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01-02-2005 | Case Report

Ependymoma with neuropil-like islands: a case report with diagnostic and histogenetic implications

Authors: Marco Gessi, Carla Marani, Jennian Geddes, Antonella Arcella, Giovanna Cenacchi, Felice Giangaspero

Published in: Acta Neuropathologica | Issue 2/2005

Abstract

We describe a case of ependymoma with neuronal differentiation in form of neuropil-like islands. A 6-year-old boy presented at clinical examination for a short history of headaches and vomiting. Brain computed tomography showed a large, partially cystic, parieto-occipital lesion. The tumor was composed by glial fibrillary acidic protein-positive round cells with a perivascular arrangement and scattered neuropil-like islands, showing intense positivity for synaptophysin. Despite radiotherapy, the tumor recurred, showing frank features of anaplasia, but lacking the neuropil-like islands. The histological features of the tumor are discussed in the light of the concept that neuronal differentiation can occur occasionally in gliomas of different lineage without affecting the expected biological behavior.

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Title: Ependymoma with neuropil-like islands: a case report with diagnostic and histogenetic implications
Authors: Marco Gessi
Carla Marani
Jennian Geddes
Antonella Arcella
Giovanna Cenacchi
Felice Giangaspero
Publication date: 01-02-2005
Publisher: Springer-Verlag
Published in: Acta Neuropathologica / Issue 2/2005
Print ISSN: 0001-6322
Electronic ISSN: 1432-0533
DOI: https://doi.org/10.1007/s00401-004-0927-y

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Ependymoma with neuropil-like islands: a case report with diagnostic and histogenetic implications

Abstract

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Abstract

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