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01-10-2003 | Regular Paper

Age-associated prevalence and risk factors of Lewy body pathology in a general population: the Hisayama study

Authors: Yoshinobu Wakisaka, Akiko Furuta, Yumihiro Tanizaki, Yutaka Kiyohara, Mitsuo Iida, Toru Iwaki

Published in: Acta Neuropathologica | Issue 4/2003

Abstract

In dementia with Lewy bodies (DLB), the Lewy bodies (LBs) are an essential substrate. Although LB pathology has gained increasing attention as one of the major causes of dementia, little is known about the exact prevalence of LB pathology in the general population. In addition, the pathology of Alzheimer-type dementia (ATD) is frequently associated with DLB. To investigate the prevalence of LB pathology in a community-based population and to evaluate the relationship between LB and ATD pathology, we performed an analysis of 102 consecutive autopsy cases. The survey extended over 2.5 years and autopsy rate was 70.5%. LB pathology was detected using α-synuclein immunohistochemistry and was assessed based on consensus guidelines for DLB. ATD pathology was evaluated by both CERAD and NIA-RI criteria. Twenty-nine subjects were clinically demented. LB pathology was present in 23 (22.5%) of 102 cases, and in 12 (41.4%) of the demented subjects. The LB score was not significantly different between DLB cases and non-demented subjects with LB pathology (nd-LB), while the Braak stages were significantly different between the two groups. Prevalence of LB pathology constantly increased with age. DLB cases accompanying severe ATD pathology showed more rapid increase of LB scores than did DLB cases without severe ATD pathology. Moreover, DLB cases with severe ATD pathology had poorer prognoses than those without severe ATD pathology. Our results suggested that aging and severe ATD pathology have a strong effect on the evolution of LB pathology.

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Title: Age-associated prevalence and risk factors of Lewy body pathology in a general population: the Hisayama study
Authors: Yoshinobu Wakisaka
Akiko Furuta
Yumihiro Tanizaki
Yutaka Kiyohara
Mitsuo Iida
Toru Iwaki
Publication date: 01-10-2003
Publisher: Springer-Verlag
Published in: Acta Neuropathologica / Issue 4/2003
Print ISSN: 0001-6322
Electronic ISSN: 1432-0533
DOI: https://doi.org/10.1007/s00401-003-0750-x

At a glance: The STEP trials

Springer Medicine

Age-associated prevalence and risk factors of Lewy body pathology in a general population: the Hisayama study

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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