathologic criteria for progressive supranuclear palsy and related disorders. J Neuropathol Exp Neurol 55:97–105PubMedCrossRef

27.

Lüers Th, Spatz H (1957) Picksche Krankheit (Progressive umschriebene Großhirnatrophie). In: Lubarsch O, Henke F, Rössle R (eds) Handbuch der speziellen pathologischen Anatomie und Histologie, vol XIII/1A. Springer, Berlin Heidelberg New York pp 614–715

28.

Mansvelt J van (1954) Pick’s disease. A syndrome of lobar cerebral atrophy, its clinico-anatomical and histopathological types. Dissertation, Utrecht, the Netherlands

29.

Markesbery WR (1998) Pick’s disease. In: Markesbery WR (eds) Neuropathology of dementing disorders. Arnold, London, pp 142–157

30.

McGeachie RE, Fleming JO, Sharer LR, Hyman RA (1979) Diagnosis of Pick’s disease by computed tomography. J Comput Assist Tomogr 3:113–115PubMedCrossRef

31.

Mendez MF, Selwood A, Mastri AR, Frey WHII (1993) Pick’s disease versus Alzheimer’sdisease: a comparison of clinical characteristics. Neurology 43:289–292PubMed

32.

Mendez MF, Cummings JL (2003) Frontotemporal dementia and the asymmetric cortical atrophies. In: Mendez MF, Cummings JL (eds) Dementia. A clinical approach. 3rd edn. Butterworth-Heinemann, Philadelphia, pp 179–233

33.

Mirra SS, Hyman BT (2002) Pick’s disease. In: Graham DI, Lantos PL (eds) Greenfield’s neuropathology, seventh edn, vol II. Arnold, London pp 227–230

34.

Mori F, Hayashi S, Yamagishi S, Yoshimoto M, Yagihashi S, Takahashi H, Wakabayashi K (2002) Pick’s disease: α-and β-synuclein-immunoreactive Pick bodies in the dentate gyrus. Acta Neuropathol 104:455–461PubMed

35.

Morris JH (1997) Pick’s disease. In: Esiri MM, Morris JH (eds) The neuropathology of dementia. Cambridge University Press, Cambridge, pp 204–218

36.

Murayama S, Mori H, Ihara Y, Tomonaga M (1990) Immunocytochemical and ultrastructural studies of Pick’s disease. Ann Neurol 27:394–405CrossRefPubMed

37.

Odawara T, Iseki E, Kanai A, Arai T, Katsuragi T, Hino H, Furukawa Y, Kato M, Yamamoto T, Kosaka K (2003) Clinicopathological study of two subtypes of Pick’s disease in Japan. Dement Geriatr Cogn Disord 15:19–25CrossRefPubMed

38.

Onari K, Spatz H (1926) Anatomische Beiträge zur Lehre von der Pickschen umschriebenen Großhirnrinden-Atrophie (“Picksche Krankheit”). Z Ges Neurol Psychiatr 101:470–511CrossRef

39.

Oyanagi S, Tanaka M, Omori T, Matsushita M, Ishii T (1979) Regular arrangements of tubular structures in Pick bodies formed in an autopsied case of Pick’s disease (in Japanese with English abstract). Adv Neurol Sci 23:441–451

40.

Pick A (1892) Ueber die Beziehungen der senilen Hirnatrophie zur Aphasie. Prag Med Wochenschr 17:165–167

41.

Rebeiz JJ, Kolodny EH, Richardson EP Jr (1968) Corticodentatonigral degeneration with neuronal achromasia. Arch Neurol 18:20–33PubMed

42.

Richter H (1918) Eine besondere Art von Stirnhirnschwund mit Verblödung. Z Ges Neurol Psychiatr 38:127–160CrossRef

43.

Rossor MN (1999) Differential diagnosis of frontotemporal dementia: Pick’s disease. Dement Geriatr Cogn Disord 10(Suppl 1):43–45CrossRefPubMed

44.

Rossor MN, Revesz T, Lantos PL, Warrington EK (2000) Semantic dementia with ubiquitin-positive tau-negative inclusion bodies. Brain 123:267–276CrossRefPubMed

45.

Schneider C (1927) Über Picksche Krankheit. Mschr Psychiatr Neurol 65:230–275

46.

Seitelberger F, Gross H, Pilz P (1983) Pick’s disease: a neuropathologic study. In: Hirano A, Miyoshi K (eds) Neuropsychiatric disorders in the elderly. Igaku-Shoin, Tokyo pp 87–117

47.

Snowden JS, Neary D, Mann DMA (1996) Fronto-temporal lobar degeneration: front-temporal dementia, progressive aphasia, semantic dementia. Clinical Neurology and Neurosurgery Monographs. Churchill Livingstone, New York

48.

The Lund, Manchester Groups (1994) Clinical and neuropathological criteria for frontotemporal dementia. J Neurol Neurosurg Psychiatry 57:416–418PubMedCrossRef

49.

Tissot R, Constantinidis J, Richard J (1975) La maladie de Pick. Masson, Paris

50.

Tolnay M, Probst A (2002) Frontotempolar lobar degeneration–tau as a pied piper? Neurogenetics 4:63–75CrossRefPubMed

51.

Tsuchiya K, Ikeda K, Uchihara T, Oda T, Shimada H (1997) Distribution of cerebral cortical lesions in corticobasal degeneration: a clinicopathological study of five autopsy cases in Japan. Acta Neuropathol 94:416–428CrossRefPubMed

52.

Tsuchiya K, Ozawa E, Haga C, Watabiki S, Ikeda M, Sano M, Ooe K, Taki K, Ikeda K (2000) Constant involvement of the Betz cells and pyramidal tract in multiple system atrophy: a clinicopathological study of seven autopsy cases. Acta Neuropathol 99:628–636CrossRefPubMed

53.

Tsuchiya K, Mitani K, Arai T, Yamada S, Komiya T, Esaki Y, Haga C, Yamanouchi H, Ikeda K (2001) Argyrophilic grain disease mimicking temporal Pick’s disease: a clinical, radiological, and pathological study of an autopsy case with a clinical course of 15 years. Acta Neuropathol 102:195–199PubMed

54.

Tsuchiya K, Ikeda M, Hasegawa K, Fukui T, Kuroiwa T, Haga C, Oyanagi S, Nakano I, Matsushita M, Yagishita S, Ikeda K (2001) Distribution of cerebral cortical lesions in Pick’s disease with Pick bodies: a clinicopathological study of six autopsy cases showing unusual clinical presentations. Acta Neuropathol 102:553–571PubMed

55.

Tsuchiya K, Ikeda K, Mimura M, Takahashi M, Miyazaki H, Anno M, Shiotsu H, Akabane H, Niizato K, Uchihara T, Tominaga I, Nakano I (2002) Constant involvement of the Betz cells and pyramidal tract in amyotrophic lateral sclerosis with dementia: a clinicopathological study of eight autopsy cases. Acta Neuropathol 104:249–259PubMed

56.

Tsuchiya K, Murayama S, Mitani K, Oda T, Arima K, Mimura M, Nagura H, Haga C, Akiyama H, Yamanouchi H, Mizusawa H (2005) Constant and severe involvement of Betz cells in corticobasal degeneration is not consistent with pyramidal signs: a clinicopathological study of ten autopsy cases. Acta Neuropathol 109:353–366CrossRefPubMed

57.

Uchihara T, Ikeda K, Tsuchiya K (2003) Pick body disease and Pick syndrome. Neuropathology 23:318–326CrossRefPubMed

58.

Uchihara T, Tsuchiya K, Nakamura A, Akiyama H (2005) Silver staining profiles distinguish Pick bodies from neurofibrillary tangles of Alzheimer type: comparison between Gallyas and Compbell–Switzer methods. Acta Neuropathol 109:483–489CrossRefPubMed

59.

Vonsattel JPG, Binetti G, Hedley-Whyte ET, Growdon JH (2001) Pick disease. In: Duckett S and De La Torre JC (eds) Pathology of the aging human nervous system, 2nd edn. Oxford, Oxford, pp 190–206

60.

Yokota O, Ishizu H, Terada S, Tsuchiya K, Haraguchi T, Nose S, Kawai K, Ikeda K, Kuroda S (2002) Preservation of nigral neurons in Pick’s disease with Pick bodies: a clinicopathological and morphometric study of five autopsy cases. J Neurol Sci 194:41–48CrossRefPubMed

Title: Pathological Heterogeneity of the Precentral Gyrus in Pick’s Disease: A Study of 16 Autopsy Cases
Authors: Kuniaki Tsuchiya
Yue-Shan Piao
Tatsuro Oda
Akihide Mochizuki
Kunimasa Arima
Kazuko Hasegawa
Chie Haga
Akiyoshi Kakita
Koji Hori
Itaru Tominaga
Saburo Yagishita
Haruhiko Akiyama
Hitoshi Takahashi
Publication date: 01-07-2006
Publisher: Springer-Verlag
Published in: Acta Neuropathologica / Issue 1/2006
Print ISSN: 0001-6322
Electronic ISSN: 1432-0533
DOI: https://doi.org/10.1007/s00401-005-0028-6

At a glance: The STEP trials

Springer Medicine

Pathological Heterogeneity of the Precentral Gyrus in Pick’s Disease: A Study of 16 Autopsy Cases

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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